DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and Obscn

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001164983.2	Gene:	Obscn / 380698	MGIID:	2681862	Length:	8032	Species:	Mus musculus

Alignment Length:	787	Identity:	190/787 - (24%)
Similarity:	323/787 - (41%)	Gaps:	154/787 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKRNVEREVEIMNSLQHHLIIQLY 95
            |..|||..|:|||.||.|.:.:.|.|.:..||||:|: :.:.:....:|.:|:.:|.|.|:..|.
Mouse  6559 HSFYDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPL-RSKTRAQAYQERDILATLGHPLVTGLL 6622

  Fly    96 AAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLKPEN 160
            ..:|.:|.:.::|||....||.||:. .:.|:||...:|:|:|:.|.:.::|.:||:|||:||.|
Mouse  6623 DQFETRKTLILILELCSSEELLDRLF-KKGVVTEAEVKVYIQQLVEGLHYLHSHGILHLDIKPPN 6686

  Fly   161 ILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVICYVLI 225
            ||::......|||.|||.|:|..|.:.....:|:||||:||::..:.:|.|:|:|::|||.|:.:
Mouse  6687 ILMVHPAREDIKICDFGFAQKITPSEPQYSKYGSPEFVSPEIIEQNPVSEGSDIWAMGVISYLSL 6751

  Fly   226 SGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAECMKHKW-L 289
            :..|||.||:|..|:.||...:..:.......:|.:..|||...|.:....|.:.::|:.|.| |
Mouse  6752 TCSSPFAGESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQRTPRARPSTSQCLAHPWFL 6816

  Fly   290 QQRPATAATATPITKAASAASKSR----LKSVSPVTAPSESSEDSTETIEDEDDEEEVAVQQAKQ 350
            :..||..|......:.....::||    |.|...:..    .....|.::...|...:.|.:
Mouse  6817 KSMPAEEAHFINTKQLKFLLARSRWQRSLMSYKSILV----MRSIPELLQGPPDSPSLGVAR--- 6874

  Fly   351 KDQQQDEELANLCGDAELENKELDATKDNLKNFIVRWETHPNSPYVFDVEGNVIAPLSETSYPHP 415
                      :|.|:|...:....::.:.|..| .|.::.|.||...       :||.     ||
Mouse  6875 ----------HLRGEASGASSSSSSSDNELAPF-ARAKSLPPSPVTH-------SPLL-----HP 6916

  Fly   416 RRTHGADSLSSSRVCSPSPCDSISTLTDDERGDIEDLPEEDESR-----SAENESPRSVATPINE 475
            |           ....||                ..||||.|:.     :|...||:|...|
Mouse  6917 R-----------GFLRPS----------------ASLPEETEASMPTADAAVPASPQSAGPP--- 6951

  Fly   476 SREKLFPTVATSSPSTPTPQH-----LFNENFDEFS--GSQSTAQQQRSMKSYLHTFDRRNSDTT 533
                       :||.. .|:|     ||.:...|.:  |::::..::       |...||:....
Mouse  6952 -----------ASPGC-VPRHSVISSLFYQQAGEGAERGNKTSGAKR-------HPARRRHLLKG 6997

  Fly   534 YLLGRRSSGER-----VNLADEIRKLSDHLLMLAEINTKLGDANNNGSSSGAPADPPAAAAAAAA 593
            ..:.|...|.|     .:|.:|.....:...::.:  |...:......||.....|..:.:....
Mouse  6998 GYIARALPGLREPLMEYSLLEEEAAREEQASLMTK--TPSFETALRLPSSSVREVPGRSHSLDNP 7060

  Fly   594 PVPTSTAPASVAPSGSTSSKTSEISQEGNRWTSKTTSSSSWNR----------PTLKGGLFSQAS 648
            ||.|..:|        .:.|...:.......|.:||:....::          |.:.|    .:.
Mouse  7061 PVTTGPSP--------EACKEQLLFPPSTGLTHETTAKDRGHKEGFLQESVPFPPMSG----DSR 7113

  Fly   649 SSSQSQSTYDDGKGKTKISSLSVRLQQSIEETPKLSNGNSS-----SSKSLVQSQRKSTVQTMSS 708
            ...|..|:.|..:||...|..|           :|.:|:..     ||:||.....:|..:.:|:
Mouse  7114 PGKQEGSSQDSCRGKPASSCHS-----------ELGSGSQEGCGPPSSQSLGSLPPQSLKKELST 7167

  Fly   709 SNARSFTNQ-QVQRTSTTSSKVISSSTRSSNTSSSNYIASNASNSISTSASNPSSTGASNPITTS 772
            |....|:.| |.....|..|.::.|.....:.|.|       ...:...:|:|   |:::.:..|
Mouse  7168 SCGPLFSEQPQAAPFPTQVSPLLGSEKEPQDGSLS-------EGPVPVPSSSP---GSASQVDAS 7222

  Fly   773 ASNESAS 779
            ...|..|
Mouse  7223 LDTEGLS 7229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	92/255 (36%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	88/249 (35%)
Obscn	NP_001164983.2	I-set	3855..3938	CDD:254352
		IGc2	3868..3926	CDD:197706
		I-set	3943..4026	CDD:254352
		Ig_2	3951..4021	CDD:290606
		I-set	4031..4114	CDD:254352
		IGc2	4044..4102	CDD:197706
		I-set	4119..4202	CDD:254352
		I-set	4208..4291	CDD:254352
		ig	4211..4279	CDD:278476
		I-set	4297..4380	CDD:254352
		Ig	4313..4381	CDD:143165
		I-set	4385..4471	CDD:254352
		Ig	4399..4464	CDD:299845
		I-set	4478..4563	CDD:254352
		Ig	4490..4547	CDD:299845
		I-set	4566..4654	CDD:254352
		I-set	4660..4745	CDD:254352
		FN3	4749..4834	CDD:238020
		I-set	4862..4923	CDD:254352
		I-set	5127..5217	CDD:254352
		Ig	5144..5213	CDD:143165
		I-set	5357..5447	CDD:254352
		Ig	5375..5444	CDD:143165
		I-set	5489..5579	CDD:254352
		Ig	5513..5579	CDD:299845
		Ig	5599..5695	CDD:299845
		I-set	5600..5695	CDD:254352
		SH3_Obscurin_like	5831..5893	CDD:212958
		RhoGEF	5926..6102	CDD:295373
		PH_Obscurin	6111..6235	CDD:270059
		I-set	6243..6335	CDD:254352
		Ig	8..90	CDD:299845
		I-set	9..98	CDD:254352
		I-set	109..200	CDD:254352
		Ig	126..190	CDD:143165
		IG	246..326	CDD:214652
		Ig	250..319	CDD:299845
		I-set	333..416	CDD:254352
		I-set	423..499	CDD:254352
		FN3	513..600	CDD:238020
		I-set	615..>671	CDD:254352
		IGc2	<732..781	CDD:197706
		IGc2	878..941	CDD:197706
		IGc2	970..1033	CDD:197706
		IGc2	1062..1125	CDD:197706
		IGc2	1154..1217	CDD:197706
		IGc2	1246..1309	CDD:197706
		IGc2	1338..1401	CDD:197706
		IGc2	1430..1493	CDD:197706
		IGc2	1522..1585	CDD:197706
		IGc2	1614..1677	CDD:197706
		IGc2	1706..1769	CDD:197706
		IGc2	1798..1861	CDD:197706
		IGc2	1891..1950	CDD:197706
		I-set	1967..2050	CDD:254352
		Ig	1983..2051	CDD:143165
		I-set	2057..2140	CDD:254352
		IGc2	2069..2132	CDD:197706
		I-set	2147..2229	CDD:254352
		I-set	2324..2406	CDD:254352
		Ig	2331..2395	CDD:299845
		I-set	2449..2530	CDD:254352
		Ig	2464..2531	CDD:143165
		I-set	2626..2709	CDD:254352
Ig	2642..2710	CDD:143165
I-set	2716..2798	CDD:254352
I-set	2804..2887	CDD:254352
Ig	2820..2888	CDD:143165
I-set	2894..>2962	CDD:254352
I-set	2985..3065	CDD:254352
Ig_2	2989..3060	CDD:290606
I-set	3073..3156	CDD:254352
IG	3168..3247	CDD:214652
I-set	3254..3336	CDD:254352
Ig_2	3258..3337	CDD:290606
I-set	3342..3425	CDD:254352
ig	3346..3412	CDD:278476
I-set	3431..3513	CDD:254352
IGc2	3443..3501	CDD:197706
I-set	3519..3601	CDD:254352
IGc2	3531..3589	CDD:197706
I-set	3612..3689	CDD:254352
IGc2	3619..3677	CDD:197706
I-set	3695..>3763	CDD:254352
I-set	3768..3850	CDD:254352
IGc2	3780..3838	CDD:197706
Ig	6260..6327	CDD:143165
IG_like	6349..6427	CDD:214653
IGc2	6350..6418	CDD:197706
I-set	6452..6541	CDD:254352
Ig	6475..6538	CDD:143165
PKc_like	6559..6815	CDD:304357	92/257 (36%)
S_TKc	6562..6815	CDD:214567	91/254 (36%)
IGc2	7540..7606	CDD:197706
FN3	7620..7698	CDD:214495
PKc_like	7732..7988	CDD:304357
S_TKc	7741..7984	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810