DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trpc6b

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_002665445.2	Gene:	trpc6b / 102725535	ZFINID:	ZDB-GENE-081030-19	Length:	858	Species:	Danio rerio

Alignment Length:	840	Identity:	288/840 - (34%)
Similarity:	451/840 - (53%)	Gaps:	105/840 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG--VE 104
            |::||.|.|.|::|.:||:|::.   ..:|:||:|.:|:.||.||:.||:||:.|||:...  ..
Zfish    67 EERFLEAAEYGNIPVIRRMLEEL---PELNVNCVDYMGQNALQLAVANEHLEVTELLLKKENLAR 128

  Fly   105 TKDALLHAINAEFVEAVELLLEHEEL----------IYKEGEPYSWQKVDINTAMFAPDITPLML 159
            ..||||.||:..::..||.:|.|:..          :..|.:. .:...|.:...|:.||||::|
Zfish   129 IGDALLLAISKGYIRIVEAILSHQAFADTTKLTSSPLQAETQD-DFFAYDEDGTRFSHDITPIIL 192

  Fly   160 AAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTS 224
            |:|.:.:||:.|||.:||.:..|||..|.|..|:.....||..||.||:|.|:.|.||:.:.|:|
Zfish   193 ASHCHEYEIVHILLRKGACIARPHDYFCKCNGCLYHQRHDSFSHSRSRINAYKGLASPAYLSLSS 257

  Fly   225 NDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSS- 288
            .||::||.:||.||..||..|:|.|::|..|..||:.|.|.|||..|.:.|:..|||.|.:...
Zfish   258 EDPVLTALELSNELAVLANIEKEFKNDYKTLSMQCKDFVVGLLDLCRNTEEVEAILNGDTEAGGH 322

  Fly   289 YEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPL 353
            ::.|||.:|.||..||.|:.||||||.|.||.|.||||:.|.|.|:::...|::.:..|.|..|:
Zfish   323 FDKGDRPNLVRLKLAIKYELKKFVAHPNCQQQLLSIWYENLSGLRQQTTAVKLLVVLGVVVGLPI 387

  Fly   354 YCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKK----E 414
            ..|:|..||:.:.|:::|.||:||:.||:|:..||.:||:  ..||    |..||:.:..    :
Zfish   388 LALLYWIAPSSKLGKIIRGPFLKFVAHAASFTIFLGLLIM--NAAD----RFEGTSLLPNMTIHD 446

  Fly   415 LAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCL 479
            ...|..|.:....:.:|::::.:|:|.:|.|.:||:::|.:.||...||.:||...:::|:....
Zfish   447 HPSQLFRMKTTPFTWMEMLIISWVVGMIWAECKEIWSLGPREYLLEPWNLLDFGMLAIFVTSFIA 511

  Fly   480 RAFAYIQ-------------QATEIARDPQMAY--IPREKWHDFDPQLIAEGLFAAANVFSALKL 529
            |..|:..             ..:.|....::.|  :.|..|...|||||:|||:|.|.|.|..::
Zfish   512 RFMAFYHANVAQNYVDKRYTDLSNITLPLEIEYYRLARVHWVPSDPQLISEGLYAIAVVLSFSRI 576

  Fly   530 VHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEA 594
            .::...|...|||||||||.|.||.||..|:.:|..||..|:..|..|:...:::..
Zfish   577 AYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKQNGA-------- 633

  Fly   595 DWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIV 659
                          |..:.||.::||||.||:..:....::....:....|.:::|.|:|..|||
Zfish   634 --------------FTTVEESFKTLFWAIFGLSEVKSVVINNGHKFIENIGYVLYGVYNVTMVIV 684

  Fly   660 LLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVIRIFRKSSKT 724
            |||:||||::||:..|::.:|.||||||.|||.||||:..|||.|||::||.|.||.:..:..:.
Zfish   685 LLNMLIAMINNSFQEIEDDADVEWKFARAKLWFSYFEEGGTLPVPFNLIPSPKSVISLAMRLKRL 749

  Fly   725 I--------------------DRQRSKKRKEQEQFSEYDNIMRSLVWRYVAAMHRKFENNPVSED 769
            :                    .:|:....|.....|.|..||:.|:.|||.......|.:.|:|.
Zfish   750 LLIPLHRHKEDLKEDTELNESGKQKESSEKNSPHTSRYQRIMKRLIKRYVIKAQTDKEGDEVNEG 814

  Fly   770 DINEVKSEINTMRYEMLEIFENSGMDVSSANKKERQPRP-----RRIKVWERRLMKGFQV 824
            ::.|:|.:|:::|:|:||             :|.||...     ||:   |.||:..:::
Zfish   815 ELKEIKQDISSLRFELLE-------------EKSRQTEELAELVRRL---EERLISQYKI 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	274/787 (35%)
		ANK	48..195	CDD:238125	56/158 (35%)
		ANK repeat	78..114	CDD:293786	17/37 (46%)
		ANK repeat	134..177	CDD:293786	15/42 (36%)
		TRP_2	187..246	CDD:285535	26/58 (45%)
		DUF2031	<706..>805	CDD:299055	27/118 (23%)
trpc6b	XP_002665445.2	trp	50..829	CDD:273311	277/793 (35%)
		ANK	73..206	CDD:238125	46/136 (34%)
		ANK repeat	100..131	CDD:293786	12/30 (40%)
		ANK repeat	179..210	CDD:293786	13/30 (43%)
		TRP_2	220..279	CDD:285535	26/58 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.870