DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and nek2

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	XP_012823629.1	Gene:	nek2 / 407849	XenbaseID:	XB-GENE-962774	Length:	425	Species:	Xenopus tropicalis

Alignment Length:	394	Identity:	140/394 - (35%)
Similarity:	209/394 - (53%)	Gaps:	60/394 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EPAFPMRDVTINRNVDAHKH------YDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKRE- 71
            |....:.|...|.|:.:.||      |::|.::|.|.||.|.||::|:.|...|.||:...|.:
Frog    31 EDIIHLEDEVFNPNMTSFKHENVEDLYELLEKLGSGHFGEVKKCKEKSTGTYYAGKFIKTRKCKG 95

  Fly    72 -----DKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERV 131
                 |:..|||||.|:..|:|..|::|:..:..:..|.::||||.||||||.:.:.| .|:|..
Frog    96 SRLGLDRDQVEREVFILQQLEHPNIMRLHDVFASKAEMVLILELIRGGELFDFIAEKE-ALSEED 159

  Fly   132 CRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKG---NRIKIIDFGLARKFDPDKRLRVLFG 193
            ...|:.|:.:.:|::|...|.|.|||||||::| ||.   .:|||||||||:|.:.....:.|.|
Frog   160 AIEFLEQILKGVAYMHTRSIAHFDLKPENIMLL-QKDVPHPKIKIIDFGLAQKIEDGTVFKSLCG 223

  Fly   194 TPEFVAPEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGI 258
            ||:::||||:|::.:...|||||:|||.|:|:||||||.||.|.||::||....|:|:|..|...
Frog   224 TPQYIAPEVINYEPLGPPTDMWSIGVITYILLSGLSPFQGETDQETLTNVVAGSYEFDDRIFKQT 288

  Fly   259 SPECLDFIAKLLAKDLSTRMTAAECMKHKW---LQQRPATAATATPIT----KAASAASKSR--- 313
            |....|||.:||.||...||||.||:.|.|   |.::.|...:.:.|.    |..:|..|.:
Frog   289 SELAKDFIRQLLLKDPRDRMTAVECLIHPWIKPLNRKQAVNRSRSSINMKNFKKFNARRKWKLSY 353

  Fly   314 -------------------------------LKSVSPVTAPSESSEDSTETIEDEDDEEEVAVQQ 347
                                           |:..||:|..|..:....|:  |::||:...|..
Frog   354 NMVSACNRLCRMKLLCNPMKDEEELFYSGDLLRPTSPLTERSNKTRRQCES--DQEDEKTKPVTL 416

  Fly   348 AKQK 351
            .:::
Frog   417 LRRR 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	118/266 (44%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	116/260 (45%)
nek2	XP_012823629.1	STKc_DAPK	51..319	CDD:271007	117/269 (43%)
nek2	XP_012823629.1	S_TKc	57..319	CDD:214567	117/263 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000818
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000