DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and DCLK1

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001317000.1	Gene:	DCLK1 / 9201	HGNCID:	2700	Length:	740	Species:	Homo sapiens

Alignment Length:	376	Identity:	102/376 - (27%)
Similarity:	171/376 - (45%)	Gaps:	56/376 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDSEPEGVLEPAFPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPK 69
            :|...|.|.|..|.: ..||.      :.|.|...:|.|.|..|.:|.:::...:.|.|.:...|
Human   368 NDGPGEEVSEEGFQI-PATIT------ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSK 425

  Fly    70 REDKRN-VEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCR 133
            ...|.: ::.||.|:..::|..|:.|....:....:.:|:||::||:|||.:.... ..|||...
Human   426 CRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTN-KYTERDAS 489

  Fly   134 VFIRQVCEAMAFIHGNGIVHLDLKPENILVLT-QKGNR-IKIIDFGLARKFDPDKRLRVLFGTPE 196
            ..:..:..|:.::|...|||.|:||||:||.. |.|:: :|:.|||||...|..  |..:.|||.
Human   490 GMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP--LYTVCGTPT 552

  Fly   197 FVAPEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETM--SNVTIAKYDFEDECFNGIS 259
            :||||::.........|:|:.|||.|:|:.|..||.|..|.:.:  ..:.:.:.||....::.:|
Human   553 YVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVS 617

  Fly   260 PECLDFIAKLLAKDLSTRMTAAECMKHKWLQQ----------------------RPATAATATPI 302
            ....:.|..:|..|:..|.:|.:.::|.|:..                      .|...:||..:
Human   618 DSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGV 682

  Fly   303 TKAASAA---------------SKSRLKS-VSPVTAPSES---SEDSTETI 334
            :..|:.|               .:||.|: .:|....|||   |..|:||:
Human   683 SVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETV 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	78/259 (30%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	76/253 (30%)
DCLK1	NP_001317000.1	DCX1_DCLK1	55..143	CDD:340660
		DCX2	182..265	CDD:340589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..378		3/9 (33%)
		STKc_DCKL1	383..650	CDD:271085	81/275 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..740		11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900