DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and STK33

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001275990.1	Gene:	STK33 / 65975	HGNCID:	14568	Length:	514	Species:	Homo sapiens

Alignment Length:	455	Identity:	128/455 - (28%)
Similarity:	209/455 - (45%)	Gaps:	76/455 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDK--RNVEREVEIMNSLQHHLIIQLYAAYEYQK 102
            :|:|.||.|.:..||....:.|.|.|...|....  :.:||||.|:.|::|..||.|...:|..|
Human   122 LGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPK 186

  Fly   103 MMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLKPENILV---L 164
            .|.:|:||.|.||| ..::|.:...:|...|..|:.:..|:|::|.|.|||.|||.|||:|   |
Human   187 KMYLVMELCEDGEL-KEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSL 250

  Fly   165 TQKGN----RIKIIDFGLA--RKFDPDKRLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVICYV 223
            ....|    .||:.|||||  ::...:..|:...|||.::||||::....|...|:||:||:.|:
Human   251 IDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYM 315

  Fly   224 LISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAK-DLSTRMTAAECMKHK 287
            |:.|..||:..::.:....:...:..||:..:|.|| :|...:.|.|.| |.:.|:||.|.:.::
Human   316 LLRGEPPFLASSEEKLFELIRKGELHFENAVWNSIS-DCAKSVLKQLMKVDPAHRITAKELLDNQ 379

  Fly   288 WLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSE--DSTETIEDEDDEEEVAVQQAKQ 350
            ||                    :.::|.||.|........|  ::.|::|:...||
Human   380 WL--------------------TGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEE--------- 415

  Fly   351 KDQQQDEELANLCGDAELENKELDATKDNLKNFIVRWETHPNSPYVFDVEGNVIAPLSETSYPHP 415
                                |...:|::.||:: ..|...|::.|..|.|....:...|..:|
Human   416 --------------------KNKPSTEEKLKSY-QPWGNVPDANYTSDEEEEKQSTAYEKQFP-- 457

  Fly   416 RRTHGADSLSSSRVCSPSPCDSISTLTDDERGDIEDLPEEDESRSAENESPRSVATPINESREKL 480
                 |.|..:..:|| |...|...|..:.:|::|..|......:|.....:|.|  ::.:::||
Human   458 -----ATSKDNFDMCS-SSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGA--LSRTKKKL 514

Fly 481 480
Human 515 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	91/260 (35%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	91/260 (35%)
STK33	NP_001275990.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..91
		STKc_STK33	114..381	CDD:270999	91/260 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..468		17/102 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..514		5/30 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810