DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sqa and Trio

DIOPT Version :9

Sequence 1:NP_001260832.1 Gene:sqa / 36002 FlyBaseID:FBgn0259678 Length:888 Species:Drosophila melanogaster
Sequence 2:NP_001074771.1 Gene:Trio / 223435 MGIID:1927230 Length:3103 Species:Mus musculus


Alignment Length:308 Identity:112/308 - (36%)
Similarity:161/308 - (52%) Gaps:16/308 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 VLEPAFPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFV--PIPKREDKR 74
            ||.|......||...|.||  .|..:.|:|||:|..|.||..|.....:|.|||  .:.||:   
Mouse  2780 VLGPGSDGIVVTWKDNFDA--FYSEVAELGRGRFAVVKKCDQKGTKRAVATKFVNKKLMKRD--- 2839

  Fly    75 NVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQV 139
            .|..|:.|:.:|||.|::.|...:|......:|||:.:.|.|.|.|| ....|||...|..:.:|
Mouse  2840 QVTHELGILQNLQHPLLVSLLDTFETPTSYVLVLEMADQGRLLDCVV-RWGSLTEGKVRAHLGEV 2903

  Fly   140 CEAMAFIHGNGIVHLDLKPENILVLTQKGN-RIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVV 203
            .||:.::|...|.|||||||||||...... .||:.|||.|.:.:....:..|.|.|||.|||::
Mouse  2904 LEAVRYLHNCRIAHLDLKPENILVDQSLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEII 2968

  Fly   204 NFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAK 268
            ..:.:|...|.|||||:.|||:||:|||:.::..||..|:....:.|.::.|.|:|.:..:|:..
Mouse  2969 LGNPVSLTADTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPEDYFQGVSQKAKEFVCF 3033

  Fly   269 LLAKDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKS 316
            ||.:|.:.|.:||..::.:|||....:.       |.......|||.|
Mouse  3034 LLQEDPAKRPSAALALQEQWLQAGNGSG-------KGTGVLDTSRLTS 3074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sqaNP_001260832.1 S_TKc 34..289 CDD:214567 96/257 (37%)
STKc_MLCK 40..289 CDD:271005 94/251 (37%)
TrioNP_001074771.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
SEC14 69..204 CDD:214706
Spectrin 1 218..338
SPEC 220..445 CDD:238103
Spectrin 2 340..446
SPEC 341..566 CDD:238103
Spectrin 3 566..672
SPEC 567..783 CDD:238103
Spectrin 4 673..784
SPEC 787..1014 CDD:238103
Spectrin 5 907..1012
SPEC 908..1137 CDD:238103
Spectrin 6 1138..1244
SPEC 1143..1243 CDD:197544
RhoGEF 1295..1465 CDD:238091
PH1_Kalirin_Trio_like 1472..1594 CDD:270060
PH 1505..1590 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1651
SH3_Kalirin_1 1659..1718 CDD:212786
SH3-RhoG_link 1715..1972 CDD:293215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1781..1906
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1927..1957
RhoGEF 1970..2143 CDD:238091
PH2_Kalirin_Trio_p63RhoGEF 2148..2286 CDD:270061
PH 2175..2271 CDD:278594
SH3_Kalirin_2 2559..2617 CDD:212787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2643..2666
I-set 2689..2780 CDD:254352 112/308 (36%)
Ig 2703..2780 CDD:299845 112/308 (36%)
STKc_Trio_C 2792..3054 CDD:271015 99/267 (37%)
S_TKc 2800..3054 CDD:214567 96/257 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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