DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sqa and CAMK1G

DIOPT Version :9

Sequence 1:NP_001260832.1 Gene:sqa / 36002 FlyBaseID:FBgn0259678 Length:888 Species:Drosophila melanogaster
Sequence 2:NP_065172.1 Gene:CAMK1G / 57172 HGNCID:14585 Length:476 Species:Homo sapiens


Alignment Length:506 Identity:134/506 - (26%)
Similarity:212/506 - (41%) Gaps:101/506 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKRNVEREVEIMNSLQHHL 90
            :..:..|.:..:..:|.|.|..|:..:.:..|...|.|.:.........::|.|:.::..::|..
Human    15 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHEN 79

  Fly    91 IIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLD 155
            |:.|...||......:|::|:.|||||||:: :..|.||:...:.|:||..|:.::|.|||||.|
Human    80 IVTLEDIYESTTHYYLVMQLVSGGELFDRIL-ERGVYTEKDASLVIQQVLSAVKYLHENGIVHRD 143

  Fly   156 LKPENILVLT-QKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGV 219
            |||||:|.|| ::.::|.|.||||: |.:.:..:....|||.:|||||:.....|...|.||:||
Human   144 LKPENLLYLTPEENSKIMITDFGLS-KMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGV 207

  Fly   220 ICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAECM 284
            |.|:|:.|..||..|.:.:....:....|:||...::.||....|||..||.||.:.|.|..:.:
Human   208 ITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKAL 272

  Fly   285 KHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIEDEDDEEEVAVQQ-- 347
            .|.|:....|......|              |||                        :.:|:  
Human   273 SHPWIDGNTALHRDIYP--------------SVS------------------------LQIQKNF 299

  Fly   348 AKQKDQQQDEELA----------NLCGDA---ELENK--ELDATKDNLKNFIVRWETHPNSPYVF 397
            ||.|.:|.....|          ||....   |:||:  |..|::          .:.|:||.:.
Human   300 AKSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASE----------TSRPSSPEIT 354

  Fly   398 DVEGNV------IAPLSETSYPHPRR------------THGADSLSSSRV------CSPSPCDSI 438
            ..|..|      :..|::....|.||            .:|:..:|||.|      .:..||...
Human   355 ITEAPVLDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCC 419

  Fly   439 ST-LTDDERGDIEDLPEEDESRSAENESPRSVATPINESREKLFPTVATSS 488
            |: |....:|......|....:.|..:.        |...|.:.|..|:.|
Human   420 SSCLNIGSKGKSSYCSEPTLLKKANKKQ--------NFKSEVMVPVKASGS 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sqaNP_001260832.1 S_TKc 34..289 CDD:214567 88/255 (35%)
STKc_MLCK 40..289 CDD:271005 88/249 (35%)
CAMK1GNP_065172.1 STKc_CaMKI_gamma 19..303 CDD:271068 98/323 (30%)
Autoinhibitory domain. /evidence=ECO:0000250 277..317 11/77 (14%)
Calmodulin-binding. /evidence=ECO:0000250 297..318 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..352 7/36 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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