DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and Camk1d

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_796317.2	Gene:	Camk1d / 227541	MGIID:	2442190	Length:	385	Species:	Mus musculus

Alignment Length:	339	Identity:	111/339 - (32%)
Similarity:	171/339 - (50%)	Gaps:	25/339 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKR-NVEREVEIMNSLQHHLII 92
            |..|.::....:|.|.|..|....:||.|...|.|.:|....:.|. ::|.|:.::..::|..|:
Mouse    18 DIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82

  Fly    93 QLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLK 157
            .|...||....:.:|::|:.|||||||:|:..| .||:.....||||.:|:.::|..||||.|||
Mouse    83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGF-YTEKDASTLIRQVLDAVYYLHRMGIVHRDLK 146

  Fly   158 PENILVLTQ-KGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVIC 221
            |||:|..:| :.::|.|.||||::.......:....|||.:|||||:.....|...|.||:|||.
Mouse   147 PENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIA 211

  Fly   222 YVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAECMKH 286
            |:|:.|..||..|||.:....:..|:|:|:...::.||....|||..|:.||.:.|.|..:..:|
Mouse   212 YILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARH 276

  Fly   287 KWLQQRPATAATATPITKAASAA-----SKSRLKSVSPVTAPSE--------SSEDSTETIEDED 338
            .|:   ....|.:..|.::.||.     :||:.:.....||...        ||.||:......:
Mouse   277 PWI---AGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSLDSSNASVSSN 338

  Fly   339 DEEEVAVQQAKQKD 352
                  :..|.|||
Mouse   339 ------LSLASQKD 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	92/256 (36%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	92/250 (37%)
Camk1d	NP_796317.2	STKc_CaMKI_delta	12..312	CDD:271070	101/297 (34%)
		Autoinhibitory domain. /evidence=ECO:0000250	279..319		8/42 (19%)
		Calmodulin-binding. /evidence=ECO:0000250	299..320		4/20 (20%)
		Nuclear export signal. /evidence=ECO:0000250	318..324		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810