DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and Mylk2

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_476557.2	Gene:	Mylk2 / 117558	RGDID:	620934	Length:	610	Species:	Rattus norvegicus

Alignment Length:	315	Identity:	143/315 - (45%)
Similarity:	209/315 - (66%)	Gaps:	17/315 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IDDSEPEGVLEPA-FPMRDVTINR-NVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVP 66
            :||..|    .|| ||.|.|.:.. ||::....:....:|.||||.|..|.:::.||:||||.:.
  Rat   271 LDDCPP----PPAPFPHRIVELRTGNVNSEFSMNSKEALGGGKFGAVCTCTERSTGLKLAAKVIK 331

  Fly    67 IPKREDKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERV 131
            ....:||..|..|:|:||.|.|..:||||:|.|....:.:.:|.|||||||:|:||:::.|||..
  Rat   332 KQTPKDKEMVLLEIEVMNQLNHRNLIQLYSAIETSHEIILFMEYIEGGELFERIVDEDYQLTEVD 396

  Fly   132 CRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPE 196
            ..||:||:|:.:.|:|...::||||||||||.:...|:.:|||||||||:::|:::|:|.|||||
  Rat   397 TMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPE 461

  Fly   197 FVAPEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPE 261
            |::|||||:|.||..|||||:|||.|:|:||||||:|::|.||::||..|.:.|::|.|..:|.|
  Rat   462 FLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDE 526

  Fly   262 CLDFIAKLLAKDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKS 316
            ..||::.|:.||.|.||:|.:|:.|.||..          :.:.|...:: ||||
  Rat   527 AKDFVSNLITKDQSARMSAEQCLAHPWLNN----------LAEKAKRCNR-RLKS 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	125/254 (49%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	125/248 (50%)
Mylk2	NP_476557.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..240
		PKc_like	295..554	CDD:419665	125/258 (48%)
		Calmodulin-binding. /evidence=ECO:0000250	588..600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13223
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000818
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2697
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910