DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqa and SPEG

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	XP_011508781.1	Gene:	SPEG / 10290	HGNCID:	16901	Length:	3277	Species:	Homo sapiens

Alignment Length:	1026	Identity:	229/1026 - (22%)
Similarity:	374/1026 - (36%)	Gaps:	307/1026 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKRNVEREVEIMNSLQHHLIIQLYAAY 98
            ||:..|:|||.|..:.:..::::||:.||||:| .:.:.|.:..||..::..|||..::..:.|:
Human  1611 YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIP-SQAKPKASARREARLLARLQHDCVLYFHEAF 1674

  Fly    99 EYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLKPENILV 163
            |.::.:.:|.||.. .||.:|:.....|....: |.::|||.|.:.::|.:.::|||:||||:||
Human  1675 ERRRGLVIVTELCT-EELLERIARKPTVCESEI-RAYMRQVLEGIHYLHQSHVLHLDVKPENLLV 1737

  Fly   164 LTQKG--NRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVICYVLIS 226
            .....  .:::|.|||.|::..|.:.....:|||||||||:||...:|..||:|.|||:.::.::
Human  1738 WDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLT 1802

  Fly   227 GLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAECMKHKWLQQ 291
            |:|||:||||..|:.|:......||:..|..:|.|...|:.|:|.:| ..|.||.|.::|.|.:.
Human  1803 GISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWFKT 1866

  Fly   292 RPATAATATPITKAASAASKSRLKSVS--------PV----TAPSE-----------------SS 327
            :...|..:|...|...:..:.:...:|        |:    .||.|                 ||
Human  1867 QAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVTMPRRPPPSGGLSSS 1931

  Fly   328 EDSTETIEDEDDEEEVAVQQAKQKDQQQDEELANLCGDAELENKELDATKDNLKNFIVRWETHPN 392
            .||    |:|:.||..:|.:..|.:.........   |...|::.|...           ||...
Human  1932 SDS----EEEELEELPSVPRPLQPEFSGSRVSLT---DIPTEDEALGTP-----------ETGAA 1978

  Fly   393 SPYVFDVEGNVIAPLSETSYPHPRRTHGADSLSSSRVCSPSPCDSISTLTDDERGDIEDLPEEDE 457
            :|..:..:|.  ||..:...|.|.             ..|||....:......||::.      .
Human  1979 TPMDWQEQGR--APSQDQEAPSPE-------------ALPSPGQEPAAGASPRRGELR------R 2022

  Fly   458 SRSAENESPR--------------SVATPINES-------------------------REKLF-- 481
            ..|||:..||              ||..|...|                         |::|.
Human  2023 GSSAESALPRAGPRELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRG 2087

  Fly   482 ------------------------PTVATSSPSTPTPQH---LFNENFDEFSG-SQSTAQ---QQ 515
                                    |.:|.::.|...|.|   |.|....:.|. ||..|:   :.
Human  2088 GPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRH 2152

  Fly   516 RSMKSYLHTFDRRNSDTTYLLGRRSSGERVNLA-------------------------------- 548
            |...:.|.....|       ||.|...|..:|:
Human  2153 RRAGAPLEIPVAR-------LGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPS 2210

  Fly   549 --------------------------------DEIRKLSDHLLMLAEINTKLGDANNNGSSSGAP 581
                                            ..::.|:..|...|:|...|..:.:....|..|
Human  2211 DAPQPPAPQPAQDKAPEPRPEPVRASKPAPPPQALQTLALPLTPYAQIIQSLQLSGHAQGPSQGP 2275

  Fly   582 ADPP-------AAAAAAAAP--------VPTSTAPASVA-----------PSGSTSSKTSEISQE 620
            |.||       |..|..|:|        ||::..|..:|           |..|.||....:..|
Human  2276 AAPPSEPKPHAAVFARVASPPPGAPEKRVPSAGGPPVLAEKARVPTVPPRPGSSLSSSIENLESE 2340

  Fly   621 -----------------GNRWTSKTTS-----------SSSWNRPTLKGGLFSQASSSSQSQSTY 657
                             |.|..|::.|           .....||:..|..........:|:|..
Human  2341 AVFEAKFKRSRESPLSLGLRLLSRSRSEERGPFRGAEEEDGIYRPSPAGTPLELVRRPERSRSVQ 2405

  Fly   658 D-DGKGKT-KISSLSVRLQQSIEETP---------------KLSNGNSSSSKSLVQSQRKS---T 702
            | ...|:. .:..||:.|.|.:..||               :.|.|.||:..|.|.:.|:.   |
Human  2406 DLRAVGEPGLVRRLSLSLSQRLRRTPPAQRHPAWEARGGDGESSEGGSSARGSPVLAMRRRLSFT 2470

  Fly   703 VQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSS--------NYIASNASNSISTSASN 759
            ::.:||...||.:::.....|..|:.:.....|:::...|        |.:|:.|      .|:.
Human  2471 LERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRATSEGESLRRLGLPHNQLAAQA------GATT 2529

  Fly   760 PS--STGASNPITTSASNESASSRRAKFRINQMSRDVPVGLPDTHQTVNLE 808
            ||  |.|:....|:.:|....|..|.::..::..:|..:..|:...:|..|
Human  2530 PSAESLGSEASATSGSSAPGESRSRLRWGFSRPRKDKGLSPPNLSASVQEE 2580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	92/256 (36%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	89/250 (36%)
SPEG	XP_011508781.1	I-set	43..125	CDD:254352
		Ig	45..125	CDD:299845
		I-set	732..821	CDD:254352
		Ig	755..822	CDD:299845
		SPEG_u2	822..878	CDD:293256
		I-set	879..969	CDD:254352
		IGc2	892..959	CDD:197706
		I-set	983..1068	CDD:254352
		Ig	995..1065	CDD:143165
		I-set	1074..1163	CDD:254352
		Ig	1091..1163	CDD:299845
		I-set	1198..1287	CDD:254352
		Ig	1215..1287	CDD:299845
		I-set	1400..1490	CDD:254352
		I-set	1495..1584	CDD:254352
		Ig	1512..1581	CDD:143165
		STKc_SPEG_rpt1	1608..1864	CDD:271010	92/256 (36%)
		S_TKc	1611..1864	CDD:214567	92/256 (36%)
		I-set	2594..2684	CDD:254352
		Ig	2615..2684	CDD:299845
		STKc_SPEG_rpt2	2972..3228	CDD:271013
		S_TKc	2976..3228	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810