DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and mylkb

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	XP_009300538.1	Gene:	mylkb / 492576	ZFINID:	ZDB-GENE-041111-150	Length:	966	Species:	Danio rerio

Alignment Length:	490	Identity:	180/490 - (36%)
Similarity:	265/490 - (54%)	Gaps:	64/490 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDSEPEGVLEPAFPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPK 69
            ||.|.:   ||.:  |||.|.::......||:...:|.||||.|:|..:|::....|.||:....
Zfish   503 DDDEEK---EPEY--RDVVIKKDCSVKDFYDIEDRLGTGKFGQVFKLVEKSSKKVWAGKFIKAFS 562

  Fly    70 REDKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRV 134
            :::|.||.:|:.|||||.|..::|...|:|.:..|.:|:|:|.|||||:|:||::|.||||....
Zfish   563 QKEKENVRQEIGIMNSLHHPKLVQCMDAFEGKSDMVMVMEMISGGELFERIVDEDFELTEREVIK 627

  Fly   135 FIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVA 199
            ::.|:.:.:.|||..||||||||||||:.:.:.|::||:|||||||:.:....|:||||||||||
Zfish   628 YMLQIIDGVQFIHKQGIVHLDLKPENIMCINKTGSKIKLIDFGLARRLEDSGSLKVLFGTPEFVA 692

  Fly   200 PEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLD 264
            |||:|::.|||.|||||:|||||:|:||||||||:||.||::|||.|.:|||||.|:.||.:..|
Zfish   693 PEVINYEAISYPTDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFEDEAFDEISDQAKD 757

  Fly   265 FIAKLLAKDLSTRMTAAECMKHKWLQQ--------------------RPATAATATPITKAASAA 309
            ||::||.||:..|:|.|:|.:|.||:|                    |.....|...:...:..:
Zfish   758 FISRLLKKDMRARLTCAQCFEHSWLKQDTKNMEAKQLSKERMKKYILRRRWQKTGNAVRAISRFS 822

  Fly   310 SKSRLKSVSPVTAPSESSEDSTETIEDEDDEEEVAVQQAKQKDQQQDEELANLCGDAELENKELD 374
            |...|..:.|..:.....|.....:|..:||.......:          .|::..|.|:
Zfish   823 SMGMLGGIGPKKSSPTEEEPPAPFLESVEDENHTPAAPS----------FASVIQDVEV------ 871

  Fly   375 ATKDNLKNFIVRWETHPNSPYVFDVEGNVIAPLSET-SYPHPRRTHGADSLSSSRVC----SPSP 434
             .:.:...|..:.|..|:...|:..:..   |:.|| .:.......|..||..|.||    :...
Zfish   872 -VEGSAARFDCKIEGCPDPEVVWYKDDQ---PIKETRHFQIDYEEDGHCSLVISEVCPDDDAKYT 932

  Fly   435 CDSISTLTD-------------DERGDIEDLPEED 456
            |.:::.|.:             :|.||.|. .|||
Zfish   933 CKAVNGLGEASCTAELMVEFMQEEEGDAEG-EEED 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	134/254 (53%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	132/248 (53%)
mylkb	XP_009300538.1	I-set	166..255	CDD:254352
		IGc2	180..245	CDD:197706
		Ig	296..394	CDD:299845
		I-set	296..386	CDD:254352
		FN3	390..475	CDD:238020
		PKc_like	524..782	CDD:304357	134/257 (52%)
		Pkinase	527..782	CDD:278497	134/254 (53%)
		I-set	860..950	CDD:254352	18/109 (17%)
		IGc2	873..940	CDD:197706	14/69 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1471
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910