DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and Trpc2

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001103367.1	Gene:	Trpc2 / 22064	MGIID:	109527	Length:	890	Species:	Mus musculus

Alignment Length:	842	Identity:	271/842 - (32%)
Similarity:	429/842 - (50%)	Gaps:	140/842 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PLGLPQP----LLLEEKKF----LLAVERGDMPNVRRILQKA-----------LRHQHININCMD 76
            ||. |||    ::.::.||    |.|::.|.:..|:::|:.:           ||:..   ...|
Mouse     3 PLS-PQPNWTEIVNKKLKFPPTLLRAIQEGQLGLVQQLLESSSDASGAGPGGPLRNVE---ESED 63

  Fly    77 PLGRRALTLAIDNENLEMVELLVVMGV-----ETKDALLHAINAEFVEAVELLLEHEELIYKEGE 136
            ...|.||.||| ....|::..:::..|     :..:|||.|::......|..||...|  .::|
Mouse    64 RSWREALNLAI-RLGHEVITDVLLANVKFDFRQIHEALLVAVDTNQPAVVRRLLARLE--REKG- 124

  Fly   137 PYSWQKVD------------INTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGC 189
                :|||            |:.:.|||.:|||.||..|:.:||.::|:|:|..:..||.:.|.|
Mouse   125 ----RKVDTKSFSLAFFDSSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTIARPHPVSCAC 185

  Fly   190 EECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMD 254
            .||......|.|:.||||:|.||.:.|.:.:.|.|.|.::.|||||.|||.||..|.|.|.:|:.
Mouse   186 LECSNARRYDLLKFSLSRINTYRGIASRAHLSLASEDAMLAAFQLSRELRRLARKEPEFKPQYIA 250

  Fly   255 LRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSSYEP-----GDRM-----SLTRLVQAISYKQK 309
            |...||.:..:||...|..:|:..:||...:.|..||     |...     :|.||..|::|.||
Mouse   251 LESLCQDYGFELLGMCRNQSEVTAVLNDLGEDSETEPEAEGLGQAFEEGIPNLARLRLAVNYNQK 315

  Fly   310 KFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPF 374
            :||||...||:|||||...|.|:|..:.:.|:.....:.:..|..|:.|..||..:.|:|::.|.
Mouse   316 QFVAHPICQQVLSSIWCGNLAGWRGSTTIWKLFVAFLIFLTMPFLCIGYWLAPKSQLGRLLKIPV 380

  Fly   375 MKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVVMYVI 439
            :|||:|::|||:||..|:      .:..|       |:.:|:..:.|.:....:.|.:|   :|.
Mouse   381 LKFLLHSASYLWFLIFLL------GESLV-------METQLSTFKGRSQSVWETSLHMI---WVT 429

  Fly   440 GFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLR------AFAYIQQATEIARDPQMA 498
            ||:|.|.:|::..|::|||.:.|||:|.:..|||::...||      |:.:.:.|::........
Mouse   430 GFLWFECKEVWIEGLRSYLLDWWNFLDVVILSLYLASFALRLLLAGLAYMHCRDASDSTTCRYFT 494

  Fly   499 YIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLV 563
            ...|.:|...|||.:||.|||..::.|..:|.::...:..||.||||:|:|:.|:::|.||..::
Mouse   495 TAERSEWRTEDPQFLAEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMIRFMFILMII 559

  Fly   564 LFAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGM-- 626
            |.||.||||.:            || |..|::            :.||..|:.|.|||..|||
Mouse   560 LTAFLCGLNNI------------YV-PYQESE------------KLGNFNETFQFLFWTMFGMEE 599

  Fly   627 ---VGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFART 688
               |.:..|.:      ..|.|..|:|.::::.||||||:||||::||:..|::.:|.||||||:
Mouse   600 HTVVDMPQFLV------PEFVGRAMYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKFARS 658

  Fly   689 KLWMSYFEDSATLPPPFNVLPSVK----WVIRIFR---------KSSK---------TIDRQRSK 731
            ||::|||.:..|||.|||:|||.|    .|.||||         |:.|         |....|:.
Mouse   659 KLYLSYFREGLTLPVPFNILPSPKAAFYLVRRIFRFLCCGSSCCKAKKSDYPPIGTFTNPGARAG 723

  Fly   732 KRKEQEQFSEYDNIMRSLVWRYVAAMHRKFENNPVSE--DDINEVKSEINTMRYEMLEIFEN 791
            ...|.|:.|....::::||.||:....|:||.....:  :.:.|:...::.::.|:..:.:|
Mouse   724 SAGEGERVSYRLRVIKALVQRYIETARREFEETRRKDLGNRLTELTKTVSRLQSEVASVQKN 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	261/808 (32%)
		ANK	48..195	CDD:238125	48/174 (28%)
		ANK repeat	78..114	CDD:293786	12/40 (30%)
		ANK repeat	134..177	CDD:293786	18/54 (33%)
		TRP_2	187..246	CDD:285535	27/58 (47%)
		DUF2031	<706..>805	CDD:299055	27/110 (25%)
Trpc2	NP_001103367.1	trp	23..761	CDD:273311	261/795 (33%)
		ANK	63..>172	CDD:238125	35/116 (30%)
		ANK repeat	93..138	CDD:293786	12/51 (24%)
		ANK repeat	140..173	CDD:293786	14/32 (44%)
		TRP_2	183..242	CDD:285535	27/58 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810