DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqa and mylkl

DIOPT Version :9

Sequence 1:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	XP_002935598.3	Gene:	mylkl / 100489678	XenbaseID:	XB-GENE-923293	Length:	855	Species:	Xenopus tropicalis

Alignment Length:	383	Identity:	144/383 - (37%)
Similarity:	221/383 - (57%)	Gaps:	42/383 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIYIDDSEPEGVLEPAFPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFV 65
            |:...|.|.||  |.:....:|::|.....:..|..|.::|.||||.|||.::::.|...|.||.
Frog   390 MLCAGDEETEG--EGSNGYTNVSVNTTEHFNDFYIQLEKLGMGKFGQVYKLKERSTGKICAGKFF 452

  Fly    66 PIPKREDKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTER 130
            ....:::.:....|||:||.|.|..:::..:|::....:.:|||.|.|||||:|:|.|:|..||.
Frog   453 KARTQKEIQGARVEVELMNKLHHPQLVRCLSAFQEPGRVVMVLEYIAGGELFERIVADDFEHTEV 517

  Fly   131 VCRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTP 195
            :|..:|.|:...:|::|...|||||||||||:.|....|::|||||||||:.||...::||.||.
Frog   518 MCVEYICQILNGVAYMHHQSIVHLDLKPENIICLNTVSNQVKIIDFGLARELDPHVPMKVLQGTA 582

  Fly   196 EFVAPEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISP 260
            |||||||:.|:.:.:.|||||:|||||:|:||.|||.|.||:|||.|:|.|.:||:||....:|.
Frog   583 EFVAPEVIAFEPVGFTTDMWSLGVICYILLSGDSPFQGNNDMETMQNITSACWDFDDETNALLSE 647

  Fly   261 ECLDFIAKLLAKDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKS--------- 316
            ...||:.:||.|::.:|:||.:.:.|.|:|.: ..:.|.|        .||.|:|.
Frog   648 TAKDFVKRLLQKNMRSRLTAVQALDHPWVQHK-CVSKTKT--------LSKERIKKFLARQKWQK 703

  Fly   317 ----------VSPVTAPSESSEDSTETIEDEDDEEEVAVQQAKQ-----------KDQ 353
                      ::.::|.|:::..||.| :...|.::|::...:|           |||
Frog   704 TGKAVLALNRMALLSAKSDNNTTSTHT-DGSHDCQQVSMHLQEQLQAAPVFSTLLKDQ 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	117/254 (46%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	115/248 (46%)
mylkl	XP_002935598.3	Ig	207..297	CDD:416386
		Ig strand A'	208..212	CDD:409353
		Ig strand B	216..225	CDD:409353
		Ig strand C	229..235	CDD:409353
		Ig strand C'	238..240	CDD:409353
		Ig strand D	246..251	CDD:409353
		Ig strand E	255..260	CDD:409353
		Ig strand F	268..276	CDD:409353
		Ig strand G	279..289	CDD:409353
		FN3	293..388	CDD:238020
		PKc_like	427..675	CDD:419665	115/247 (47%)
		Ig	757..841	CDD:416386	3/4 (75%)
		Ig strand A'	759..762	CDD:409353	2/2 (100%)
		Ig strand B	766..775	CDD:409353
		Ig strand C	780..786	CDD:409353
		Ig strand C'	789..791	CDD:409353
		Ig strand D	797..802	CDD:409353
		Ig strand E	805..813	CDD:409353
		Ig strand F	821..828	CDD:409353
		Ig strand G	831..841	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000818
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010