DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trpc1

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_002937145.3	Gene:	trpc1 / 100497011	XenbaseID:	XB-GENE-1004978	Length:	896	Species:	Xenopus tropicalis

Alignment Length:	828	Identity:	299/828 - (36%)
Similarity:	465/828 - (56%)	Gaps:	105/828 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GVSSG---------VSHASSAPKSVGGCCVPLGLPQPLLLEEKKFLLAVERGDMPNVRRILQKAL 65
            |||:|         .|..||:|...........:.:...|:|:.||||.|:||...|:::|::.
Frog   110 GVSNGSSVIMAALYQSTDSSSPNKFLALKDVREVKEETTLDERLFLLACEKGDYYMVKKLLEEN- 173

  Fly    66 RHQHININCMDPLGRRALTLAIDNENLEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEEL 130
            ..:.:|||.:|.|||.|:|::|:||||::::||:..|.::.||||.||::|.|.||::||.|:.
Frog   174 SSEELNINSVDVLGRNAITISIENENLDILQLLLNYGCQSTDALLVAIDSEVVGAVDILLNHQP- 237

  Fly   131 IYKEGEPYSW-------------QKVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVP 182
                    .|             |..:.:|.|   |:.|::||||:||:|||.:||.:..::|.|
Frog   238 --------KWRTRPTIVKLMERIQNPEYSTTM---DVAPVILAAHRNNYEILTMLLKQDVSLPKP 291

  Fly   183 HDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQE 247
            |.:.|.|..|.....:||||||..|::|||.|.||:||.||..|||:.||:||.:|:.|:|.|.|
Frog   292 HAVGCECTLCTAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVE 356

  Fly   248 CKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGD-------RMSLTRLVQAIS 305
            .:::|.:|.::|:.||.|||.|.|.|.||.:|||:   .||.||.|       ||:|:||..||.
Frog   357 FRNDYEELAQKCKTFAKDLLAQARNSRELEVILNH---QSSDEPVDKRGLLEERMNLSRLKLAIK 418

  Fly   306 YKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLM 370
            |.||:||:.||.||.|:::|:..:.|:|||....|::.:..|.:.:|:..:.|:.||..:.|:::
Frog   419 YNQKEFVSQSNCQQFLNTVWFGQMAGYRRKHTCKKILIVLTVGIFWPVLSVCYLLAPKSQVGRII 483

  Fly   371 RKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVV 435
            ..|||||:||.:||..||.:|.|.|...::|          ||       ...|....:::.:::
Frog   484 HTPFMKFIIHGASYFTFLLLLNLYSLVYNED----------KK-------NTMGPALERIDFLLI 531

  Fly   436 MYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATEIARDPQMAYI 500
            |::||.||.:|:.::..|::.:|....|.:.|:.||||::...|:..|: .:...||.
Frog   532 MWLIGMVWSDVKRLWYDGLEDFLEESRNQLSFVMNSLYLATFALKVVAH-NKFHSIAE------- 588

  Fly   501 PREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLF 565
             |:.|..|.|.|:||||||..||.|.|:|..:::.:..|||||||:|:|:.|..||..::.||||
Frog   589 -RKDWDAFHPTLVAEGLFAFGNVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLF 652

  Fly   566 AFACGLNQLLWY---FAALEKSKCYVLPGGEADWGSHGDSCMKWRR--FGNLFESSQSLFWASFG 625
            :|..||.||  |   :...|:..|.            |..|.:...  |.:...:..:|||..|.
Frog   653 SFTIGLTQL--YDKGYTTNEQKDCV------------GIFCEQQSNDAFHSFTGTCYALFWYIFS 703

  Fly   626 M--VGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFART 688
            :  |.|.....|..:....|.|.|:.|:|:|:.||||..||:||:..|:.:|..|.|.||||||.
Frog   704 LAHVALFVTRFSFSEELQSFVGALIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARA 768

  Fly   689 KLWMSYFEDSATLPPPFNVLPSVKWVIRIFRKSSK---------TIDRQRSKKR---KEQEQFSE 741
            |||:|||:|..|||||||::||.|.:..:|...||         .:.||.|.|.   ..|::...
Frog   769 KLWLSYFDDKCTLPPPFNIVPSPKTICYLFNSISKWICSHTTTGRVKRQNSLKEWKSLRQKRDEN 833

  Fly   742 YDNIMRSLVWRYVAAMHRKFEN-NPVSEDDINEVKSEINTMRYEMLEI 788
            |..:|..||.||:.:|.:|.:: :..:.:::||::.:::..|.||.::
Frog   834 YQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEMRDL 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	284/775 (37%)
		ANK	48..195	CDD:238125	59/159 (37%)
		ANK repeat	78..114	CDD:293786	18/35 (51%)
		ANK repeat	134..177	CDD:293786	17/55 (31%)
		TRP_2	187..246	CDD:285535	30/58 (52%)
		DUF2031	<706..>805	CDD:299055	25/96 (26%)
trpc1	XP_002937145.3	trp	151..877	CDD:273311	288/781 (37%)
trpc1	XP_002937145.3	ANK repeat	186..213	CDD:293786	13/26 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920