DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and UBA1

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_012712.1	Gene:	UBA1 / 853670	SGDID:	S000001693	Length:	1024	Species:	Saccharomyces cerevisiae

Alignment Length:	1034	Identity:	514/1034 - (49%)
Similarity:	702/1034 - (67%)	Gaps:	43/1034 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 SSNMAGNSAAAGGDIDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSIT 245
            |||.:|.|||  |:||||||||||||||.:||.:|..|::|:.||.|||:||||||:|.||||:|
Yeast     2 SSNNSGLSAA--GEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGVEIAKNVVLAGVKSMT 64

  Fly   246 LHDTATCGLHDLSSQFYLTEADIGKNRAEASCAQLAELNNY--VRTVSHTGPLTEEFLRKFRVVV 308
            :.|.....|.|||:||:|||.|||:.|.:.:.|:|||||.|  |..:.....:|:  |.:|:|||
Yeast    65 VFDPEPVQLADLSTQFFLTEKDIGQKRGDVTRAKLAELNAYVPVNVLDSLDDVTQ--LSQFQVVV 127

  Fly   309 LTNSDG-EEQQRIAKFAHENGIALIIAETRGLFAKVFCDFGESFTIYDQDGTQPISTMIASITHD 372
            .|::.. |::.:|.:|.|.:||..|.:||||||...|.|.|:.||:.|..|.:|.:.|::.|..|
Yeast   128 ATDTVSLEDKVKINEFCHSSGIRFISSETRGLFGNTFVDLGDEFTVLDPTGEEPRTGMVSDIEPD 192

  Fly   373 AQGVVTCLDETRHGFNDGDYVTFSEVQGMQELNGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVA 437
              |.||.||:.|||..||::|.||||:|:.:||.....|:.||||:.|.||...::||||.||:.
Yeast   193 --GTVTMLDDNRHGLEDGNFVRFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEYKKGGIF 255

  Fly   438 TQVKMPKTISFKPLAQATEEPEFLISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPWNEEDAN 502
            |:||:|:.||||.|.|....|||:.|||||.|..|.||:.|.||..:...|||.|||..|:||||
Yeast   256 TEVKVPRKISFKSLKQQLSNPEFVFSDFAKFDRAAQLHLGFQALHQFAVRHNGELPRTMNDEDAN 320

  Fly   503 SFLEVVRASS---------NAEVDEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPI 558
            ..:::|...|         ..:|:|.|:.:.:....|:...:.|..||:|||||||||||||||:
Yeast   321 ELIKLVTDLSVQQPEVLGEGVDVNEDLIKELSYQARGDIPGVVAFFGGLVAQEVLKACSGKFTPL 385

  Fly   559 YQWLYFDALECLPTE---GVEEADAQPVGSRYDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELL 620
            .|::|||:||.||..   ...|...|||.||||:|||:||..||:|:|:||.|:||:||||||:|
Yeast   386 KQFMYFDSLESLPDPKNFPRNEKTTQPVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEML 450

  Fly   621 KNFGMLGLGTG-NGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEV--NVTA 682
            ||:.:||||:| :|.|.|||.|.||||||||||||||.||.|.||..||:|:..|||::  .:.|
Yeast   451 KNWALLGLGSGSDGYIVVTDNDSIEKSNLNRQFLFRPKDVGKNKSEVAAEAVCAMNPDLKGKINA 515

  Fly   683 YELRVGAETEKVFSEDFFGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVP 747
            ...:||.|||::|::.|:..||.|.|||||||||.|:||:|:|.|.||:|:|||||.||.|||:|
Yeast   516 KIDKVGPETEEIFNDSFWESLDFVTNALDNVDARTYVDRRCVFYRKPLLESGTLGTKGNTQVIIP 580

  Fly   748 FATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQSAENAAQYIADPQFTERIA 812
            ..|||||||:||||||||:|||::|||.|:||:.||:..|:|.|..||||...|:..|.|.|:..
Yeast   581 RLTESYSSSRDPPEKSIPLCTLRSFPNKIDHTIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTL 645

  Fly   813 KLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARLYWEDQYVNQIKQLLFNFPPDQITSSGQPFW 877
            |..| ....:|:||..:| ..||.:|..|::||||.:|.::.:.|||||||||.|..||:|:|||
Yeast   646 KQSG-DVKGVLESISDSL-SSKPHNFEDCIKWARLEFEKKFNHDIKQLLFNFPKDAKTSNGEPFW 708

  Fly   878 SGPKRCPDPLVFDVNDPMHLDFIYAAANLRAEVYGIE-----QVRNRETIAELVQKVKVPEFKPR 937
            ||.||.|.||.||:.:..|..|:.|.|:|||..|||:     ...|.:....::..:.:|||.|.
Yeast   709 SGAKRAPTPLEFDIYNNDHFHFVVAGASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMIIPEFTPN 773

  Fly   938 SGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKNADKSS----KITPLEFEKDDDSNLHM 998
            :.:||:.|:.....:||..:    ..|.:|:::|.|   .|.|:    |:.|::||||||:|.|:
Yeast   774 ANLKIQVNDDDPDPNANAAN----GSDEIDQLVSSL---PDPSTLAGFKLEPVDFEKDDDTNHHI 831

  Fly   999 DFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVLSGLAVLEVIKLIVGHRDLVKFKN 1063
            :||.||||.||.||.|..|||.|:|.|||:||||||||||:::||..||:.|||....|:.::||
Yeast   832 EFITACSNCRAQNYFIETADRQKTKFIAGRIIPAIATTTSLVTGLVNLELYKLIDNKTDIEQYKN 896

  Fly  1064 GFANLALPFMAFSEPLPAAKNTYYGKEW-TLWDRFEVTGELSLQEFLNYFEENEKLKITMLSQGV 1127
            ||.||||||..||||:.:.|..|..|:: .:||||::.|::.|.:.:.:||::|.|:|||||.||
Yeast   897 GFVNLALPFFGFSEPIASPKGEYNNKKYDKIWDRFDIKGDIKLSDLIEHFEKDEGLEITMLSYGV 961

  Fly  1128 SMLYSFFMPKAKCSERLPLPMSEVVRRVSKRRLEPHERSLVFEICCNDVDGEDVEVPYV 1186
            |:||:.|.|..|..|||.||::::|:.|:|:.:..|..:::.|||.:|.:|||||||::
Yeast   962 SLLYASFFPPKKLKERLNLPITQLVKLVTKKDIPAHVSTMILEICADDKEGEDVEVPFI 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	506/1021 (50%)
		Ube1_repeat1	199..574	CDD:238768	185/389 (48%)
		E1_4HB	447..510	CDD:292809	32/62 (52%)
		Ube1_repeat2	606..1144	CDD:238767	280/550 (51%)
UBA1	NP_012712.1	Ube1	13..1023	CDD:273603	506/1021 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343988
Domainoid	1	1.000	500	1.000	Domainoid score	I49
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22002
Inparanoid	1	1.050	951	1.000	Inparanoid score	I35
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54221
OrthoFinder	1	1.000	-	-		FOG0001106
OrthoInspector	1	1.000	-	-		oto99142
orthoMCL	1	0.900	-	-		OOG6_100444
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1577
SonicParanoid	1	1.000	-	-		X1782
TreeFam	1	0.960	-	-
	15	14.790