DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and DAPK1

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001275658.1	Gene:	DAPK1 / 1612	HGNCID:	2674	Length:	1430	Species:	Homo sapiens

Alignment Length:	893	Identity:	230/893 - (25%)
Similarity:	353/893 - (39%)	Gaps:	223/893 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDK--------RNVER 78
            :|:.|..:...:||...|:|.|:|..|.|||:|:.|||.||||  |.||..|        .::||
Human     1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKF--IKKRRTKSSRRGVSREDIER 63

  Fly    79 EVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAM 143
            ||.|:..:||..:|.|:..||.:..:.::|||:.||||||.:.:.| .|||.....|::|:...:
Human    64 EVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEFLKQILNGV 127

  Fly   144 AFIHGNGIVHLDLKPENILVLTQK--GNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFD 206
            .::|...|.|.|||||||::|.:.  ..||||||||||.|.|.....:.:||||||||||:||::
Human   128 YYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYE 192

  Fly   207 CISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLA 271
            .:....||||:|||.|:|:||.|||:|:...||::||:...|:||||.|:..|....|||.:||.
Human   193 PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLV 257

  Fly   272 KDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIED 336
            ||...|||..:.::|.|::.:.    |...:::.|||.:..:.|..
Human   258 KDPKKRMTIQDSLQHPWIKPKD----TQQALSRKASAVNMEKFKKF------------------- 299

  Fly   337 EDDEEEVAVQQAKQKDQQQDEELANLC--------GDAELENKELDATKDNLKNFIVRWETHP-N 392
                       |.:|..:|...|.:||        ..:.:.....|.|.|...:|:::...|. |
Human   300 -----------AARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAIN 353

  Fly   393 SPYVFDVEGNVIAPLSETSYPHPRRTHGADSLSSSRVCSPSPCDSISTL-TDDERGDIEDLPEED 456
            ...|..:: :::..||......|.: ||...|..:     :.|.:|..| ...:||...|:.::.
Human   354 DDNVPGLQ-HLLGSLSNYDVNQPNK-HGTPPLLIA-----AGCGNIQILQLLIKRGSRIDVQDKG 411

  Fly   457 ESRS----------------AENESPRSVATPINESREKLFPTVAT--------------SSPS- 490
            .|.:                :||:.|..|.   ::|.|......|.              |:|:
Human   412 GSNAVYWAARHGHVDTLKFLSENKCPLDVK---DKSGEMALHVAARYGHADVAQLLCSFGSNPNI 473

  Fly   491 ----TPTPQHL-----------------FNENFDEFSGSQSTAQQQRSMKSY------------- 521
                ..||.|.                 .|.|.....|  .|.....|.:.|
Human   474 QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG--ETPLLTASARGYHDIVECLAEHGAD 536

  Fly   522 LHTFDRRNSDTTYLLGRR----------SSGERVNLADEIRKLSDH----------LLMLAEINT 566
            |:..|:......:|..||          |.|..|:..|.......|          ::.|.|.|.
Human   537 LNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANC 601

  Fly   567 KLGDANNNG------SSSGAPADPPAAAAAAAAPVPTSTAPASVAPSGSTSSKTSEISQEGNRWT 625
            .|..:|..|      :::....|.........|.|...|          |..||:|......:..
Human   602 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALT----------TDGKTAEDLARSEQHE 656

  Fly   626 SKTTSSSSWNRPTLKGGLFSQASSSSQSQSTYDDGKGKTKISSLSVRLQQSIEETPKLS-NGNSS 689
            ......:...:.|.: |||.|                       .:|..|:::...||. .|:|.
Human   657 HVAGLLARLRKDTHR-GLFIQ-----------------------QLRPTQNLQPRIKLKLFGHSG 697

  Fly   690 SSKSLVQSQRKSTVQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSSNYIASNASNSIS 754
            |.|:       :.|:::.....|||..::..|.|:|:|.....                     |
Human   698 SGKT-------TLVESLKCGLLRSFFRRRRPRLSSTNSSRFPP---------------------S 734

  Fly   755 TSASNPSSTGASNPITTSASNESASSRRAKFRINQMSRDVPVGLPDTH 802
            ..||.|:.:.:.|.:.....|.|..||...|........:.|.:..||
Human   735 PLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTH 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	120/264 (45%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	117/258 (45%)
DAPK1	NP_001275658.1	STKc_DAPK1	7..275	CDD:271096	120/270 (44%)
		Calmodulin-binding	267..334		13/100 (13%)
		Autoinhibitory domain. /evidence=ECO:0000250	292..301		1/38 (3%)
		ANK	373..497	CDD:238125	23/132 (17%)
		ANK repeat	378..409	CDD:293786	9/35 (26%)
		ANK 1	378..407		8/33 (24%)
		ANK 2	411..440		4/28 (14%)
		ANK repeat	412..442	CDD:293786	5/32 (16%)
		ANK	439..564	CDD:238125	20/129 (16%)
		ANK repeat	444..475	CDD:293786	5/30 (17%)
		ANK 3	444..473		5/28 (18%)
		ANK repeat	477..508	CDD:293786	5/30 (17%)
		ANK 4	477..506		4/28 (14%)
		ANK	505..629	CDD:238125	22/125 (18%)
		ANK repeat	510..541	CDD:293786	5/32 (16%)
		ANK 5	510..539		5/30 (17%)
		Ank_2	<515..768	CDD:330894	57/314 (18%)
		ANK repeat	543..574	CDD:293786	6/30 (20%)
		ANK 6	543..572		6/28 (21%)
		ANK repeat	576..607	CDD:293786	5/30 (17%)
		ANK 7	576..605		5/28 (18%)
		ANK repeat	609..638	CDD:293786	4/28 (14%)
		ANK 8	609..638		4/28 (14%)
		ANK 9	875..904
		ANK 10	1162..1196
		Death_DAPK1	1308..1393	CDD:260052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810