DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trpc4a

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001276811.1	Gene:	trpc4a / 102725537	ZFINID:	ZDB-GENE-131217-1	Length:	934	Species:	Danio rerio

Alignment Length:	900	Identity:	369/900 - (41%)
Similarity:	527/900 - (58%)	Gaps:	110/900 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VPLGLPQ------PLLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAID 88
            :||.:.:      ||   ||.:|.|||:||..:|::.|.:|..:..|||||:|||||.||.:||:
Zfish    18 IPLRIVRSESELSPL---EKAYLWAVEKGDYGSVKQALIEAEIYFKININCIDPLGRTALLIAIE 79

  Fly    89 NENLEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKV-----DINTA 148
            |||||::|||:...|...|||||||..|.|.||||||.|:       :|....:|     |...:
Zfish    80 NENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHK-------KPSGGMQVPPILLDKQFS 137

  Fly   149 MFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRA 213
            .|.|||||::||||.||:||:::|:.:|.::|.||.:||.|.|||..:..||||||.||:|||||
Zfish   138 DFTPDITPIILAAHTNNYEIIKMLVQKGVSMPQPHQVRCNCMECVSSSDVDSLRHSRSRLNIYRA 202

  Fly   214 LCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAI 278
            |.||||:.|:|.||.:|||||||||:.|:..|.|.||||.:|.:||::||.|||||||:|.||.:
Zfish   203 LASPSLVALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSQQCKQFAKDLLDQTRSSRELEL 267

  Fly   279 ILNYDPQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVIC 343
            ||||...::..|......|.||..||.|.||:|||..|.||||:|.|||..||:||:....|.:.
Zfish   268 ILNYKDDINLLEDEGINDLARLKLAIKYHQKEFVAQPNCQQLLASRWYDEFPGWRRRHWASKFMT 332

  Fly   344 IAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGT 408
            ...:.:|||.:.|.|:.||....|..:||||:||:.|.:|||.|||:|:|.||..:.:.:.....
Zfish   333 CIFIGLLFPFFSLFYLIAPKSHYGLFIRKPFIKFICHTASYLTFLFLLLLASQHVNRNLLDQDEN 397

  Fly   409 TRMKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLY 473
            :..|.|...|.|     .|:.:|.:::.:|:||||.|:::::..|.:.|:.:.||.:||:.||||
Zfish   398 SDCKNENLRQNL-----APTTVEWMILPWVLGFVWAEIKQMWDGGFQDYIHDWWNLMDFVMNSLY 457

  Fly   474 VSVMCLRAFA---YIQQATEIARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSI 535
            ::.:.|:..|   |..|.             |::|..:.|.|:.|.|||.||:||:|:|:.||:.
Zfish   458 LATISLKIVALSKYNNQC-------------RDEWDMWHPALVGEALFAIANIFSSLRLISLFTA 509

  Fly   536 NPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHG 600
            |.||||||||||||::||:||.|||.|||.|||.|||||.:|:.:..|:             |:.
Zfish   510 NSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYESDGKT-------------SNN 561

  Fly   601 DSCMKWR------RFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIV 659
            .:|...|      .|..:||:.|||||:.||:|.|....:.....:|.|.|..|||:||:|:::|
Zfish   562 VTCKGIRCSEQNNAFTTMFETLQSLFWSIFGLVALHVTNVDAKHDFTEFVGATMFGTYSIISLVV 626

  Fly   660 LLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPS-------VKWV-IR 716
            |||:|||||:|||..|.:|:|.|||||||||||||||:..||||||||:||       ::|: ..
Zfish   627 LLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNVVPSPKSAWYLIRWIKTH 691

  Fly   717 IF----RKSSKTIDRQRSKKRKEQEQFSEYDNIMRSLVWRYVAAMHRKFENNP-VSEDDINEVKS 776
            .|    ||.::|:.....:..:..... :|..::|:||.|||||..|..:... ::||:..|:|.
Zfish   692 CFKIKQRKRTETLGSLGIRAAENVRTNXQYQEVLRNLVKRYVAARIRDAKKEEGLTEDNFKELKQ 756

  Fly   777 EINTMRYEMLEIFE--NSGMDVSSANKKER--------------------QPRPRRIKVWERRLM 819
            :|::.|||::.:.:  .:||..|..|..:.                    :.:.|...:....:.
Zfish   757 DISSFRYEVMGMMKGTKTGMSTSKGNTADSSLVYPENALKCNSTSTGSTLKGKMRLQSITNTMIQ 821

  Fly   820 KGFQVAPVQNGCELDAFGNV--------------NGQGEMQEIKVESIPSKPAKE 860
            :|...|....||...|..:|              |..|||..:..|:..|:..::
Zfish   822 EGGPKAWKPTGCSNLADSSVPNKTISHQLNCKGPNNPGEMYSVSEEAGESESEEQ 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	343/762 (45%)
		ANK	48..195	CDD:238125	75/151 (50%)
		ANK repeat	78..114	CDD:293786	22/35 (63%)
		ANK repeat	134..177	CDD:293786	18/47 (38%)
		TRP_2	187..246	CDD:285535	37/58 (64%)
		DUF2031	<706..>805	CDD:299055	31/133 (23%)
trpc4a	NP_001276811.1	trp	17..764	CDD:273311	350/786 (45%)
		ANK	35..162	CDD:238125	65/133 (49%)
		ANK repeat	70..98	CDD:293786	15/27 (56%)
		ANK repeat	99..133	CDD:293786	17/40 (43%)
		ANK repeat	135..166	CDD:293786	15/30 (50%)
		TRP_2	176..235	CDD:285535	37/58 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581920
Domainoid	1	1.000	270	1.000	Domainoid score	I1782
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm6331
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.700