Protein Alignment trpl and trpc6b

DIOPT Version :10

• Sequence 1: NP_476895.1
• Gene: trpl / 36003
• FlyBaseID: FBgn0005614
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_002665445.3
• Gene: trpc6b / 102725535
• ZFINID: ZDB-GENE-081030-19
• Length: 858
• Species: Danio rerio
• Alignment Length: 840
• Identity: 289/840 - (34%)
• Similarity: 453/840 - (53%)
• Gaps: 105/840 - (12%)

  Fly    42 EKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG--VE 104
            |::||.|.|.|::|.:||:|::.   ..:|:||:|.:|:.||.||:.||:||:.|||:...  ..
Zfish    67 EERFLEAAEYGNIPVIRRMLEEL---PELNVNCVDYMGQNALQLAVANEHLEVTELLLKKENLAR 128

  Fly   105 TKDALLHAINAEFVEAVELLLEHEEL----------IYKEGEPYSWQKVDINTAMFAPDITPLML 159
            ..||||.||:..::..||.:|.|:..          :..|.:. .:...|.:...|:.||||::|
Zfish   129 IGDALLLAISKGYIRIVEAILSHQAFADTTKLTSSPLQAETQD-DFFAYDEDGTRFSHDITPIIL 192

  Fly   160 AAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTS 224
            |:|.:.:||:.|||.:||.:..|||..|.|..|:.....||..||.||:|.|:.|.||:.:.|:|
Zfish   193 ASHCHEYEIVHILLRKGARIARPHDYFCKCNGCLYHQRHDSFSHSRSRINAYKGLASPAYLSLSS 257

  Fly   225 NDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSS- 288
            .||::||.:||.||..||..|:|.|::|..|..||:.|.|.|||..|.:.|:..|||.|.::..
Zfish   258 EDPVLTALELSNELAVLANIEKEFKNDYKTLSMQCKDFVVGLLDLCRNTEEVEAILNGDTEVGGH 322

  Fly   289 YEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPL 353
            ::.|||.:|.||..||.|:.||||||.|.||.|.||||:.|.|.|:::...|::.:..|.|..|:
Zfish   323 FDKGDRPNLVRLKLAIKYELKKFVAHPNCQQQLLSIWYENLSGLRQQTTAVKLLVVLGVVVGLPI 387

  Fly   354 YCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAE- 417
            ..|:|..||:.:.|:::|.||:||:.||:|:..||.:||:  ..||    |..||:.:......
Zfish   388 LALLYWIAPSSKLGKIIRGPFLKFVAHAASFTIFLGLLIM--NAAD----RFEGTSLLPNMTVHD 446

  Fly   418 --QELRQRGQTP-SKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCL 479
              .:|.:...|| :.:|::::.:|:|.:|.|.:||:::|.:.||...||.:||...:::|:....
Zfish   447 HPSQLFRMKTTPFTWMEMLIISWVVGMIWAECKEIWSLGPREYLLEPWNLLDFGMLAIFVTSFIA 511

  Fly   480 RAFAYIQ-------------QATEIARDPQMAY--IPREKWHDFDPQLIAEGLFAAANVFSALKL 529
            |..|:..             ..:.|....::.|  :.|..|...|||||:|||:|.|.|.|..::
Zfish   512 RFMAFYHANVAQNYVDKRYTDLSNITLPLEIEYYRLARVHWVPSDPQLISEGLYAIAVVLSFSRI 576

  Fly   530 VHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEA 594
            .::...|...|||||||||.|.||.||..|:.:|..||..|:..|..|:...:::..
Zfish   577 AYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKQNGA-------- 633

  Fly   595 DWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIV 659
                          |..:.||.::||||.||:..:....::....:....|.:::|.|:|..|||
Zfish   634 --------------FTTVEESFKTLFWAIFGLSEVKSVVINNGHKFIENIGYVLYGVYNVTMVIV 684

  Fly   660 LLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVIRIFRKSSKT 724
            |||:||||::||:..|::.:|.||||||.|||.||||:..|||.|||::||.|.||.:..:..:.
Zfish   685 LLNMLIAMINNSFQEIEDDADVEWKFARAKLWFSYFEEGGTLPVPFNLIPSPKSVISLAMRLKRL 749

  Fly   725 I--------------------DRQRSKKRKEQEQFSEYDNIMRSLVWRYVAAMHRKFENNPVSED 769
            :                    .:|:....|.....|.|..||:.|:.|||.......|.:.|:|.
Zfish   750 LLIPLHRHKEDLKEDTELNESGKQKESSEKNSPHTSRYQRIMKRLIKRYVIKAQTDKEGDEVNEG 814

  Fly   770 DINEVKSEINTMRYEMLEIFENSGMDVSSANKKERQPRP-----RRIKVWERRLMKGFQV 824
            ::.|:|.:|:::|:|:||             :|.||...     ||:   |.||:..:::
Zfish   815 ELKEIKQDISSLRFELLE-------------EKSRQTEELAELVRRL---EERLISQYKI 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	TRPV	48..784	CDD:454755	275/787 (35%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	15/42 (36%)
		TRP_CaM_bind1	798..883	CDD:467881	8/32 (25%)
		PHA03247	<961..1069	CDD:223021
trpc6b	XP_002665445.3	None