DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and Dclk2

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001344389.1	Gene:	Dclk2 / 70762	MGIID:	1918012	Length:	772	Species:	Mus musculus

Alignment Length:	423	Identity:	111/423 - (26%)
Similarity:	182/423 - (43%)	Gaps:	60/423 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PEGV----LEPAFPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPK 69
            ||||    ...:||:.:           .|.:...:|.|.|..|.:|.|:..|.:.|.|.:...|
Mouse   391 PEGVNGNRCSESFPLLE-----------KYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAK 444

  Fly    70 REDKRN-VEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCR 133
            ...|.: :|.||.|:..::|..||.|....|....:.:|:||::||:|||.:.... ..|||...
Mouse   445 CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSST-KYTERDGS 508

  Fly   134 VFIRQVCEAMAFIHGNGIVHLDLKPENILVLT-QKGNR-IKIIDFGLARKFDPDKRLRVLFGTPE 196
            ..:..:..|:.::|...|||.|:||||:||.. ..|.: :|:.|||||...:..  |..:.|||.
Mouse   509 AMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGP--LYTVCGTPT 571

  Fly   197 FVAPEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDI--ETMSNVTIAKYDFEDECFNGIS 259
            :||||::.........|:|:.|||.|:|:.|..||..||::  :....:...|.:|....::.|:
Mouse   572 YVAPEIIAETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNIT 636

  Fly   260 PECLDFIAKLLAKDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPS 324
            ....:.|:::|..::..|.||.|.:.|.|:..   .|:....:....:...|....:..|
Mouse   637 DSAKELISQMLQVNVEARCTAGEILSHPWVSD---DASQENNMQAEVTGKLKQHFNNALP----- 693

  Fly   325 ESSEDSTETIEDEDDEEEVAVQQAKQKDQQQDEELANLCGDAELENKELDATKDNLKNFIVRWET 389
              .::||.|        .|:|......|::.....:.||.|:...::|               :|
Mouse   694 --KQNSTTT--------GVSVIMNTALDKEGQIFCSKLCQDSSRPSRE---------------QT 733

  Fly   390 HPNSPYVFDVEGNVIAPLSETSYPHPRRTHGAD 422
            .|..|...:..    .||.....|.|..|.|.|
Mouse   734 SPVPPSAQEAP----PPLESPRPPGPPATSGCD 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	81/259 (31%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	80/253 (32%)
Dclk2	NP_001344389.1	DCX	67..157	CDD:214711
		DCX	191..279	CDD:214711
		PKc_like	407..665	CDD:328722	81/271 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900