DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and Stk33

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_473444.1	Gene:	Stk33 / 117229	MGIID:	2152419	Length:	491	Species:	Mus musculus

Alignment Length:	371	Identity:	98/371 - (26%)
Similarity:	175/371 - (47%)	Gaps:	39/371 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDK--RNVEREVEIMNSLQHHLIIQLYAAYEYQK 102
            :|:|.||.|::..||..|.:.|.|.|...|....  :.:||||.|:.::.|..||.|...:|..:
Mouse   117 LGQGSFGMVFEAIDKETGAKWAIKKVNKEKAGSSAMKLLEREVSILKTVNHQHIIHLEQVFESPQ 181

  Fly   103 MMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLT-- 165
            .|.:|:||.|.||| ..|:|.....:|...|:.|:.:..|:|::|...|||.|||.|||:|.:
Mouse   182 KMYLVMELCEDGEL-KAVMDQRGHFSENETRLIIQSLASAIAYLHNKDIVHRDLKLENIMVKSSF 245

  Fly   166 -----QKGNRIKIIDFGLARKFDPDK---RLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVICY 222
                 :....||:.||||:.:....:   .::...|||.::||||:|....|...|:||:|||.:
Mouse   246 IDDNNEMNLNIKVTDFGLSVQKHGSRSEGMMQTTCGTPIYMAPEVINAHDYSQQCDIWSIGVIMF 310

  Fly   223 VLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAECMKHK 287
            :|:.|..||:..::.:....:...:..||:..:..:|....:.:.:|:..|.:.|:||.|.:.::
Mouse   311 ILLCGEPPFLANSEEKLYELIKKGELRFENPVWESVSDSAKNTLKQLMKVDPAHRITAKELLDNQ 375

  Fly   288 WLQQRPATAATATPI----------------------TKAASAASKSRLKSVSPVTAPSESSEDS 330
            ||.....::|..|.:                      |:.::..|.|...:..|..|..:.:.:|
Mouse   376 WLTGNTLSSARPTNVLEMMKEWKNNPESDEETNTDEETEQSAVYSPSANTAKQPTNAAKKPAAES 440

  Fly   331 TETIEDEDDEEEVAVQQAKQKDQQQDEELANLCGDAELENKELDAT 376
            ...........::...::|.:.::..|.:    |.|.:....|.:|
Mouse   441 VGMTSSNSSSSKLLSAESKAEPEKSSETV----GHASVAKTTLKST 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	82/260 (32%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	82/260 (32%)
Stk33	NP_473444.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..89
		PKc_like	109..377	CDD:419665	82/260 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..491		12/89 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900