DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and Snrk

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001158044.1	Gene:	Snrk / 20623	MGIID:	108104	Length:	748	Species:	Mus musculus

Alignment Length:	839	Identity:	194/839 - (23%)
Similarity:	321/839 - (38%)	Gaps:	194/839 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKRNVE--------REVEIMNSLQHHL 90
            ||:...:|||.|..|...|....|.::|.|.:      ||..::        :||..|..:||..
Mouse    16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVI------DKTKLDTLATGHLFQEVRCMKLVQHPN 74

  Fly    91 IIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLD 155
            |::||...:.|..:.::|||.:||::||.::..|..|.|.:.:.:..|:..|:::.|...:||.|
Mouse    75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRD 139

  Fly   156 LKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVV---NFDCISYGTDMWSV 217
            |||||: |..:|...:|:.|||.:.||.|.|:|....|:..:.|||::   .:|  :...|:||:
Mouse   140 LKPENV-VFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD--APAVDIWSL 201

  Fly   218 GVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAE 282
            |||.::|:.|..||...||.||::.:...||.....    :|..|.|.|.::|.:|...|.:..|
Mouse   202 GVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPPR----VSAGCRDLITRMLQRDPKRRASLEE 262

  Fly   283 CMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIEDE----DDEEEV 343
            ...|.|||....:.||...|                |:.:....||:...:|...    |..:..
Mouse   263 IESHPWLQGVDPSPATKYNI----------------PLVSYKNLSEEEHNSIIQRMVLGDIADRD 311

  Fly   344 AVQQAKQKDQQQD---------EELANLCGDAELENKEL---DATKDNLK-NFIVRWETHPNSPY 395
            |:.:|.:.::...         |.:..     |.:.||:   .|:..|:| .|...|.|..:.|.
Mouse   312 AIVEALETNRYNHITATYFLLAERILR-----EKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQ 371

  Fly   396 VFDVEGNVIA-PLSETSYPHPRRTHGADSLSSSR---VCSPSPCDSISTLTDDERGDIEDLP--- 453
              |:|.::.| |||..:.|......|.:.|:..|   :|.|:..|.:..|....   :..:|
Mouse   372 --DLEDDLTATPLSHATVPQSPARAGDNVLNGHRSKGLCDPAKKDELPELAGPA---LSTVPPAS 431

  Fly   454 --------------EEDESRSAENESPRSVATPINESREKLFPTVATSSPSTPTPQHLF--NENF 502
                          ||||....|::.|.|::|.:...|:.......||..|.|....:|  .|:.
Mouse   432 MKPAASGRKCLFRVEEDEEEDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESD 496

  Fly   503 DEFSGSQSTAQQQRSMKSYLHT-------FDRRNSDTTYLLGRRSSGERVNLADE-------IRK 553
            |||...::...:...:|..:.:       :.||.|.     ||.||......:|:       :.|
Mouse   497 DEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQ-----GRGSSCSSSETSDDDSESRRRLDK 556

  Fly   554 LSDHLLMLAEINTKLGDANNNGSSSGAPADPPAAAAAAAAPVPTSTAPASVAPSGSTSSKTSEIS 618
            .|.........::..|...:.|...|............|:|....|...|...||.|.|.|:..|
Mouse   557 DSGFAYSWHRRDSSEGPPGSEGDGGGQSKPSSGGGVDKASPGEQGTGGGSQGGSGGTPSGTAGSS 621

  Fly   619 QEGNRWTSKTTSSSSWNRPTLKGGLFSQASSSSQSQSTYDDGKGKTKISSLSVRLQQSIEETPKL 683
            :   |.....:||.            |.||:|:..:               ...|.||::.....
Mouse   622 R---RCAGPDSSSP------------SPASASAAPR---------------GAELVQSLKLVSLC 656

  Fly   684 SNGNSSSSKSLVQSQRKSTVQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSSNYIASN 748
            .......:|.::..|:            ..|::.:||..||.
Mouse   657 LGSQLHGAKYILDPQK------------ALFSSVKVQEKSTW----------------------- 686

  Fly   749 ASNSISTSASNPSSTGASNPITTSASNESASSRRAKFRINQMSRDVPVGLPDTHQTVNL 807
               .:..||..||.:...:|:.|.           |.|.|.:.      ||...:|:::
Mouse   687 ---KMCISAPGPSPSADLDPVRTK-----------KLRNNALQ------LPLCEKTISV 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	84/265 (32%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	82/259 (32%)
Snrk	NP_001158044.1	STKc_SNRK	12..269	CDD:270976	84/265 (32%)
		UBA_SNRK	288..335	CDD:270524	6/46 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..415		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..640		35/168 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000