DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trpl and trpc5

DIOPT Version :9

Sequence 1:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_017952480.1	Gene:	trpc5 / 100493720	XenbaseID:	XB-GENE-1013348	Length:	982	Species:	Xenopus tropicalis

Alignment Length:	1029	Identity:	399/1029 - (38%)
Similarity:	583/1029 - (56%)	Gaps:	159/1029 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VPLGLPQ---PLLLEEKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNEN 91
            :||.:.:   .|..|||.:|:|||:||..:|:..|::|..:.:|||||||||||.||.:||:|||
Frog    18 IPLQIVRAEAELSQEEKAYLIAVEKGDYASVKHALEEAEIYYNININCMDPLGRSALLIAIENEN 82

  Fly    92 LEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKV-----DINTAMFA 151
            ||::|||:...:...||||:||..|.|.||||||.|.       :|...::|     |...:.|.
Frog    83 LEIMELLLSHNIYVGDALLYAIRKEVVGAVELLLSHR-------KPSGEKQVPTLMMDTQFSEFT 140

  Fly   152 PDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCS 216
            |||||:|||||.||:||:::|:.|...:|.||.|||.|.|||..:..||||||.||:|||:||.|
Frog   141 PDITPIMLAAHTNNYEIIKLLVQRRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALAS 205

  Fly   217 PSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILN 281
            ||||.|:|.|||:|||:|.|||:.|:..|.|.|:||.:|.:||:|||.|||||.|:|.||.||||
Frog   206 PSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKKFAKDLLDQARSSRELEIILN 270

  Fly   282 Y-DPQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIA 345
            : |.|....:|.....|.:|..||.|.||:|||..|.||||:::||||.||:|||....|::...
Frog   271 HRDDQSEELDPQKCHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWAVKLVTCI 335

  Fly   346 QVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTR 410
            .:.:|||:..:.|:.||..|.|..::|||:||:.|.:|||.|||:|:|.||
Frog   336 TIGLLFPVLSVAYLIAPKSRLGLFIKKPFIKFICHTASYLTFLFLLLLASQ-------------- 386

  Fly   411 MKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVS 475
               .:...||..:|..|:.:|.:::.:|:||:|.|::|::..|...|:.:.||.:||..||||::
Frog   387 ---HIVRTELHMQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFNEYVHDWWNLMDFAMNSLYLA 448

  Fly   476 VMCLRAFAYIQQATEIARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLG 540
            .:.|:..||::         .....|||:|..:.|.||||..||.:|:.|:|:|:.||:.|.|||
Frog   449 TISLKIVAYVK---------YNGSKPREEWDMWHPTLIAEAFFAISNILSSLRLISLFTANSHLG 504

  Fly   541 PLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYF---AALEKSKCYVLPGGEADWGSHGDS 602
            |||||||||::||:||.|||.|||.|||.|||||.:|:   |:.|.:.|            .|..
Frog   505 PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETSASEEPNNC------------KGIR 557

  Fly   603 CMKWRR-FGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIA 666
            |.|... |..|||:.|||||:.||::.|....:.....:|.|.|..|||:|:||:::||||:|||
Frog   558 CEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIA 622

  Fly   667 MMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPS-------VKWV---IRIFRKS 721
            ||:|||.:|.:|:|.||||||||||||||::.||:|||||::.|       .|||   :...:.|
Frog   623 MMNNSYQLIADHADIEWKFARTKLWMSYFDEGATMPPPFNIIASPKSIWYFCKWVRYKLCPGKNS 687

  Fly   722 SKTIDRQRSKKRKEQEQFSE-------YDNIMRSLVWRYVAAMHRKFENNP-VSEDDINEVKSEI 778
            .:.|.:|....:...|:.::       |..::|:||.||||||.|..:.|. ::|::..|:|.:|
Frog   688 EEDIQKQHENLKTFTERHADNLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDI 752

  Fly   779 NTMRYEMLEIFEN----------SGMDVSSANK-KERQPRPRRIKVWERRLMKGFQV-------- 824
            ::.|||:|::..|          |..:||..:: .|.:|:.:.:........|.|.|
Frog   753 SSFRYEVLDLLGNRKPPRRSYSTSSTEVSQKDEATEERPKAKSVSFGISNKKKDFNVSALIKTMS 817

  Fly   825 -------APVQNGCELDAF---GNVNGQGEMQEIKVESIPSKPAKETAKERFQRVARTVLLQSTT 879
                   ||..||....:|   ||          |::.:.|     :.||.|:|:.   ||.|
Frog   818 GIEIVEDAPKSNGINKRSFIRNGN----------KIQRLSS-----SKKESFKRLG---LLFS-- 862

  Fly   880 HKWNVVLRAAKDSQIGRCTKNERKSLQNLGRAIEEAKRLIMLNPGCPSGRESPIRIEFEDEKTST 944
             |.|           |..|:...:.:..:...:.:...:........:|:|:    |....:|:
Frog   863 -KMN-----------GHVTEPASEPVYTISDGVVQPHAMWQDLQHPQTGQEA----ERSVSETN- 910

  Fly   945 LLELLNQISAE---ISDSEKPKIRPIWRPPLKTVP---ARAMAANNTRSLTAPE 992
                ||::|.:   :..|.:       .||:.|..   |..:.::|||.:.:.|
Frog   911 ----LNEVSHDGSIVGQSNE-------NPPICTNSLHCASNLCSSNTRLIDSTE 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	344/763 (45%)
		ANK	48..195	CDD:238125	76/151 (50%)
		ANK repeat	78..114	CDD:293786	20/35 (57%)
		ANK repeat	134..177	CDD:293786	20/47 (43%)
		TRP_2	187..246	CDD:285535	36/58 (62%)
		DUF2031	<706..>805	CDD:299055	34/127 (27%)
trpc5	XP_017952480.1	trp	17..758	CDD:273311	351/784 (45%)
		ANK repeat	35..67	CDD:293786	14/31 (45%)
		ANK repeat	69..94	CDD:293786	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	784	1.000	Inparanoid score	I514
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm9358
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060