DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and spe-41

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001254872.1	Gene:	spe-41 / 175446	WormBaseID:	WBGene00004976	Length:	854	Species:	Caenorhabditis elegans

Alignment Length:	713	Identity:	165/713 - (23%)
Similarity:	311/713 - (43%)	Gaps:	99/713 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DNENLEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKVDINTAMFAP 152
            |:..|..::.| :|...::::|..|:..........|:|...:::.:. ||..:....|:..|.|
Worm    80 DDGRLSSLQSL-LMDTSSEESLKEALLLSIAVGSRPLVEFVLVLFVDA-PYLERSGSANSPHFPP 142

  Fly   153 DITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSR-VNIYRALCS 216
            .:||||||...|||.|::.|:.||..:.:||.|.|.|:.|.|   |....||.:| |::.|||.|
Worm   143 HMTPLMLACILNNFSIVQCLITRGHCIQIPHFITCECKTCKR---ETVTTHSSTRLVDVMRALSS 204

  Fly   217 PSLICLTSNDPIITAFQLSWELRNLALTEQ-ECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIIL 280
            .:.:.|.::|.......::.:|:.||..:| |....|.||....|:|...:.||....:|..:::
Worm   205 EAYLWLATDDVFAATCAVARDLQQLASDDQLEYVETYRDLEMNVQRFLCRISDQAWRVDEFNMMV 269

  Fly   281 ---NYDPQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSI----WYDGLPGFRRKSIV 338
               ||.|:..:     .:|..||..|:..:.::|...:|.|..:.|:    ||:  .|.:.|...
Worm   270 ANRNYCPERMT-----EISSPRLQMAMDSQMRQFTCSTNSQTTIKSVFRSDWYN--YGIKPKRDA 327

  Fly   339 DKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQR------ 397
            .:.:   :..:|.|...:::...|.  .|..|..|..:|:.|.:.||.||...||   |
Worm   328 WRFL---RACILMPFLVMLHAFMPT--KGTTMCVPLARFIAHITMYLVFLIAAIL---RPTIGFY 384

  Fly   398 -ADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNM 461
             |..|.:.:                    |...||:.:..||:|...|:....:.||...:....
Worm   385 FAWTDSIEV--------------------TVQALEIFMYAYVMGLALEKGILFYRVGRDGFFAFW 429

  Fly   462 WNFIDFLRNSLYVSVMCLRAFAYI----QQATEIARDPQMAYIPREKWHDFDPQLIAEGLFAAAN 522
            |.:.|       .:::.:..|:.|    :.....|.||  :.:.|..|..|:..|:.|...|.|.
Worm   430 WRWFD-------AALIFIFLFSLIFFTGKWGKREAFDP--SSVDRMHWPSFEFSLLHEICLAIAC 485

  Fly   523 VFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCY 587
            |.|.||..:...:...:|...||:|:.|.....:..|...::.:|:.|||.::..:  |.:|...
Worm   486 VLSILKCFYYAQMMKSIGGSVISVGKCVGKTYTYILIMVAIIVSFSVGLNIIVDPY--LNRSTMK 548

  Fly   588 VLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDF---------ELSGIK---SY 640
            :   |:.|:....||      :..:..||::|||:.||.:|...|         .:..:|   :.
Worm   549 I---GDQDYTKTTDS------YETIGTSSKNLFWSIFGYLGPSTFTTVVGNTGPNMDPVKHTLNS 604

  Fly   641 TRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPF 705
            :.|  .::...|..|.:|.:|||:.:::......:.::.:.|:||.|..::..:.......|||.
Worm   605 STF--EILAAVYHGILIITVLNLMTSILVKGADEVLDNEEMEFKFTRAAIYSEFLSWEMAAPPPL 667

  Fly   706 NVLPSV-----KWVIRIFRKSSKTIDRQRSKKRKEQEQFSEYDNIMRSLVWRYVAAMHRKFEN 763
            |::..|     :.:::.:..|....::..:...::|....:|..::..:..|:||:...|:::
Worm   668 NLILVVAHFVHRNLLKRYYASPAWGEKPANDDVEDQAADEQYMQLLMVVFARFVASKECKYKS 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	165/713 (23%)
		ANK	48..195	CDD:238125	32/106 (30%)
		ANK repeat	78..114	CDD:293786	6/25 (24%)
		ANK repeat	134..177	CDD:293786	17/42 (40%)
		TRP_2	187..246	CDD:285535	18/59 (31%)
		DUF2031	<706..>805	CDD:299055	9/63 (14%)
spe-41	NP_001254872.1	trp	87..671	CDD:273311	155/645 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910