DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo18a and zip

DIOPT Version :9

Sequence 1:XP_036012684.1 Gene:Myo18a / 360013 MGIID:2667185 Length:2493 Species:Mus musculus
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:2243 Identity:564/2243 - (25%)
Similarity:1007/2243 - (44%) Gaps:482/2243 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse   389 AAEEAWYETEKVWLVHRDGFSLASQLKSEELSLPEGKARVKLDHDGAILDVDEDDIEKANAPSCD 453
            |.:..|.:...||:.|.:...:|:.:|.|.    ..:..|:|...|..:.:..|||:|.|.|..|
  Fly    71 ATQAEWTQKRLVWVPHENQGFVAASIKREH----GDEVEVELAETGKRVMILRDDIQKMNPPKFD 131

Mouse   454 RLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLSTRGAPAVYSEKVMHMFKGCRREDM 518
            ::||:|.|..|||:||||.::.||.:.|::||:|...:|::......:|:||:|..:||.:|.::
  Fly   132 KVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEV 196

Mouse   519 APHIYAVAQTAYRAMLMSRQDQSIVLLGSSGSGKTTSFQHLVQYLATIAGT-------------- 569
            .||::|:..:|||.||..|:||||:..|.||:|||.:.:.::|:||.:|.:              
  Fly   197 PPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVL 261

Mouse   570 ---------------------------SGTKVFSV-------EKWQAL---STLLEAFGNSPTIM 597
                                       :|.|:..|       |..|.|   :.:||||||:.|:.
  Fly   262 INFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVK 326

Mouse   598 NGSATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDATLRTELH 662
            |.:::||.:.:.::||.:|.::.|:|:|.||||.|..|:...|.||::||.|||......|.:..
  Fly   327 NDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFI 391

Mouse   663 LNHLAENNVFGIVPLSKPEEKQKAAQQFSKLQA---AMKVLAISPEEQKTCWLILASIYHLGAAG 724
            |     ::|.....||...........:::.||   :|.::.::.|:..:.:.|::::...|:..
  Fly   392 L-----DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMK 451

Mouse   725 ATKEPLEEQDEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQLKGGTLQRSTSFRQGPE 789
            ..:|  ...|:|.      ...:..|||.|:|||.|:.:::.|....::|.|            .
  Fly   452 FRQE--RNNDQAT------LPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVG------------R 496

Mouse   790 ESGLGEGTKLSALECLEGMASGLYSELFTLLISLVNRALKSSQHSLCSMM-IVDTPGFQNPEWGG 853
            :......||......:|.:|...|..:|..|::.:||:|..::....|.: |:|..||:..|.. 
  Fly   497 DFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN- 560

Mouse   854 SARGASFEELCHNYAQDRLQRLFHERTFLQELERYKEDNIELAFD----DLEPVADDSVAAVDQA 914
                 |||:||.||..::||:||:...|:.|.|.|:.:.||..|.    ||:|..|         
  Fly   561 -----SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTID--------- 611

Mouse   915 SHLVRSLAHADEARGLLWLLEEEALVPGATEDALLDRLFSYYG--PQ--EGDKKGQSPLLRSSKP 975
              |:      |:..|::.||:||...|.||:...:|:|.|.:.  |:  :.|.:|.:        
  Fly   612 --LI------DKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFRGVA-------- 660

Mouse   976 RHFLLGHSHGTNWVEYNVAGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIA 1040
             .|.:.|..|.  |:|:.|.|| ....:|..:|...|||.||...:.|::            ..|
  Fly   661 -DFAIVHYAGR--VDYSAAKWL-MKNMDPLNENIVSLLQGSQDPFVVNIW------------KDA 709

Mouse  1041 GLEGGSQLALRRATSMRKTFTTGMAAVKK---KSLCIQIKLQVDALIDTIKRSKMHFVHCFLPVA 1102
            .:.|.:|.||        |.|...|..:|   :::....|.|:..|:||::.:..:||.|.:|..
  Fly   710 EIVGMAQQAL--------TDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNH 766

Mouse  1103 EGWPGEPRSASSRRVSSSSELDLPPGDPCEAGLLQLDVSLLRAQLRGSRLLDAMRMYRQGYPDHM 1167
            |...|                             ::|..|:..|||.:.:|:.:|:.|||:|:.:
  Fly   767 EKRAG-----------------------------KIDAPLVLDQLRCNGVLEGIRICRQGFPNRI 802

Mouse  1168 VFSEFRRRFDVLAPHLTKKHGRNYIVVDEKRAVEELLESLDLEKSSCCLGLSRVFFRAGTLARLE 1232
            .|.|||:|:::|.|::..|.     .:|.|:|.|:::::|:|:.:...:|.|::|||||.||.||
  Fly   803 PFQEFRQRYELLTPNVIPKG-----FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLE 862

Mouse  1233 EQRDEQTSRHLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPL 1297
            |:||.:.|..:..|||.|||:|||::::||..|..|||.:|:|......:::|.||:|:|.|:||
  Fly   863 EERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPL 927

Mouse  1298 IQVQLSEEQIRNKDEEIQQLRSKLEKVEKERNELRLSSDRLETRISELTSELTDE----RNTGES 1358
            ::|...||::..|::|::|:|.||:.:.|...|......:.....:.|..:|..|    ....||
  Fly   928 LEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEES 992

Mouse  1359 ASQLLDAETAERLRTEKEMKELQTQYD-------ALKKQMEVMEMEVMEARLIRAAEINGEVDDD 1416
            .|:|:    |.:...|..|:||:|:.:       ||..:.:.:|:.:.        ::..:::::
  Fly   993 RSRLM----ARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQ--------DLEEQLEEE 1045

Mouse  1417 DAGGEWRLKYERAVREVDFTKKRLQQEL---EDKMEVEQQSRRQLERRLGDLQ---ADSDESQRA 1475
            :|..: :|:.|:.  ::|...|:.:::|   :|:.:...:.::.||.|..||.   |:.:|..:.
  Fly  1046 EAARQ-KLQLEKV--QLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKH 1107

Mouse  1476 LQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEETQREKLQREKLQREKD 1540
            |.:||.|.:...:||:: :||.:.||  ..|.::.:|:.::|::...|:....::|.:::|.:..
  Fly  1108 LAKLKAKHEATISELEE-RLHKDQQQ--RQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLA 1169

Mouse  1541 MLLAEAFSLKQQMEEKDLDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQ 1605
            ....|......:::|:....|...:....||::|.:|......::|:.||.:|..|||..:::..
  Fly  1170 KREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEAL 1234

Mouse  1606 EEEL---------DEQAGSIQMLEQAKLRLEMEMER---------MRQTHSKEMESRDEEVEEAR 1652
            :.||         .::..|.:..|.|.|:..:|.|.         ||..||:|:.|.::::|..|
  Fly  1235 KNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLR 1299

Mouse  1653 QSCQKKLKQMEVQLEEEYED-----------KQKALREKRELESKLSTLSDQVNQRDFESEKRLR 1706
            :: :..|::.:..||.|..|           :|:..|.:::.||:::.|  ||...:.|   |.|
  Fly  1300 KA-KTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAEL--QVKLAEIE---RAR 1358

Mouse  1707 KDL--KRTKALLADAQIMLDHLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEMEDLHL 1769
            .:|  |.||.                  ::|...:.|||||:|...:||||:...||.::.:...
  Fly  1359 SELQEKCTKL------------------QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQ 1405

Mouse  1770 QIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQMN------ 1828
            .:::..:.|..|..:|.:::.||..:|.:||||    :|..:.::..:|:.:..|.::.      
  Fly  1406 LLEEETRQKLGLSSKLRQIESEKEALQEQLEED----DEAKRNYERKLAEVTTQMQEIKKKAEED 1466

Mouse  1829 -DLQAQIEESNKEKQELQEKLQALQSQVEFL--EQSMVDKS---LVSRQEAKIRELETR----LE 1883
             ||..::||.   |:.|.:.::||:.||:.|  :...:|||   :.|..|....|||.:    ||
  Fly  1467 ADLAKELEEG---KKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLE 1528

Mouse  1884 FEKTQVKRLENLASRLKETMEKLTEERDQRAAAENREKE--------------------QNKRLQ 1928
            .||.| |..:.:.:..|...|::.:||| .|..|.||||                    :|||  
  Fly  1529 LEKKQ-KNFDKILAEEKAISEQIAQERD-TAEREAREKETKVLSVSRELDEAFDKIEDLENKR-- 1589

Mouse  1929 RQLRDTKEEMSELARKEAEASRKKHE-------LEMDLESLEAANQSLQADLKLA---------- 1976
               :..:.|:.:||..:..|.:..||       ||..|..|:|.|:.|:.||:|.          
  Fly  1590 ---KTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVN 1651

Mouse  1977 -------FKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKK----------KNKLEGD-SDV 2023
                   |:|  ||.|  ::|...::...|:..|:|:.|:..::          |.||||| .::
  Fly  1652 MQALRSQFER--DLLA--KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEI 1712

Mouse  2024 DS--ELEDRV--DGVKSWLSKNKGPSKAPSDDGSLKSSRTALNSLPKEGKGPEERPSSVLSSLSY 2084
            ::  |:.::|  |.:|...........|..|....|:::..|.:|.||.    ||....|     
  Fly  1713 ETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEA----ERKVKAL----- 1768

Mouse  2085 RKRLTLKDSIGGTGDQDSLLTTLSERATSPERPPRKARGGPREEPDQAQGRRCEELDDCSSIFSG 2149
                            ::.:..|:|...|.||    ||.....|.|:.    .||          
  Fly  1769 ----------------EAEVLQLTEDLASSER----ARRAAETERDEL----AEE---------- 1799

Mouse  2150 VGSRPGRGL----EKRWGSDFDRSSTVSAPVSRASSATRGSGE---DRARSS------LSFSLSG 2201
            :.:...:|.    |||      |.....|.:.......:.:.|   ||:|.:      |:..|:.
  Fly  1800 IANNANKGSLMIDEKR------RLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELAN 1858

Mouse  2202 SPSSRRRSTSRLDSLSSAISPSWNRASGLGRESPDSRLSLGQ-SCLDEWDDGASVALSEA----- 2260
            ..|:.:::.              |..:.|.|::.:.:..|.: .........|::|..||     
  Fly  1859 EKSNSQKNE--------------NGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANL 1909

Mouse  2261 HSQFSHPSLARSLSVPPQPRGSSSASASVIE-----GSSVRPVSRH-----------SYLDPDLE 2309
            ..|..:....|.|    |.:.:......:.|     ....|.|.:|           ..|..:|:
  Fly  1910 EEQLENEGKERLL----QQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLD 1970

Mouse  2310 AAINEVLSYKPVPFQRSRLEPDSEDDDRKSIQSARSAQLEHPERGSSIRRSASAADVSSR-SGRK 2373
            ....|:...|.   |:.:.:.:.||    .|:|..:...|.....:.:||:......||| :|..
  Fly  1971 ETEEELQKEKT---QKRKYQRECED----MIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTP 2028

Mouse  2374 SRSKHRSKRSSPSPSSSSSSSSSSSSSEGSSAH 2406
            |     |||:........||....|.....||:
  Fly  2029 S-----SKRAGGGGGGDDSSVQDESLDGEDSAN 2056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo18aXP_036012684.1 PDZ_signaling 220..308 CDD:238492
COG5022 429..1950 CDD:227355 448/1670 (27%)
MYSc_Myo18 467..1224 CDD:276837 220/822 (27%)
MDN1 <1782..2121 CDD:227596 101/413 (24%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/40 (23%)
Myosin_head 133..854 CDD:278492 227/834 (27%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 220/822 (27%)
Myosin_tail_1 931..2011 CDD:279860 266/1213 (22%)
Prefoldin 1431..1515 CDD:298833 24/90 (27%)
FAM76 <1847..1926 CDD:292665 15/96 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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