Protein Alignment trpl and trpc4

DIOPT Version :9

• Sequence 1: NP_476895.1
• Gene: trpl / 36003
• FlyBaseID: FBgn0005614
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_002939629.3
• Gene: trpc4 / 100485338
• XenbaseID: XB-GENE-1013618
• Length: 969
• Species: Xenopus tropicalis
• Alignment Length: 1017
• Identity: 395/1017 - (38%)
• Similarity: 568/1017 - (55%)
• Gaps: 149/1017 - (14%)

  Fly    42 EKKFLLAVERGDMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNENLEMVELLVVMGVETK 106
            ||.:|.|||:||..:|::.|::|..:..|||||:|||||.||.:||:|||||::|||:...|...
 Frog    33 EKAYLSAVEKGDYASVKQALEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSYNVYVG 97

  Fly   107 DALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKV-----DINTAMFAPDITPLMLAAHKNNF 166
            |||||||..|.|.||||||.|:       :|...::|     |...:.|.|||||::||||.||:
 Frog    98 DALLHAIRKEVVGAVELLLNHK-------KPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNY 155

  Fly   167 EILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITA 231
            ||::.|:.:|.:||.||::||.|.|||..:..||||||.||:||||||.|||||.|:|.||.:||
 Frog   156 EIIKHLVQKGVSVPRPHEVRCNCVECVSGSDVDSLRHSRSRLNIYRALSSPSLIALSSEDPFLTA 220

  Fly   232 FQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGDRMS 296
            |||||||:.|:..|.|.||||.:|..||::||.|||||||:|.||.|||||.......:..:...
 Frog   221 FQLSWELQELSKVENEFKSEYEELSSQCKQFAKDLLDQTRSSRELEIILNYRDDGGLLDDSNGND 285

  Fly   297 LTRLVQAISYKQKKFVAHSNIQQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCA 361
            |.||..||.|:||:|||..|.||||:|.|||..||:||:..|.|::....|.:|||.:...|:.|
 Frog   286 LARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWVVKMVTCVIVGLLFPAFSCCYLIA 350

  Fly   362 PNCRTGQLMRKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQT 426
            |....|..:||||:||:.|.:|||.|||:|:|.||..:            |.|..:      |..
 Frog   351 PKSTFGLFIRKPFIKFICHTASYLTFLFLLLLASQNIN------------KTESLQ------GPA 397

  Fly   427 PSKLELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATEI 491
            |:.:|.:::.:|:||:|.|:::::..|.:.|:.:.||.:||:.||||::.:.|:..||::...:
 Frog   398 PTIVEWMILPWVLGFIWGEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKFHGQ- 461

  Fly   492 ARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKF 556
             |:       |.:|..|.|.|:||.:||.||:||:|:|:.||:.|.||||||||||||::||:||
 Frog   462 -RN-------RAEWEMFHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKF 518

  Fly   557 FFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRR-FGNLFESSQSLF 620
            .|||.|||.|||.|||||.:|:.|..||.           |..|..|.|... |..|||:.||||
 Frog   519 LFIYCLVLLAFANGLNQLYFYYEADAKSS-----------GCKGIRCEKQNNAFSTLFETLQSLF 572

  Fly   621 WASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKF 685
            |:.||::.|....:.....:|.|.|..|||:|:||:::||||:|||||:|||.:|.:|:|.||||
 Frog   573 WSIFGLINLYVTNVDPKHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKF 637

  Fly   686 ARTKLWMSYFEDSATLPPPFNVLPS-------VKWVIRIFRKSSKTIDRQRSKKRKEQ------- 736
            |||||||||||:..|||.|||::||       :||:       .|.|.:::.|::.|.
 Frog   638 ARTKLWMSYFEEGGTLPTPFNIIPSPKSLWYLIKWI-------RKQICKKKMKRKPESFGAIGRR 695

  Fly   737 -----EQFSEYDNIMRSLVWRYVAAMHR--KFENNPVSEDDINEVKSEINTMRYEMLEIFENSGM 794
                 .:.:.|..:|::||.||||||.|  |.|.. ::|::..|:|.:|::.|:|:|.:.:.:..
 Frog   696 AADNLRRHNHYQEVMKNLVKRYVAAMIRDAKTEEG-LTEENFKELKQDISSFRFEVLGLLKGNKF 759

  Fly   795 DVSSANKKERQPRPRRIKVWERRLMKGFQVAPVQNGCELDAFGNVNGQGEMQEIKVESIPSKPAK 859
            ::.|:...                                     ||.|::||.:.:|...:...
 Frog   760 NIQSSKMN-------------------------------------NGIGDIQETEEKSKIKEKRS 787

  Fly   860 ETAKERFQRVARTVLLQSTTHKWNVVLRAAKDSQIGRCTKNER--------KSLQNLGRAIEEAK 916
            .|.|:.|.....|.::    |..:.|:.    |.:.....|..        |..|.....:.:.|
 Frog   788 RTQKKNFSLFDITTMI----HPKSAVIA----SDVHNSVSNGSALLASELVKEKQRKNSFVTDIK 844

  Fly   917 RLIMLNPGCPSGRESPIRIEFEDEKT--STLLELLNQISAEISDS--------EKPKIRPIWRPP 971
            ...:.:....|....||      .||  |...|:.||...|:.|:        .:|....:....
 Frog   845 SFGLFHKRSKSNFSDPI------SKTIYSVSEEVANQQDMELGDNTTDLQVKESEPASCELNVNK 903

  Fly   972 LKTVPARAMAANNTRSLTAPELKISRKSSPAPTPTPTPGVSH 1013
            |....|.:.::.||..:.:|:...|:.||.|.....|..:.|
 Frog   904 LTEQYALSPSSVNTSEIPSPQPSDSQHSSVALNEHSTDALKH 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trpl	NP_476895.1	trp	48..784	CDD:273311	349/762 (46%)
		ANK	48..195	CDD:238125	76/151 (50%)
		ANK repeat	78..114	CDD:293786	22/35 (63%)
		ANK repeat	134..177	CDD:293786	18/47 (38%)
		TRP_2	187..246	CDD:285535	38/58 (66%)
		DUF2031	<706..>805	CDD:299055	30/119 (25%)
trpc4	XP_002939629.3	trp	17..749	CDD:273311	352/768 (46%)
		ANK repeat	69..133	CDD:293786	34/70 (49%)
		ANK repeat	135..166	CDD:293786	15/30 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	784	1.000	Inparanoid score	I514
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm9358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970