DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trpc3

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_001276813.2	Gene:	trpc3 / 101887082	ZFINID:	ZDB-GENE-140129-1	Length:	902	Species:	Danio rerio

Alignment Length:	813	Identity:	294/813 - (36%)
Similarity:	449/813 - (55%)	Gaps:	100/813 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMG--V 103
            ||::||.|.|.|::|.||::|:::|.   :|:||||.:|:..|.||:.||:||:.|||:...  .
Zfish    94 EEERFLDAAEYGNIPVVRKMLEESLT---LNVNCMDYMGQNGLQLAVGNEHLEVTELLLRRDNLA 155

  Fly   104 ETKDALLHAINAEFVEAVELLLEH------EELI-----YKEGEPYSWQKVDINTAMFAPDITPL 157
            ...||||.||:..:|..||.||.|      |.|.     .::.:.||:   |.:...|:|||||:
Zfish   156 RVGDALLLAISKGYVRIVEALLGHPSFGNGERLTRSPCELQDDDFYSY---DEDGTRFSPDITPI 217

  Fly   158 MLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICL 222
            :||||...:|::.:||.:||.:..|||..|.|.:|.....:||..||.||:|.||.|.||:.:.|
Zfish   218 ILAAHCQKYEVVHMLLLKGARIERPHDYFCKCADCTEKQRKDSFSHSRSRINAYRGLASPAYLSL 282

  Fly   223 TSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMS 287
            :|.||::||.:||.||..||..|:|.|::|..|..||:.|.|.:||..|.:.|:..|||.|.. :
Zfish   283 SSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVS-A 346

  Fly   288 SYEPGD--RMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVL 350
            ..|.|.  |..|:|:..||.|:.||||||.|.||.|.:|||:.|.|.|.::...|.:.:..||:.
Zfish   347 ELEEGQHHRSLLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTTAVKCLVVLVVALG 411

  Fly   351 FPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKEL 415
            .||..:.|..||..:.|:::|.|||||:.||:|::.||.:|:.   .|.|.|..|  ||.....:
Zfish   412 LPLLAVGYWFAPCSKLGKILRSPFMKFVAHAASFIIFLCLLVF---NASDRFEGI--TTLPNVTV 471

  Fly   416 AEQEL---RQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVM 477
            .:..|   |.:....|..|::::::|.|.:|.|.:|::..|.:.|:..:||.:||...|::::..
Zfish   472 TDHPLQIFRVKTTQFSWTEILIMVWVAGMMWSECKELWTEGPREYIMQLWNVLDFGMLSIFIAAF 536

  Fly   478 CLRAFAYIQ--QATEI------ARDPQMAYIP---------REKWHDFDPQLIAEGLFAAANVFS 525
            ..|.||::|  :|.:.      |.|..|..:|         |:||...|||||:|||:|.|.|.|
Zfish   537 TARFFAFMQAMKAQKYVDEKIHAPDLSMVTLPPDVRYFTYARDKWLPSDPQLISEGLYAIAVVLS 601

  Fly   526 ALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLP 590
            ..::.::...|...|||||||||.|.||.||..::.:|..||..|:..|..|:...:     |.|
Zfish   602 FSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAK-----VNP 661

  Fly   591 GGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVI 655
            .                 |..:.||.::|||:.||:..:....|.....:....|.:::|.|:|.
Zfish   662 A-----------------FTTVEESFKTLFWSIFGLSEVSSVVLKYDHKFIENIGYVLYGIYNVT 709

  Fly   656 NVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPS-------VKW 713
            .|:||||:||||:::||..|::.:|.||||||:|||:|||::..||||||:::||       ||.
Zfish   710 MVVVLLNMLIAMINSSYQEIEDDADVEWKFARSKLWLSYFDNGKTLPPPFSIVPSPKSFYLCVKR 774

  Fly   714 VIRIFR-----------------KSSKTIDRQRSKKRKEQEQF-------SEYDNIMRSLVWRYV 754
            ::.:.|                 ||...:..|.|.:..:...|       :.|..||:.|:.|||
Zfish   775 LVNLLRCRRRRLKKDVELGMDNSKSKLNLFTQSSMRMTDSHSFNSILNQPTRYQQIMKRLIKRYV 839

  Fly   755 AAMHRKFENNPVSEDDINEVKSEINTMRYEMLE 787
            .......||:.|:|.::.|:|.:|:::|||:||
Zfish   840 LKAQVDKENDEVNEGELKEIKQDISSLRYELLE 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	286/801 (36%)
		ANK	48..195	CDD:238125	62/159 (39%)
		ANK repeat	78..114	CDD:293786	16/37 (43%)
		ANK repeat	134..177	CDD:293786	16/42 (38%)
		TRP_2	187..246	CDD:285535	27/58 (47%)
		DUF2031	<706..>805	CDD:299055	29/113 (26%)
trpc3	NP_001276813.2	trp	78..869	CDD:273311	290/808 (36%)
		ANK	101..233	CDD:238125	52/137 (38%)
		ANK repeat	128..159	CDD:293786	11/30 (37%)
		ANK repeat	206..241	CDD:293786	15/34 (44%)
		TRP_2	247..306	CDD:285535	27/58 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910