DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and Dapk1

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	XP_036014050.1	Gene:	Dapk1 / 69635	MGIID:	1916885	Length:	1464	Species:	Mus musculus

Alignment Length:	970	Identity:	248/970 - (25%)
Similarity:	378/970 - (38%)	Gaps:	252/970 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LGEVGR------------GKFGTVYKCRDKANGLQLAAKFVPIPKREDK--------RNVEREVE 81
            ||.|.|            |:|..|.|||:|:.|||.||||  |.||..|        .::||||.
Mouse    26 LGSVSRHAEEEFVETGHVGQFAVVKKCREKSTGLQYAAKF--IKKRRTKSSRRGVSREDIEREVS 88

  Fly    82 IMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFI 146
            |:..::|..:|.|:..||.:..:.::|||:.||||||.:.:.| .|||.....|::|:...:.::
Mouse    89 ILKEIRHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEFLKQILSGVYYL 152

  Fly   147 HGNGIVHLDLKPENILVLTQK--GNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCIS 209
            |...|.|.|||||||::|.:.  ..||||||||||.|.|.....:.:||||||||||:||::.:.
Mouse   153 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLG 217

  Fly   210 YGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDL 274
            ...||||:|||.|:|:||.|||:|:...||::||:...||||:|.|...|....|||.:||.||.
Mouse   218 LEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDP 282

  Fly   275 STRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIEDEDD 339
            ..|||..:.::|.|::.:.    |...:::.|||.:..:.|..
Mouse   283 KKRMTIQDSLQHPWIKPKD----TQQALSRKASAVNMEKFKKF---------------------- 321

  Fly   340 EEEVAVQQAKQKDQQQDEELANLC--------GDAELENKELDATKDNLKNFIVRWETHPNSPYV 396
                    |.:|..:|...|.:||        ..:.:.....|.|.|...:|:::...|..:
Mouse   322 --------AARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAIN--- 375

  Fly   397 FDVEGNVIAPLSETSYPHPRRTHGADSLSSSRVCSPSP-----------CDSISTL-TDDERGDI 449
               :.||           |...|...||||..|..|:.           |.:|..| ...:||..
Mouse   376 ---DDNV-----------PGLQHLLGSLSSYDVNQPNKHGTPPLLIAAGCGNIQMLQLLIKRGSR 426

  Fly   450 EDLPEEDESRSA----------------ENESPRSVATPINESREKLFPTVA-----------TS 487
            .|:.::..|.:.                ||:.|..|.   ::|.|......|           .|
Mouse   427 IDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVK---DKSGETALHVAARYGHADVVQLLCS 488

  Fly   488 SPSTP--------TPQHLFNENFDEFSGSQSTAQ-----------QQRSMKSYLHTFDRRN-SDT 532
            ..|.|        ||.|.     ..:.|..|.|:           :.|..::.|.|...|. .|.
Mouse   489 FGSNPDFQDKEEETPLHC-----AAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDI 548

  Fly   533 TYLLGRRSSGERVNLADEIRKLSDHLLM----LAEINTKLG--------DANNNGSSSGAPADPP 585
            ...|...  |..:|.:|:...::.||.:    :..|.|.||        |.:.|.....|..|
Mouse   549 VECLAEH--GADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKD-- 609

  Fly   586 AAAAAAAAPVPTSTAPASVAPSGSTSSKTSEISQEGNRWTSKTTSSSS----WNRPTLKGGLFSQ 646
                 .:||:..:...||.         ..:||.:..|......:::.    .....|.|.....
Mouse   610 -----GSAPIVVALCEASC---------NLDISNKYGRTPLHLAANNGILDVVRYLCLMGANVEA 660

  Fly   647 ASSSSQSQSTYDDGKGKTKISSLSVRLQ---------QSIEETPKLSN-------GNSSSSKSLV 695
            .:|..::.......:....::.|..||:         |.:..|..|..       |:|.|.||
Mouse   661 LTSDGKTAEDLAKAEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKS-- 723

  Fly   696 QSQRKSTVQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSSNYIASNASNSISTSASNP 760
                 :.|:::.....|||..::..|.|:|      :|||...               |..|:.|
Mouse   724 -----TLVESLKCGLLRSFFRRRRPRLSST------NSTRFPP---------------SPLAAKP 762

  Fly   761 SSTGASNPITTSASNESASSRRAKFR--INQMSRDVPVGLPDTHQTVNLEEAANTTKDCLLHLLE 823
            :.:.:.|.:.....|.|..||...|.  :.:...:|.|. |..|...:.::.:....|.
Mouse   763 TVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVA-PSHHLHCSTDDQSTKAIDI------ 820

  Fly   824 KYNETRIRNPVGRHQSISVDWRVSDNLEYRSMSSINAFFQRHNPNGGGHNVRHIQAQLEE 883
               :....|.||   ..|| |..|.|..|.....   :|..::|.    ::..|...|||
Mouse   821 ---QNAYLNGVG---DFSV-WEFSGNPVYFCCYD---YFAANDPT----SIHIIVFSLEE 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	119/273 (44%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	117/270 (43%)
Dapk1	XP_036014050.1	PKc_like	35..297	CDD:419665	115/264 (44%)
		Ank_2	<360..431	CDD:423045	19/87 (22%)
		ANK repeat	400..431	CDD:293786	6/30 (20%)
		Ank_4	401..453	CDD:372654	7/51 (14%)
		ANK repeat	434..464	CDD:293786	5/32 (16%)
		Ank_2	450..>661	CDD:423045	44/236 (19%)
		ANK repeat	466..497	CDD:293786	6/30 (20%)
		ANK repeat	499..530	CDD:293786	6/35 (17%)
		ANK repeat	532..563	CDD:293786	7/32 (22%)
		PLN03192	<537..790	CDD:215625	58/298 (19%)
		ANK repeat	565..596	CDD:293786	6/30 (20%)
		ANK repeat	598..629	CDD:293786	8/46 (17%)
		ANK repeat	631..660	CDD:293786	3/28 (11%)
		Death_DAPK1	1330..1415	CDD:260052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810