DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trpl and LOC103910003

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_009296662.2	Gene:	LOC103910003 / 103910003	-ID:	-	Length:	482	Species:	Danio rerio

Alignment Length:	496	Identity:	228/496 - (45%)
Similarity:	321/496 - (64%)	Gaps:	32/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKVDINTAMFAPDITPLML 159
            :|||:..||.|.||||:||..|.|.||||||.:.:...::..|.  ..:|...:.|.|||||:||
Zfish     1 MELLLSHGVHTGDALLYAIRKEVVGAVELLLSYRKPCGEKQVPS--LMMDTQFSEFTPDITPIML 63

  Fly   160 AAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTS 224
            |||.||:||:::|:.|...:|.||.|||.|.|||..:..||||||.||:|||:||.|||||.|:|
Zfish    64 AAHTNNYEIIKLLVQRKVTIPRPHQIRCDCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSS 128

  Fly   225 NDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNY-DPQMSS 288
            .|||:|||:|.|||:.|:..|.|.:.||.:|.:||:.||.|||||.|:|.||..|||: |.....
Zfish   129 EDPILTAFRLGWELKELSKVENEFRQEYDELSQQCKLFAKDLLDQARSSRELETILNHRDDHSEE 193

  Fly   289 YEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPL 353
            .:.|:...|.:|..||.|.||:|||..|.||||:::||||.||:||:....|::....:.:|||:
Zfish   194 LDLGECRDLAKLKLAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRRHWAVKLVTCFIIGLLFPV 258

  Fly   354 YCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQ 418
            :.:||:.||....|..::|||:||:.|.:|||.|||:|:|.||                 .:.:.
Zfish   259 FSIIYLLAPKSTLGTFIKKPFIKFICHTASYLTFLFLLLLASQ-----------------HIVQT 306

  Fly   419 ELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFA 483
            :|..:|..|:.:|.:::.:|:||:|.|::|::..|...|:.:.||.:||..||||::.:.|:..|
Zfish   307 DLHVQGPPPTFVEWMILPWVLGFIWAEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKMVA 371

  Fly   484 YIQQATEIARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGR 548
            |.:..:.         .||.:|..:.|.||||.|||.||:||:|:|:.||:.|.|||||||||||
Zfish   372 YFKYNSS---------RPRVEWEMWHPTLIAEALFAIANIFSSLRLISLFTANSHLGPLQISLGR 427

  Fly   549 MVIDIVKFFFIYTLVLFAFACGLNQLLWYF---AALEKSKC 586
            |::||:||.|||.|||.|||.|||||.:|:   |:.|.:.|
Zfish   428 MLLDILKFLFIYCLVLLAFANGLNQLYFYYETKASEEPNNC 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	228/496 (46%)
		ANK	48..195	CDD:238125	49/99 (49%)
		ANK repeat	78..114	CDD:293786	11/18 (61%)
		ANK repeat	134..177	CDD:293786	19/42 (45%)
		TRP_2	187..246	CDD:285535	36/58 (62%)
		DUF2031	<706..>805	CDD:299055
LOC103910003	XP_009296662.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010