DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sqa and Mylk

DIOPT Version :9

Sequence 1:NP_001260832.1 Gene:sqa / 36002 FlyBaseID:FBgn0259678 Length:888 Species:Drosophila melanogaster
Sequence 2:NP_647461.3 Gene:Mylk / 107589 MGIID:894806 Length:1950 Species:Mus musculus


Alignment Length:510 Identity:177/510 - (34%)
Similarity:262/510 - (51%) Gaps:90/510 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 DDSEPEGVLEPAFPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPK 69
            ||.|.    ||....|.||:|........||:...:|.||||.|::..:|..|...|.||.....
Mouse  1470 DDDEK----EPEVDYRTVTVNTEQKVSDVYDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYS 1530

  Fly    70 REDKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRV 134
            .::|.|:.:|:.|||.|.|..::|...|:|.:..:.:|||::.|||||:|::|::|.||||.|..
Mouse  1531 AKEKDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIK 1595

  Fly   135 FIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVA 199
            ::||:.|.:.:||..||||||||||||:.:.:.|.|||:|||||||:.:....|:||||||||||
Mouse  1596 YMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVA 1660

  Fly   200 PEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLD 264
            |||:|::.|.|.|||||:|||||:|:||||||||:||.||::|||.|.:||:||.|:.||.:..|
Mouse  1661 PEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKD 1725

  Fly   265 FIAKLLAKDLSTRMTAAECMKHKWLQ-------------------------QRPATAATATPITK 304
            ||:.||.||:..|:...:|::|.||.                         |:...|..|  |.:
Mouse  1726 FISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRA--IGR 1788

  Fly   305 AASAASKSRLKSVSPVTAPSESSEDSTETIEDEDDEEEVAVQQAKQKDQQQDEELANLCGDAELE 369
            .:|.|..|.|......|. |.:|..:.|.:|.|||..:..::...::........:...      
Mouse  1789 LSSMAMISGLSGRKSSTG-SPTSPINAEKLESEDDVSQAFLEAVAEEKPHVKPYFSKTI------ 1846

  Fly   370 NKELDATKDNLKNFIVRWETHPNSPYV-----------------FDVEGNVIAPLSETSYPHPRR 417
             ::|:..:.:...|..:.|.:|:...|                 :|.:||.              
Mouse  1847 -RDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNC-------------- 1896

  Fly   418 THGADSLSSSRVCSPS----PCDSISTLTDD-----------ERGDIEDLPEEDE 457
                 ||..|.||...    .|.::::|.:.           |.|:.|:..||:|
Mouse  1897 -----SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEEGGEEEE 1946

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sqaNP_001260832.1 S_TKc 34..289 CDD:214567 129/254 (51%)
STKc_MLCK 40..289 CDD:271005 127/248 (51%)
MylkNP_647461.3 I-set 42..132 CDD:254352
Ig 42..131 CDD:299845
I-set 165..254 CDD:254352
Ig 183..251 CDD:143165
23ISL 255..409 CDD:293226
I-set 411..501 CDD:254352
Ig 428..498 CDD:143165
I-set 511..597 CDD:254352
IGc2 524..587 CDD:197706
I-set 620..709 CDD:254352
Ig 637..706 CDD:143165
I-set 718..806 CDD:254352
Ig 721..806 CDD:299845
I-set 1129..1218 CDD:254352
IGc2 1142..1208 CDD:197706
Ig 1269..1366 CDD:299845
I-set 1269..1358 CDD:254352
FN3 1362..1453 CDD:238020
STKc_MLCK1 1492..1750 CDD:271093 129/257 (50%)
Pkinase 1495..1750 CDD:278497 129/254 (51%)
I-set 1840..1930 CDD:254352 15/115 (13%)
IGc2 1853..1920 CDD:197706 13/85 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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