DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and Camk4

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	XP_006525606.1	Gene:	Camk4 / 12326	MGIID:	88258	Length:	497	Species:	Mus musculus

Alignment Length:	480	Identity:	141/480 - (29%)
Similarity:	237/480 - (49%)	Gaps:	64/480 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PAFPMRDVTINRN-------VDAHKH------YDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVP 66
            |:.|...||.:..       :|....      ::|..|:|||....||:|:.|......|.|.
Mouse    38 PSSPCSSVTASTENLVPDYWIDGSNRDPLGDFFEVESELGRGATSIVYRCKQKGTQKPYALKV-- 100

  Fly    67 IPKREDKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERV 131
            :.|..||:.|..|:.::..|.|..||:|...:|....:.:||||:.|||||||:|:..: .:||.
Mouse   101 LKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGY-YSERD 164

  Fly   132 CRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNR-IKIIDFGLARKFDPDKRLRVLFGTP 195
            ....::|:.||:|::|.|||||.||||||:|..|...:. :||.||||::..:....::.:.|||
Mouse   165 AADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTP 229

  Fly   196 EFVAPEVVNFDCISYG--TDMWSVGVICYVLISGLSPFMGENDIETM-SNVTIAKYDFEDECFNG 257
            .:.|||::. .| :||  .||||||:|.|:|:.|..||..|...:.| ..:...:|.|....::.
Mouse   230 GYCAPEILR-GC-AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDE 292

  Fly   258 ISPECLDFIAKLLAKDLSTRMTAAECMKHKWLQQRPA------TAA------TATPITKAA--SA 308
            :|....|.:.||:..|...|:|..:.::|.|:..:.|      ||.      .|....|||  :.
Mouse   293 VSLNAKDLVKKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAV 357

  Fly   309 ASKSRLKSVSPV-TAPSESSEDSTE--TIEDEDDEEEVAVQQAKQKDQQQDEELANLCGD--AEL 368
            .:.|||.|.|.. |:..|:.:.|::  :.:|..|..::..::.:::||::|:..|....|  .:|
Mouse   358 VASSRLGSASSSHTSIQENHKASSDPPSTQDAKDSTDLLGKKMQEEDQEEDQVEAEASADEMRKL 422

  Fly   369 ENKELDATKD-NLKNFIVRWETHPNSPYVFDVEGNVIAPLSETSYPHPRRTHGADSLSSSRVCSP 432
            :::|::  || .:|      |...:|....|.|..:     ||..|..:| ...:.|.|..
Mouse   423 QSEEVE--KDAGVK------EEETSSMVPQDPEDEL-----ETDDPEMKR-DSEEKLKSVE---- 469

  Fly   433 SPCDSISTLTDDERGDIE-DLPEED 456
               :.:..:|::|..|.. .:|::|
Mouse   470 ---EEMDPMTEEEAPDAGLGVPQQD 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	93/258 (36%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	91/252 (36%)
Camk4	XP_006525606.1	STKc_CaMKIV	66..359	CDD:270987	101/297 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810