Protein Alignment Uba1 and Nae1

DIOPT Version :10

• Sequence 1: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_114461.3
• Gene: Nae1 / 84019
• RGDID: 619945
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 533
• Identity: 118/533 - (22%)
• Similarity: 179/533 - (33%)
• Gaps: 174/533 - (32%)

  Fly   189 AAAGGDIDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCG 253
            |..|..:.|..|.|||.:.|......:.::.:.|......|.||.||::|.|:.|.|:.|.....
  Rat     2 AQQGKILKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVS 66

  Fly   254 LHDLSSQFYLTEADIGKNRAEASCAQLAELNNYVRTVSHTGPLTEE-----------FLRKFRVV 307
            ..|:.:.|:|.:..||||||:|:...|.|||:.|     :|...||           |..:|.:|
  Rat    67 GEDVGNNFFLQKCSIGKNRAQAAMEFLQELNSDV-----SGSFVEESPENLLDNDPSFFCRFTIV 126

  Fly   308 VLTNSDGEEQQRIAKFAHENGIALIIAETRGLFA--------------------------KVFCD 346
            |.|........|:|.....:.|.|:|..|.||..                          |.|.:
  Rat   127 VATQLLESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPE 191

  Fly   347 FGESFTIYDQDGTQ-------PISTMIA-------SITHD----------------AQGVV---- 377
            ..|.|..||.|..:       |...:||       |.|:.                .||::
  Rat   192 LREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKSYKEKEDFRELIRQGILKNEN 256

  Fly   378 -----------------TCLDETR------HGFNDGDYVTFSE--------VQGMQEL-----NG 406
                             |.|:.|:      ..|||...:..::        .:.::|.     .|
  Rat   257 GAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQG 321

  Fly   407 CQPLKITVLGPYTFSIGDTSKF----------GEYKSGGVATQV--------KMPKTISFKPLAQ 453
            ..|::    |.....|.|:||:          .:..:..|...|        :.|::||.|.|..
  Rat   322 NLPVR----GTIPDMIADSSKYIKLQNVYREKAKKDAAAVGNHVAKLLQSVGQAPESISEKELKL 382

  Fly   454 ATEEPEFL----------------------ISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPW 496
            ......||                      ||.....|:...|::...|:..:.|.| |..|...
  Rat   383 LCSNSAFLRVVRCRSLAEEYGLHTVNKDEIISSMDNPDNEIVLYLMLRAVDRFHKQH-GRYPGVS 446

  Fly   497 N---EED-------ANSFLEVVRASSNAEVDEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKAC 551
            |   |||       ...||:....|  ..|.:..|.:|.:..:.....:.|.:||..||||:|..
  Rat   447 NYQVEEDIGKLKSCLTGFLQEYGLS--VMVKDDYVHEFCRYGAAEPHTVAAFLGGAAAQEVIKII 509

  Fly   552 SGKF-----TPIY 559
            :.:|     |.||
  Rat   510 TKQFVIFNNTYIY 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	116/528 (22%)
Nae1	NP_114461.3	APPBP1_RUB	11..532	CDD:238770	115/524 (22%)
		Interaction with UBA3. /evidence=ECO:0000250	331..344		4/12 (33%)