DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and Trpc3

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_062383.2	Gene:	Trpc3 / 22065	MGIID:	109526	Length:	910	Species:	Mus musculus

Alignment Length:	854	Identity:	297/854 - (34%)
Similarity:	465/854 - (54%)	Gaps:	119/854 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KSVGGCCVPLGLPQP-LLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLA 86
            ::|.|.....|...| |..||::||.|.|.|::|.||::|:::   :.:|:||:|.:|:.||.||
Mouse    82 QAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEES---RTLNVNCVDYMGQNALQLA 143

  Fly    87 IDNENLEMVELLVVMG--VETKDALLHAINAEFVEAVELLLEH---------------EELIYKE 134
            :.||:||:.|||:...  ....||||.||:..:|..||.:|.|               :||  ::
Mouse   144 VGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQEL--RD 206

  Fly   135 GEPYSWQKVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAED 199
            .:.|::   |.:...|:|||||::||||.:.:|::.:||.:||.:..|||..|.|.:|......|
Mouse   207 DDFYAY---DEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCSDCAEKQRLD 268

  Fly   200 SLRHSLSRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAV 264
            :..||.||:|.|:.|.||:.:.|:|.||::||.:||.||..||..|:|.|::|..|..||:.|.|
Mouse   269 AFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVV 333

  Fly   265 DLLDQTRTSNELAIILNYDPQMSSYEP----GDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIW 325
            .:||..|.|.|:..|||.|  :.|.||    |.:.||:|:..||.|:.||||||.|.||.|.:||
Mouse   334 GVLDLCRDSEEVEAILNGD--LESAEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIW 396

  Fly   326 YDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFI 390
            |:.|.|.|.::|..|.:.:..||:..|...:.|..||..|.|:::|.|||||:.||:|::.||.:
Mouse   397 YENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGL 461

  Fly   391 LILVSQRADDDFVRIFGTTRMKK----ELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFA 451
            |:.   .|.|   |..|.|.:..    :..:|..|.:....:..|::::::|:|.:|.|.:|::.
Mouse   462 LVF---NASD---RFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWL 520

  Fly   452 VGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQ---------------QATEIARDPQMAYI- 500
            .|.:.|:..:||.:||...|::::....|..|::|               ..:|:...|::.|.
Mouse   521 EGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFT 585

  Fly   501 -PREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVL 564
             .|:||...|||:|:|||:|.|.|.|..::.::...|...|||||||||.|.||.||..::.:|.
Mouse   586 YARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVF 650

  Fly   565 FAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGL 629
            .||..|:..|..|:...:     |.|.                 |..:.||.::|||:.||:..:
Mouse   651 LAFMIGMFILYSYYLGAK-----VNPA-----------------FTTVEESFKTLFWSIFGLSEV 693

  Fly   630 DDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSY 694
            ....|.....:....|.:::|.|:|..|:||||:||||:::||..|::.||.||||||:|||:||
Mouse   694 TSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY 758

  Fly   695 FEDSATLPPPFNVLPSVK----WVIRIFR--------------------KSSKTIDRQRSKKRKE 735
            |:|..||||||:::||.|    :::||..                    ||...:..|.:.:..|
Mouse   759 FDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFE 823

  Fly   736 QEQF-------SEYDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLEIFENSG 793
            ...|       :.|..||:.|:.|||.......||:.|:|.::.|:|.:|:::|||:||
Mouse   824 SHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLE------ 882

  Fly   794 MDVSSANKK 802
             |.|.|.::
Mouse   883 -DKSQATEE 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	281/808 (35%)
		ANK	48..195	CDD:238125	59/163 (36%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	15/42 (36%)
		TRP_2	187..246	CDD:285535	25/58 (43%)
		DUF2031	<706..>805	CDD:299055	32/128 (25%)
Trpc3	NP_062383.2	trp	85..879	CDD:273311	289/831 (35%)
		ANK	108..242	CDD:238125	49/141 (35%)
		ANK repeat	135..166	CDD:293786	12/30 (40%)
		ANK repeat	215..250	CDD:293786	15/34 (44%)
		TRP_2	256..315	CDD:285535	25/58 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770