DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and Trpc6

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_006509912.1	Gene:	Trpc6 / 22068	MGIID:	109523	Length:	949	Species:	Mus musculus

Alignment Length:	856	Identity:	297/856 - (34%)
Similarity:	460/856 - (53%)	Gaps:	126/856 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG 102
            |.:||::||.|.|.|::|.||::|::.   ..:|:||:|.:|:.||.||:.||:||:.|||:...
Mouse   113 LSIEEERFLDAAEYGNIPVVRKMLEEC---HSLNVNCVDYMGQNALQLAVANEHLEITELLLKKE 174

  Fly   103 VETK--DALLHAINAEFVEAVELLLEHEELIYKEGEPYS------------WQKVDINTAMFAPD 153
            ..::  ||||.||:..:|..||.:|.|.  .:.||:..:            :...|.:...|:.|
Mouse   175 NLSRVGDALLLAISKGYVRIVEAILNHP--AFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHD 237

  Fly   154 ITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPS 218
            :||::||||...:||:..||.:||.:..|||..|.|.||.:....||..||.||:|.|:.|.||:
Mouse   238 VTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPA 302

  Fly   219 LICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYD 283
            .:.|:|.||::||.:||.||..||..|:|.|::|..|..||:.|.|.|||..|.:.|:..|||.|
Mouse   303 YLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGD 367

  Fly   284 PQMSSYEPGD--RMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQ 346
            .:  :.:|||  |.:|:||..||.|:.||||||.|.||.|.||||:.|.|.|::::..|.:.:..
Mouse   368 AE--TRQPGDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLA 430

  Fly   347 VAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRM 411
            ||:..|...|||.|||..:.|:::|.|||||:.||:|:..||.:|::  ..||    |..||..:
Mouse   431 VAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVM--NAAD----RFEGTKLL 489

  Fly   412 KKELAEQELRQ--RGQTP--SKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSL 472
            ..|.:....||  |.:|.  |.:|::::.:|||.:|.|.:||:..|.|.||..:||.:||...::
Mouse   490 PNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAI 554

  Fly   473 YVSVMCLRAFAY---------------IQQATEIARDPQMAY--IPREKWHDFDPQLIAEGLFAA 520
            :.:....|..|:               ::..|::.....:.|  :.|.||...|||:|:|||:|.
Mouse   555 FAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAI 619

  Fly   521 ANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSK 585
            |.|.|..::.::...|...|||||||||.|.||.||..|:.:|..||..|:..|..|:...::::
Mouse   620 AVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNE 684

  Fly   586 CYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFG 650
            .                      |..:.||.::||||.||:..:....::....:....|.:::|
Mouse   685 A----------------------FTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYG 727

  Fly   651 SYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVI 715
            .|:|..||||||:||||:::|:..|::.:|.||||||.|||.||||:..|||.|||::||.|.::
Mouse   728 VYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLL 792

  Fly   716 RIFRKSSK----TIDRQRS--------KKRKEQEQFS---------------------------- 740
            .:..|..|    .|..|:.        .||.|:::|.
Mouse   793 YLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKKFGISGSHEDLSKFSLDKNQLAHNKQSSTRS 857

  Fly   741 --------------EYDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLEIFEN 791
                          :|..||:.|:.|||.......|::.|:|.::.|:|.:|:::|||:||....
Mouse   858 SEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQ 922

  Fly   792 SGMDVSSANKK 802
            :..|::...:|
Mouse   923 NTEDLAELIRK 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	286/826 (35%)
		ANK	48..195	CDD:238125	58/160 (36%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	15/54 (28%)
		TRP_2	187..246	CDD:285535	27/58 (47%)
		DUF2031	<706..>805	CDD:299055	32/151 (21%)
Trpc6	XP_006509912.1	trp	100..915	CDD:273311	291/836 (35%)
		ANK repeat	150..177	CDD:293786	12/26 (46%)
		ANK repeat	179..203	CDD:293786	11/25 (44%)
		ANK repeat	230..265	CDD:293786	14/34 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770