DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and Phkg2

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_081164.2	Gene:	Phkg2 / 68961	MGIID:	1916211	Length:	406	Species:	Mus musculus

Alignment Length:	320	Identity:	96/320 - (30%)
Similarity:	162/320 - (50%)	Gaps:	37/320 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HKHYDVLGEVGRGKFGTVYKCRDKANG-------LQLAAKFVPIPKREDKRN-VEREVEIMNSLQ 87
            ::.||....:|||....|.:|..:|.|       ::::|:.:.:.:.|:.|: ..||:.|:..:.
Mouse    21 YQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQVA 85

  Fly    88 -HHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGI 151
             |..||.|..:||....|.:|.:|:..||||| .:.::..|:|:..|..:|.:.||::|:|.|.|
Mouse    86 GHPHIITLIDSYESSSFMFLVFDLMRKGELFD-YLTEKVALSEKETRSIMRSLLEAVSFLHANNI 149

  Fly   152 VHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCI------SY 210
            ||.||||||||:  ....:|::.|||.:...:..::||.|.|||.::|||::.  |.      .|
Mouse   150 VHRDLKPENILL--DDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILK--CSMDETHPGY 210

  Fly   211 G--TDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKD 273
            |  .|:|:.|||.:.|::|..||.....|..:..:...:|.|....::..|....|.|:|||..|
Mouse   211 GKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNTVKDLISKLLQVD 275

  Fly   274 LSTRMTAAECMKHKWLQQRPAT------------AATATPITKAASAASKSRLKSVSPVT 321
            ...|:||.:.::|.:.::...:            .|..|.:.....|.|..||:   |:|
Mouse   276 PEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTILAAGRVALSSHRLR---PLT 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	88/271 (32%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	86/265 (32%)
Phkg2	NP_081164.2	PKc_like	13..291	CDD:419665	88/274 (32%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		6/26 (23%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4277
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940