DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and TDA1

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_014019.1	Gene:	TDA1 / 855336	SGDID:	S000004905	Length:	586	Species:	Saccharomyces cerevisiae

Alignment Length:	595	Identity:	130/595 - (21%)
Similarity:	235/595 - (39%)	Gaps:	150/595 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NVDAH----KHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKRN----VEREVEIM 83
            |.||.    |:......:|.|.|..|.:|.:.......|.|.:   |::..:|    ::||.:::
Yeast    28 NADAQTFKCKYVTNHNSLGDGNFSVVKECMNIHTKDLYAMKLI---KKQTVKNKIQLIQREFDLL 89

  Fly    84 NSLQ-------------------HHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTE 129
            .|:.                   ||.|:||:..:|....:.::.:|.:.|:|::::|:::.:..|
Yeast    90 RSISEKIRDMEKKNEHSLDIFEGHHHILQLFDYFETADNIVLITQLCQKGDLYEKIVENQCLDLE 154

  Fly   130 RVCRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNRIK--------------------II 174
            .....:...:...:.|:|..||||.|||.||:|...:.....|                    :.
Yeast   155 TQVTSYCACLVSVLEFLHSQGIVHRDLKAENVLFRLRVNENEKNLQGEHHGDFKYDLLAHDLVLA 219

  Fly   175 DFGLARKFDPDK--RLRVLFGTPEFVAPEVVNFDCI------------SYG--TDMWSVGVICYV 223
            |||||.:::..|  .|:...||..::|||:|....:            .||  .|:|::||:.|.
Yeast   220 DFGLAAEYNTSKVNSLKEFVGTISYIAPEIVKCKGVGEMTPDQVGKLDKYGCPVDIWALGVLTYF 284

  Fly   224 LISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECL-DFIAKLLAKDLSTRMTAAECMKHK 287
            :..|.:||....|.||:..::...|..:::..:....|.. :|:......|.:.|.:|....:|.
Yeast   285 MAFGYTPFDCTTDDETLECISKCDYYVDEQMMHDPKYEQFWNFVQCCFTIDPAVRRSAKNLKQHP 349

  Fly   288 WLQQRPATAATA----TP-------ITKAASAASKSRLKSVSPVTAPSESSEDSTETIEDED-DE 340
            :::...||:.:.    ||       |.:.:|.||...|:|      ||:|.:.:|....:.| ..
Yeast   350 FIKDYFATSNSLNTKDTPNFSFHPTIRRVSSTASMHTLRS------PSKSRKTTTLAYLNMDGGS 408

  Fly   341 EEVAVQQAKQKDQQQDEELANLCGDAELENKE--LDATKDNLKNFIVRWETHPNSPYVFDVEGNV 403
            .|.:...:.:.|      |.:|..|..:.::|  |:..:|.||..:......|..  .||
Yeast   409 SETSTAFSSKMD------LPDLYVDRTINSRERSLNRIRDTLKKTLSMTSLKPAG--TFD----- 460

  Fly   404 IAPLSETSYPHPRRTHGADSLSSSR----------VCSPSP-----CDSISTLTDDERGDI---E 450
                    |.|..:  ...|||||:          |..|.|     .:...:.|.:.|.:.   :
Yeast   461 --------YLHANK--NGTSLSSSKSGLVKKNSTFVLDPKPPKNSLMNGCFSTTPESRSNFNTPK 515

  Fly   451 DLPEEDESRSAE---NE-----SPRSVATPINESREKLFPTVA-----TSSPSTPTPQHL--FNE 500
            .|..:..|.|.:   ||     :||:.:...|:       |.|     |::...|..:|.  |..
Yeast   516 TLSRQGSSTSVKKYVNEVDLLLTPRTASMSSND-------TTAINDYDTTNDKNPARKHAASFQV 573

  Fly   501 NFDEFSGSQS 510
            |.|:..|.::
Yeast   574 NVDDSDGDET 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	69/314 (22%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	69/308 (22%)
TDA1	NP_014019.1	STKc_CAMK	37..350	CDD:270687	70/315 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000