DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and STK17A

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_004751.2	Gene:	STK17A / 9263	HGNCID:	11395	Length:	414	Species:	Homo sapiens

Alignment Length:	337	Identity:	122/337 - (36%)
Similarity:	190/337 - (56%)	Gaps:	24/337 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKRNVEREVEIMNSL-------QHHLIIQLYA 96
            |:|||||..|.||..|.:|.:.||||:    |:.::..:..:||::.:       .:..:|.|:.
Human    66 ELGRGKFAVVRKCIKKDSGKEFAAKFM----RKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHE 126

  Fly    97 AYEYQKMMCVVLELIEGGELFDR-VVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLKPEN 160
            .||....|.:|||...|||:||: |.|.|....|:..:..:||:.|.:.|:|...:|||||||:|
Human   127 VYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQN 191

  Fly   161 ILVLTQK--GNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVICYV 223
            ||:.::.  |: |||:||||:|.....:.||.:.||||:||||::::|.||..|||||:||:.||
Human   192 ILLTSESPLGD-IKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYV 255

  Fly   224 LISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAECMKHKW 288
            :::|:|||:|.:..||..|::.....:.:|.|:.:|...:|||..||.|....|.||.||:||.|
Human   256 MLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPW 320

  Fly   289 LQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIEDEDDEEEVAVQ-----QA 348
            |.|    ::...|..:...|..::.............|..|.:||.|....||.:.|.     |.
Human   321 LTQ----SSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQC 381

  Fly   349 KQKDQQQDEELA 360
            :|.::::.|:.|
Human   382 RQSEKEKMEQKA 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	105/259 (41%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	104/258 (40%)
STK17A	NP_004751.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		STKc_DRAK1	51..321	CDD:271099	105/259 (41%)
		S_TKc	64..321	CDD:214567	105/259 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810