Protein Alignment Uba1 and UBA4

DIOPT Version :10

• Sequence 1: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_011979.1
• Gene: UBA4 / 856511
• SGDID: S000001153
• Length: 440
• Species: Saccharomyces cerevisiae
• Alignment Length: 478
• Identity: 109/478 - (22%)
• Similarity: 180/478 - (37%)
• Gaps: 123/478 - (25%)

  Fly   499 EDANSFLEVVRASSNAEVDEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLY 563
            ||..|.||.:|. .||::.|    |.||                      :..|.:..|:
Yeast     7 EDTTSELEALRL-ENAQLRE----QLAK----------------------REDSSRDYPL----- 39

  Fly   564 FDALECLPTEGVEEADAQPVGSRYDSQIAI---FGKKFQEKLADSKWFIVGAGAIGCELLKNFGM 625
                      .:||.      .||..|:.:   .|...|.||.::|..:||||.:||..|....
Yeast    40 ----------SLEEY------QRYGRQMIVEETGGVAGQVKLKNTKVLVVGAGGLGCPALPYLA- 87

  Fly   626 LGLGTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAE 690
               |.|.|||.:.|.|::|.|||:||.|.....|...|..:|...|.::||.:||..|.:|:.:.
Yeast    88 ---GAGVGQIGIVDNDVVETSNLHRQVLHDSSRVGMLKCESARQYITKLNPHINVVTYPVRLNSS 149

  Fly   691 TEKVFSEDFFGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQV-----IVPFAT 750
            .    :.|.|...:.:.:..|:...|..:....:...|.:|....|||.|.:.:     |.|...
Yeast   150 N----AFDIFKGYNYILDCTDSPLTRYLVSDVAVNLGITVVSASGLGTEGQLTILNFNNIGPCYR 210

  Fly   751 ESYSSSQDPPEKSIPICT----------LKNFPNAIEHTLQWARDAFEGVFKQSAENAAQ----Y 801
            ..|.:  .||..::..|.          |.....|:| ||:    ...|::  :.||.:.    |
Yeast   211 CFYPT--PPPPNAVTSCQEGGVIGPCIGLVGTMMAVE-TLK----LILGIY--TNENFSPFLMLY 266

  Fly   802 IADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFA-HCVEWARLYWEDQYVNQIKQLLF--- 862
            ...||.:.|..|:.|.|        :|.|...|.::.. ..:|...:.:|          ||
Yeast   267 SGFPQQSLRTFKMRGRQ--------EKCLCCGKNRTITKEAIEKGEINYE----------LFCGA 313

  Fly   863 -NF----PPDQIT-SSGQPFWSGPKRCPDPLVFDVNDPMHLDFIY--AAANLRAEVYGIEQVRNR 919
             |:    |.::|: .:.|..:...:.....:..||....|.:..:  .|.|:     .|:.:|:.
Yeast   314 RNYNVCEPDERISVDAFQRIYKDDEFLAKHIFLDVRPSHHYEISHFPEAVNI-----PIKNLRDM 373

  Fly   920 ETIAELVQKVKVPEFKPRSGVKI 942
            ....:.:|: |:|..:..|.:.|
Yeast   374 NGDLKKLQE-KLPSVEKDSNIVI 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	109/478 (23%)
UBA4	NP_011979.1	ThiF_MoeB_HesA_family	46..279	CDD:238386	67/249 (27%)
		RHOD_ThiF	316..440	CDD:238784	15/86 (17%)