DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and Dapk1

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	XP_008769663.1	Gene:	Dapk1 / 306722	RGDID:	1311629	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	980	Identity:	255/980 - (26%)
Similarity:	387/980 - (39%)	Gaps:	254/980 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDK--------RNVER 78
            :|:.|..:...:||...|:|.|:|..|.|||:|:.|||.||||  |.||..|        .::||
  Rat     1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKF--IKKRRTKSSRRGVSREDIER 63

  Fly    79 EVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAM 143
            ||.|:..::|..:|.|:..||.:..:.::|||:.||||||.:.:.| .|||.....|::|:...:
  Rat    64 EVSILKEIRHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEFLKQILSGV 127

  Fly   144 AFIHGNGIVHLDLKPENILVLTQK--GNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFD 206
            .::|...|.|.|||||||::|.:.  ..||||||||||.|.|.....:.:||||||||||:||::
  Rat   128 YYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYE 192

  Fly   207 CISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLA 271
            .:....||||:|||.|:|:||.|||:|:...||::||:...||||:|.|...|....|||.:||.
  Rat   193 PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLV 257

  Fly   272 KDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIED 336
            ||...|||..:.::|.|::.:.    |...:::.|||.:..:.|..
  Rat   258 KDPKKRMTIQDSLQHPWIKPKD----TQQALSRKASAVNMEKFKKF------------------- 299

  Fly   337 EDDEEEVAVQQAKQKDQQQDEELANLC--------GDAELENKELDATKDNLKNFIVRWETHPNS 393
                       |.:|..:|...|.:||        ..:.:.....|.|.|...:|:::...|..:
  Rat   300 -----------AARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAIN 353

  Fly   394 PYVFDVEGNVIAPLSETSYPHPRRTHGADSLSSSRVCSPSP-----------CDSISTL-TDDER 446
                  :.||           |...|...||||..|..|:.           |.:|..| ...:|
  Rat   354 ------DDNV-----------PGLQHLLGSLSSYDVNQPNKHGTPPLLIAAGCGNIQMLQLLIKR 401

  Fly   447 GDIEDLPEEDESRSA----------------ENESPRSVATPINESREKLFPTVA---------- 485
            |...|:.::..|.:.                ||:.|..|.   ::|.|......|
  Rat   402 GSRIDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVK---DKSGETALHVAARYGHADVVQL 463

  Fly   486 -TSSPSTP--------TPQHLFNENFDEFSGSQSTAQ-----------QQRSMKSYLHTFDRRN- 529
             .|..|.|        ||.|.     ..:.|..|.|:           :.|..::.|.|...|.
  Rat   464 LCSFGSNPDFQDKEEETPLHC-----AAWHGYYSVARALCEVGCNVNIKNREGETPLLTASARGY 523

  Fly   530 SDTTYLLGRRSSGERVNLADEIRKLSDHLLM----LAEINTKLG--------DANNNGSSSGAPA 582
            .|....|...  |..:|.:|:...::.||.:    :..|.|.||        |.:.|.....|..
  Rat   524 HDIVECLAEH--GADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGCLVDFQDRHGNTPLHVACK 586

  Fly   583 DPPAAAAAAAAPVPTSTAPASVAPSGSTSSKTSEISQEGNRWTSKTTSSSSWNRPTLKGGLFSQA 647
            |       .:||:..:...||.         ..:||.:..|    |....:.|...|....:...
  Rat   587 D-------GSAPIVVALCEASC---------NLDISNKYGR----TPLHLAANNGILDVVRYLCL 631

  Fly   648 SSSSQSQSTYDDGKGKT-----------KISSLSVRLQ---------QSIEETPKLSN------- 685
            ..::....|.|   |||           .::.|..||:         |.:..|..|..
  Rat   632 MGANVEALTLD---GKTAEDLAKAEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLF 693

  Fly   686 GNSSSSKSLVQSQRKSTVQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSSNYIASNAS 750
            |:|.|.||       :.|:::.....|||..::..|.|:|      :|||...
  Rat   694 GHSGSGKS-------TLVESLKCGLLRSFFRRRRPRLSST------NSTRFPP------------ 733

  Fly   751 NSISTSASNPSSTGASNPITTSASNESASSRRAKFR--INQMSRDVPVGLPDTHQTVNLEEAANT 813
               |..|:.|:.:.:.|.:.....|.|..||...|.  :.:...:|.|. |..|...:.::.:..
  Rat   734 ---SPLATKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVA-PSHHLHCSTDDQSTK 794

  Fly   814 TKDCLLHLLEKYNETRIRNPVGRHQSISVDWRVSDNLEYRSMSSINAFFQRHNPNGGGHNVRHIQ 878
            ..|.         :....|.||   ..|| |..|.|..|.....   :|..::|.    ::..|.
  Rat   795 AIDI---------QNAYLNGVG---DFSV-WEFSGNPVYFCCYD---YFAANDPT----SIHIIV 839

  Fly   879 AQLEE 883
            ..|||
  Rat   840 FSLEE 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	119/264 (45%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	116/258 (45%)
Dapk1	XP_008769663.1	STKc_DAPK1	7..275	CDD:271096	119/270 (44%)
		S_TKc	13..275	CDD:214567	119/264 (45%)
		Ank_2	<337..409	CDD:289560	19/88 (22%)
		ANK	373..497	CDD:238125	24/131 (18%)
		ANK repeat	378..409	CDD:293786	6/30 (20%)
		Ank_2	383..475	CDD:289560	17/94 (18%)
		ANK repeat	412..442	CDD:293786	5/32 (16%)
		ANK	439..564	CDD:238125	26/134 (19%)
		ANK repeat	444..475	CDD:293786	6/30 (20%)
		Ank_2	449..541	CDD:289560	18/98 (18%)
		ANK repeat	477..508	CDD:293786	6/35 (17%)
		ANK	505..629	CDD:238125	29/145 (20%)
		ANK repeat	510..541	CDD:293786	7/32 (22%)
		ANK repeat	543..574	CDD:293786	6/30 (20%)
		Ank_2	548..638	CDD:289560	20/109 (18%)
		ANK repeat	576..607	CDD:293786	8/46 (17%)
		ANK repeat	609..638	CDD:293786	4/32 (13%)
		Death_DAPK1	1308..1393	CDD:260052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810