DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and dapk1

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001093460.1	Gene:	dapk1 / 558314	ZFINID:	ZDB-GENE-060526-177	Length:	1439	Species:	Danio rerio

Alignment Length:	944	Identity:	223/944 - (23%)
Similarity:	362/944 - (38%)	Gaps:	240/944 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKR--------NVER 78
            :|:....:...:|::.||:|.|:|..|.|||.|:.|::.||||  |.||..|.        ::||
Zfish     1 MTVFNQENVEDYYEIGGELGSGQFAVVKKCRHKSTGVEYAAKF--IKKRRSKSSRRGVSKDDIER 63

  Fly    79 EVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAM 143
            ||.|:..:||..:|.|:..:|.:..:.::|||:.||||||.:.:.| .|:|.....|::|:.:.:
Zfish    64 EVSILKEIQHPNVITLHDVFENKHEVILILELVAGGELFDFLAEKE-SLSEEEATEFLKQILDGV 127

  Fly   144 AFIHGNGIVHLDLKPENILVLTQK--GNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFD 206
            :::|...|.|.|||||||::|.:.  ..|||:||||||.|.|.....:.:|||||||||||||::
Zfish   128 SYLHSKRISHFDLKPENIMLLNRNVPHPRIKLIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYE 192

  Fly   207 CISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLA 271
            .:....||||:|||.|:|:||.|||:|||..||::||:...|:|:::.|:..|....||||:||.
Zfish   193 PLGLEADMWSIGVITYILLSGASPFLGENKQETLANVSAVDYEFDEDYFSHTSALAKDFIARLLI 257

  Fly   272 KDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIED 336
            ||...|||..:.::|.|::.:.    |...:::..||.:..:.|..
Zfish   258 KDPKKRMTILDSLQHPWIKPKD----TQQALSRKESAVNMEKFKKF------------------- 299

  Fly   337 EDDEEEVAVQQAKQKDQQQDEELANLC--------GDAELENKELDATKDNLKNFIVRWETH--- 390
                       |.::..:|...|.:||        ..:.:.....|.|.|...:|:::...|
Zfish   300 -----------AARRKWKQSVRLISLCNRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAIN 353

  Fly   391 -PNSPYVFDVEGNVIAPLSETSYP--HPRRTHGADSLSSSRVCSPSPCDSISTLTDDERGDIE-- 450
             .|.|.:..:.|::      |||.  .|.: ||...|..:..|                |:::
Zfish   354 DDNVPGLKHLLGSL------TSYDINQPNK-HGTPPLLIAAGC----------------GNVQII 395

  Fly   451 --------DLPEEDESRSA------------------ENESPRSVATPINESREKLFPTVATSSP 489
                    ::...|::.::                  |.:.|..:.....|:...    ||....
Zfish   396 DVLMKKGAEIQAFDKTGASAIYYAARHGHVGTLRFLHEKKCPLDIQDKSGETALH----VAARYG 456

  Fly   490 STPTPQHL--FNENFDEFSGSQSTAQQQRSMKSY---LHTFDRRNSDTTYLLGRRSSGERVNLAD 549
            :....|:|  .:.|.|.....|.|.....:...|   .........|..   .|...||...|..
Zfish   457 NVDVVQYLCSIHANPDLLDREQETPLHCAAWHGYSAVARALCEAGCDVN---ARNREGESPLLTA 518

  Fly   550 EIRKLSDHLLMLAEINTKLGDANNNG--------------------------------------- 575
            ..|...|.:..|.|....:..|:.:|
Zfish   519 SARGFKDIVECLLEHGADMDSADKDGHIALHLAVRRCQVEVVKCLLSHHCYVDHQDRHGNTPLHI 583

  Fly   576 --SSSGAPADPPAAAAAAAAPVPT--STAPASVAPSGS----------TSSKTSEISQEGNRWTS 626
              ..:..|......||.|...:|.  ...|..:|.|..          :.:.|..|:.:|.....
Zfish   584 ACKDANMPVVTQLCAAKANLDIPNKFGRTPLHLAASNGGLEVVRHLCLSGANTEAITNDGKTAED 648

  Fly   627 KTTSSSSWNRPTLKGGLFSQASSSSQSQSTYDDGKGKTKISSLSVRLQQSIEETPKLS-NGNSSS 690
            ..|:....:...|...|......|...|               .:|..|:::...||. .|:|.:
Zfish   649 LATAEQQEHVAVLLAKLKKDNHKSIYIQ---------------QLRPTQTLQHRLKLKLFGHSGA 698

  Fly   691 SKSLVQSQRKSTVQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSSNYIASNASN--SI 753
            .||       :.|:::.....|||..::                |:..|:...:.||..::  ::
Zfish   699 GKS-------TLVESLKCGILRSFFRRR----------------RTRLTNPVRHPASPVTSKPAV 740

  Fly   754 STSASNPSSTGASNPITTSASNESASSRRAKFRINQMSRDVPVGLPDTHQTVNLEEAANTTKDCL 818
            |.|.||         :.....|.|..||...|..:.....:.|..|       :..|.:|..|..
Zfish   741 SVSISN---------LYPGCENVSVRSRSMMFEPSLTKGVLEVFSP-------VHNALSTADDTA 789

  Fly   819 LHLLEKYNETRIRNPVGRHQSISVDWRVSDNLEY 852
            ...::..|..  .|.||   ..|: |..|.|..|
Zfish   790 TKAIDIQNAN--VNGVG---DFSI-WEFSGNPVY 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	116/264 (44%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	113/258 (44%)
dapk1	NP_001093460.1	STKc_DAPK1	7..275	CDD:271096	116/270 (43%)
		S_TKc	13..275	CDD:214567	116/264 (44%)
		Ank_2	<337..409	CDD:289560	15/94 (16%)
		ANK	373..497	CDD:238125	19/144 (13%)
		ANK repeat	378..409	CDD:293786	5/46 (11%)
		Ank_4	379..432	CDD:290365	5/68 (7%)
		ANK repeat	412..442	CDD:293786	2/29 (7%)
		Ank_2	416..508	CDD:289560	13/98 (13%)
		ANK	439..564	CDD:238125	21/131 (16%)
		ANK repeat	444..475	CDD:293786	7/34 (21%)
		ANK repeat	477..508	CDD:293786	4/33 (12%)
		ANK	505..629	CDD:238125	18/126 (14%)
		ANK repeat	510..541	CDD:293786	7/30 (23%)
		Ank_4	513..564	CDD:290365	7/50 (14%)
		ANK repeat	543..574	CDD:293786	1/30 (3%)
		Ank_2	548..635	CDD:289560	8/86 (9%)
		ANK repeat	576..607	CDD:293786	4/30 (13%)
		ANK	604..>671	CDD:238125	10/66 (15%)
		ANK repeat	609..638	CDD:293786	4/28 (14%)
		Ank_4	610..662	CDD:290365	7/51 (14%)
		Death_DAPK1	1310..1399	CDD:260052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810