Protein Alignment Uba1 and NAE1

DIOPT Version :10

• Sequence 1: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001273429.1
• Gene: NAE1 / 8883
• HGNCID: 621
• Length: 537
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 119/532 - (22%)
• Similarity: 174/532 - (32%)
• Gaps: 169/532 - (31%)

  Fly   189 AAAGGDIDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGLEIAKNVILG---GVKSITLHDTA 250
            |..|..:.|..|.|||.:.|......:.::.:.|......|.||.||::|.   |:.|.|:.|..
Human     2 AQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGNVGIGSFTIIDGN 66

  Fly   251 TCGLHDLSSQFYLTEADIGKNRAEASCAQLAELNNYVRTVSHTGPLTEE-----------FLRKF 304
            .....|..:.|:|..:.||||||||:...|.|||:.|     :|...||           |..:|
Human    67 QVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDV-----SGSFVEESPENLLDNDPSFFCRF 126

  Fly   305 RVVVLTNSDGEEQQRIAKFAHENGIALIIAETRGLFA--------------------------KV 343
            .|||.|........|:|.....:.|.|:|..|.||..                          |.
Human   127 TVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKP 191

  Fly   344 FCDFGESFTIYDQDGTQ-------PISTMIA-------SITHD----------------AQGVV- 377
            |.:..|.|..||.|..:       |...:||       |.|:.                .||::
Human   192 FPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILK 256

  Fly   378 --------------------TCLDETR------HGFNDGDYVTFS-------------------E 397
                                |.|:.|:      ..|||...:..:                   |
Human   257 NENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKE 321

  Fly   398 VQGMQELNGCQPLKITVLGPY--------TFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQA 454
            .||...:.|..|..|...|.|        ..:..|.:..|.:.:..:.:..:.|::||.|.|...
Human   322 GQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLL 386

  Fly   455 TEEPEFL----------------------ISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPWN 497
            .....||                      ||.....|:...|::...|:..:.| ..|..|...|
Human   387 CSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHK-QQGRYPGVSN 450

  Fly   498 ---EED-------ANSFLEVVRASSNAEVDEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKACS 552
               |||       ...||:....|  ..|.:..|.:|.:..:.....:.|.:||..||||:|..:
Human   451 YQVEEDIGKLKSCLTGFLQEYGLS--VMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIIT 513

  Fly   553 GKF-----TPIY 559
            .:|     |.||
Human   514 KQFVIFNNTYIY 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	117/527 (22%)
NAE1	NP_001273429.1	APPBP1_RUB	11..535	CDD:238770	116/523 (22%)
		Interaction with UBA3	334..347		3/12 (25%)