DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and CMK1

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_116669.1	Gene:	CMK1 / 850568	SGDID:	S000001910	Length:	446	Species:	Saccharomyces cerevisiae

Alignment Length:	464	Identity:	121/464 - (26%)
Similarity:	195/464 - (42%)	Gaps:	84/464 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KHYDVLGE-VGRGKFGTVYKCRDKANGLQLAAKFVPIPK--REDKRNVER---EVEIMNSLQHHL 90
            |.| |.|: :|.|.||.|.:.::...|..:|.|.: |.|  :.:|..:|.   |::|:..|.|..
Yeast    35 KKY-VFGKTLGAGTFGVVRQAKNTETGEDVAVKIL-IKKALKGNKVQLEALYDELDILQRLHHPN 97

  Fly    91 IIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLD 155
            |:.....:|.:....::.:|.:|||||||::.......|...|:.: ::..|:.::|...|||.|
Yeast    98 IVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILV-EILSAVKYMHSQNIVHRD 161

  Fly   156 LKPENILVLTQKG-NRIKIIDFGLARKFDPDKRLRVLF---GTPEFVAPEVVNFDCISYGTDMWS 216
            |||||:|.:.:.. :.:.:.|||:|::...|:.|  |:   |:..:|||||:..|......|:||
Yeast   162 LKPENLLYIDKSDESPLVVADFGIAKRLKSDEEL--LYKPAGSLGYVAPEVLTQDGHGKPCDIWS 224

  Fly   217 VGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNG-------------ISPECLDFIAK 268
            :|||.|.|:.|.|.|..|.           ..||.|||..|             :|.:...||.|
Yeast   225 IGVITYTLLCGYSAFRAER-----------VQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILK 278

  Fly   269 LLAKDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSE----- 328
            .|..|.|.|.||||.::..|:...........|..|....|.:....||..|....:..:
Yeast   279 ALNLDPSKRPTAAELLEDPWIICTELKTHNLLPGLKEGLDARQKFRNSVERVRLNMKIQKLRDLY 343

  Fly   329 -DSTETIEDEDDEEEV--AVQQAKQKDQQQDEELANLCGDAELENKELDATKDNLKNFIVRWETH 390
             :.||:..|.|:..:.  :|...|..|..|            |..|..:..:..||:
Yeast   344 LEQTESDSDFDEGSQANGSVPPLKATDTSQ------------LSKKLSEEEQSKLKS-------- 388

  Fly   391 PNSPYVFDVEGNVIAPLSETSYPHPRRTHGADSLSSSRVCSPSPCDSISTLTDDERGDIEDLPEE 455
                   ::.....|.|..|......:     .|:.:||||     |.|.|...:...:::..|:
Yeast   389 -------ELTSKAFAQLVNTVLAEKEK-----FLNINRVCS-----SDSDLPGSDIKSLDEAKEK 436

  Fly   456 DESRSAENE 464
            .|.:..:.|
Yeast   437 PEGKDTKTE 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	87/277 (31%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	84/270 (31%)
CMK1	NP_116669.1	STKc_CAMK	36..298	CDD:270687	87/277 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000