DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZBTB41 and CG42726

DIOPT Version :9

Sequence 1:	NP_919290.2	Gene:	ZBTB41 / 360023	HGNCID:	24819	Length:	909	Species:	Homo sapiens
Sequence 2:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	125/512 - (24%)
Similarity:	197/512 - (38%)	Gaps:	143/512 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   422 HKCPYCNKLHASKKTLAK----HVK-RFHPENAQEFISIKKTKSESWKC------DICKKSFTR- 474
            :|||.||.....:..|..    |.| |         :.:....|:..:|      ||.:...|:
  Fly     2 NKCPRCNCDATGQNRLVTDSCGHTKCR---------LCLVADVSDCLECRVARSVDIQETQETQA 57

Human   475 RPHLEEHMILHSQDKPFKCTYCEEHFKSRFARLKHQEKFH-------LGPFPCDICGRQFNDTGN 532
            |...::.:|:  .||.:.||.|.:.|:||     .|:.:|       |..|.|..|||:|..:.:
  Fly    58 RTSADKRIIV--TDKGYHCTVCNKDFRSR-----TQQYYHLTCGNDLLKKFNCKECGRRFATSSH 115

Human   533 LKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCSICGQSFRHGSSYRLHLRVH 597
            ||.|: .:|..:.|.:|.:|.||.::...|:.|:..|:.|| |||.||.:.||..||...||.:|
  Fly   116 LKYHL-MSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEK-HLCPICQKVFRRKSSLASHLAIH 178

Human   598 HD-DKRYECDECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRRDHLTVHYKSVHLGEKVWQ 661
            .| ..:::|:.|.|.|....:|.:|.:.|......
  Fly   179 SDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIR------------------------------ 213

Human   662 KYKATFHQCDVCKKIFKGKSSLEMHFRTHSGEKPYKCQICNQSFRIKKTLTKHLVIHSDARPFNC 726
                  |.|.||:|.|..:::|.:|.:.||..:...|.:|.:|:.....|.:||..|..|..:.|
  Fly   214 ------HMCKVCQKSFLRQTTLRLHMKRHSNRERQSCSLCGKSYNDPDALGRHLRQHKTAERYRC 272

Human   727 QHCNATFKRKDKLKYHIDHVHEIKSPDDPLSTSEEKLVSLPVEYSSDDKIFQTETKQYMDQPKVY 791
            ..|:.|..|||.:..|:..:|    |....:::.|                       |..|:..
  Fly   273 IQCDITINRKDNMLRHLRSMH----PGCAFASTVE-----------------------MVTPRSS 310

Human   792 QSEAKTMLQNVSAEVCVPVTLVPVQMPDTPSDLVRHTTTLPPSSHEILSPQP----QSTDYPRAA 852
            ..||.|      ||             :.||..||:.:.:    ..:.:.:|    |||..|...
  Fly   311 AQEATT------AE-------------ERPSQTVRYNSVI----QSVGNVEPVMLLQSTPLPSQL 352

Human   853 DLAFLEKYTLTPQPANIVHPVRPEQMLDPREQSYLGTLLGLDSTTGVQNISTNEHHS 909
            ....:||....|:     |...|:.|.:...|.|...:|.||          ||.:|
  Fly   353 PELQMEKGKAVPE-----HLPLPDVMPEENVQLYRKIILDLD----------NEEYS 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB41	NP_919290.2	BTB_POZ_ZBTB41	66..179	CDD:349535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344
		C2H2 Zn finger	363..383	CDD:275368
		C2H2 Zn finger	391..411	CDD:275368
		C2H2 Zn finger	424..442	CDD:275368	6/21 (29%)
		C2H2 Zn finger	465..485	CDD:275368	6/26 (23%)
		C2H2 Zn finger	493..510	CDD:275368	6/16 (38%)
		C2H2 Zn finger	520..541	CDD:275368	8/20 (40%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	9/19 (47%)
		zf-C2H2	603..625	CDD:395048	6/21 (29%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	633..651	CDD:275368	0/17 (0%)
		C2H2 Zn finger	670..687	CDD:275368	6/16 (38%)
		C2H2 Zn finger	698..718	CDD:275368	6/19 (32%)
		C2H2 Zn finger	726..743	CDD:275368	6/16 (38%)
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	8/24 (33%)
		C2H2 Zn finger	103..123	CDD:275368	8/20 (40%)
		COG5048	<112..288	CDD:227381	58/213 (27%)
		C2H2 Zn finger	131..151	CDD:275368	6/19 (32%)
		Chordopox_A33R	151..>254	CDD:283591	36/139 (26%)
		C2H2 Zn finger	158..178	CDD:275368	9/19 (47%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	7/19 (37%)
		C2H2 Zn finger	244..264	CDD:275368	6/19 (32%)
		C2H2 Zn finger	272..290	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010