DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trp-2

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001022703.1	Gene:	trp-2 / 192056	WormBaseID:	WBGene00006615	Length:	886	Species:	Caenorhabditis elegans

Alignment Length:	866	Identity:	357/866 - (41%)
Similarity:	530/866 - (61%)	Gaps:	72/866 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMGVE 104
            |.||:|||:.||||:.:||::| ..:..:..||||:|||||.||.:||:|||:||:|||:...:|
Worm    32 LREKQFLLSCERGDIGSVRKLL-AGISTETFNINCLDPLGRNALLIAIENENIEMIELLLDHNIE 95

  Fly   105 TKDALLHAINAEFVEAVELLLEHEELIYK-EGEPYSWQKVDINT-AMFAPDITPLMLAAHKNNFE 167
            |.||:|:||..|.|||||:::||.|.:.| :.|.   |.|:|.. :.|.|||||::|||||:|:|
Worm    96 TGDAILYAIGEENVEAVEIIVEHLEKMDKFDSER---QGVEITEHSAFTPDITPIVLAAHKDNYE 157

  Fly   168 ILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITAF 232
            .:::.||:...||.|||:||.|.||.....|||||.|.||:|.||||.|||||||::.|||:.||
Worm   158 CIKLFLDKKGTVPHPHDVRCSCPECYVAREEDSLRLSRSRINAYRALTSPSLICLSARDPILYAF 222

  Fly   233 QLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILN------YDPQMSSYEP 291
            :|||||:.|:..|.|.:::|.:|.::||||.|.:|||.|.|.||.::||      :|...::|
Worm   223 ELSWELKRLSFIENEFRTDYEELSQKCQKFCVHMLDQVRGSKELEVVLNHTTNAWHDVTSANY-- 285

  Fly   292 GDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCL 356
            |:...|.||..||...||:||||.|.||||..|||:|:...|..:.:.|:|......:.|||:.|
Worm   286 GNPEKLARLKLAIQLSQKRFVAHPNCQQLLLDIWYEGVESVRCTNFIYKLIFYILGMLSFPLFSL 350

  Fly   357 IYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRAD--DDFVRIFGTTRMKKELAEQE 419
            :|:.||:...||..:|||:|||.|:.||:|||.:||:.|||.:  |:.:|.....|  ||
Worm   351 VYLLAPHSSMGQFAKKPFIKFLSHSGSYIFFLILLIMASQRMNVIDNILRTDDVDR--KE----- 408

  Fly   420 LRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAY 484
              .||..|:.:|..:.::|:|.:|.|:::::..|:.:|.||:||.:||:.||||:....||..||
Worm   409 --TRGPPPTIIECAIFLWVLGLIWVEIKQLWECGLYNYCRNLWNILDFITNSLYLCTTALRVVAY 471

  Fly   485 IQQATEIARDPQM---AYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISL 546
            :|...|..|...:   .::||..|..:||.|::|..||.||:||:|||||:|:::||||||:|||
Worm   472 VQVEQEALRANSVHIARHLPRRDWDAWDPTLLSECFFATANIFSSLKLVHIFTVSPHLGPLKISL 536

  Fly   547 GRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEAD------WGSHGDSC-M 604
            |||||||||||.:|.||||||||||||||||:|::.:::|.:....:.:      :....:|| .
Worm   537 GRMVIDIVKFFMVYALVLFAFACGLNQLLWYYASMRQNECNLYEQYKNEKSLSYKYEHLKESCDD 601

  Fly   605 KWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMS 669
            |::...:::.::::||||.||:|.|..|.|......:.:.|..:||||...::|||||:||||||
Worm   602 KYKSCSSIYHTAETLFWALFGLVDLTHFRLKEDHFLSEWTGKTIFGSYCCCSIIVLLNMLIAMMS 666

  Fly   670 NSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVI----RIFRKSSKTIDRQRS 730
            |||..|.:.:|.||||||::|::.||:|:||||||||::||.|.:.    .:.:|.......|:.
Worm   667 NSYQYISDQADIEWKFARSRLFLEYFDDTATLPPPFNIVPSPKSIYYCLHYLTKKLCNCTKLQQP 731

  Fly   731 KKRKEQEQFSEYDNIMRSLVWRYVAAMHRKFENNPVSEDDINEVKSEINTMRYEMLEIFENSGMD 795
            .|:|                     :|..:.:|..:.:....::.......||        ||..
Worm   732 SKQK---------------------SMRVESKNLAIRQRPRKQLPENCAKNRY--------SGAQ 767

  Fly   796 VSSANKKERQPRPRRIKVWERRLMKGFQVAPV-QNGCELDAFGNVNGQGEMQEIKVESIPSKPAK 859
            ..|.|||:.....||:|. ...|:|.|.|..: :.|....:..::...|.::...:.| .||.:.
Worm   768 FHSRNKKKTAMAERRLKN-SALLLKEFPVPQMFKAGQRNMSISSIQSNGRLKPSFMPS-SSKLSW 830

  Fly   860 ETAKERFQRVARTVLLQSTTH 880
            ...|.:..|::::..: .|||
Worm   831 SNLKVKASRLSKSKSI-DTTH 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	327/759 (43%)
		ANK	48..195	CDD:238125	74/148 (50%)
		ANK repeat	78..114	CDD:293786	21/35 (60%)
		ANK repeat	134..177	CDD:293786	19/43 (44%)
		TRP_2	187..246	CDD:285535	35/58 (60%)
		DUF2031	<706..>805	CDD:299055	18/102 (18%)
trp-2	NP_001022703.1	trp	34..757	CDD:273311	331/758 (44%)
		ANK	37..163	CDD:238125	65/129 (50%)
		ANK repeat	69..96	CDD:293786	15/26 (58%)
		TRP_2	177..236	CDD:285535	35/58 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159952
Domainoid	1	1.000	280	1.000	Domainoid score	I888
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	722	1.000	Inparanoid score	I326
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		otm14461
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.800