DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and UBA1

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_565693.1	Gene:	UBA1 / 817562	AraportID:	AT2G30110	Length:	1080	Species:	Arabidopsis thaliana

Alignment Length:	1082	Identity:	469/1082 - (43%)
Similarity:	676/1082 - (62%)	Gaps:	35/1082 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 KRPEKRNYLNTTTIESQEASSSASATSNSNNNVSSSNNNSNNSTNNRQLEGSS-----NMA-GNS 188
            ||..:.|..|..||...:.:||.....:...:.|..:::...|.::|...|.|     :|| |||
plant     4 KRASEANDKNDNTIIGSDLASSKKRRIDFTESSSDKSSSILASGSSRGFHGDSVVQQIDMAFGNS 68

  Fly   189 AAAGGDIDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCG 253
            ...  :|||.|:||||.|.|.:.|||:..|::|:||:.|||.|||||:||.||||:||||.....
plant    69 NRQ--EIDEDLHSRQLAVYGRETMRRLFASNVLISGMHGLGAEIAKNLILAGVKSVTLHDERVVE 131

  Fly   254 LHDLSSQFYLTEADIGKNRAEASCAQLAELNNYVRTVSHTGPLTEEFLRKFRVVVLTNSDGEEQQ 318
            |.||||.|..:|.|:|||||:||..:|.:|||.|...|.|..|.:|.|..|:|||.::.   ..:
plant   132 LWDLSSNFVFSEDDVGKNRADASVQKLQDLNNAVVVSSLTKSLNKEDLSGFQVVVFSDI---SME 193

  Fly   319 RIAKF-----AHENGIALIIAETRGLFAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVT 378
            |..:|     :|:..||.:.|:.||||..||||||..|.:.|.||.:|.:.:||||:::.|..::
plant   194 RAIEFDDYCHSHQPPIAFVKADVRGLFGSVFCDFGPEFAVLDVDGEEPHTGIIASISNENQAFIS 258

  Fly   379 CLDETRHGFNDGDYVTFSEVQGMQELNGCQPLKITVLGPYTFSIG-DTSKFGEYKSGGVATQVKM 442
            |:|:.|..|.|||.|.||||:||.|||..:|.||....||:|::. ||:.:|.|..||:.||||.
plant   259 CVDDERLEFEDGDLVVFSEVEGMTELNDGKPRKIKSTRPYSFTLDEDTTNYGTYVKGGIVTQVKQ 323

  Fly   443 PKTISFKPLAQATEEP-EFLISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFLE 506
            ||.::||||.:|.::| :||.|||:|.|.|..||:||.||..: ||..|..|...:||||...:.
plant   324 PKLLNFKPLREALKDPGDFLFSDFSKFDRPPLLHLAFQALDHF-KAEAGRFPVAGSEEDAQKLIS 387

  Fly   507 VVRASSNAE-------VDEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYF 564
            :..|.:..:       ||:||:..|:........|:.|..||||.|||:|||||||.|::|:.||
plant   388 IATAINTGQGDLKVENVDQKLLRHFSFGAKAVLNPMAAMFGGIVGQEVVKACSGKFHPLFQFFYF 452

  Fly   565 DALECLPTEGVEEADAQPVGSRYDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLG 629
            |::|.||:|.|:.:|..|..||||:||::||.|||:||.|:|.|.||:||:|||.|||..::|:.
plant   453 DSVESLPSEPVDSSDFAPRNSRYDAQISVFGAKFQKKLEDAKVFTVGSGALGCEFLKNLALMGVS 517

  Fly   630 TGN-GQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEK 693
            .|: |::.|||.|:||||||:||||||..::.:.||..||.|...:||..|:.|.:.|||||||.
plant   518 CGSQGKLTVTDDDIIEKSNLSRQFLFRDWNIGQAKSTVAASAAAVINPRFNIEALQNRVGAETEN 582

  Fly   694 VFSEDFFGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQD 758
            ||.:.|:..|..|.||||||:||:|:|.:|::.:.||:|:|||||..|.|.::|..||:|.:|:|
plant   583 VFDDAFWENLTVVVNALDNVNARLYVDSRCLYFQKPLLESGTLGTKCNTQSVIPHLTENYGASRD 647

  Fly   759 PPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQSAENAAQYIADP-QFTERIAKLPGIQPLEI 822
            ||||..|:||:.:||:.|:|.|.|||..|||:.:::......|::.| ::|..:......|..:.
plant   648 PPEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPAEVNAYLSSPVEYTNSMMSAGDAQARDT 712

  Fly   823 LDSIKKALIDDKPKSFAHCVEWARLYWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPL 887
            |:.|.:.|..:|.::|..|:.||||.:||.:||::|||::.||.|..||:|.||||.|||.|.||
plant   713 LERIVECLEKEKCETFQDCLTWARLRFEDYFVNRVKQLIYTFPEDAATSTGAPFWSAPKRFPRPL 777

  Fly   888 VFDVNDPMHLDFIYAAANLRAEVYGI---EQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAA 949
            .:..:||..|:||.|.|.||||.:||   |..:|.:..||.|.:|.||:|:||...||.|:|.|.
plant   778 QYSSSDPSLLNFITATAILRAETFGIPIPEWTKNPKEAAEAVDRVIVPDFEPRQDAKIVTDEKAT 842

  Fly   950 AASANNFDDGELDQDRVDKIISELLKNADKSSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKI 1014
            ..:..:.||..:..|.:.| |.:...|.....::.|::||||||:|.|||.|...:|:||.||.|
plant   843 TLTTASVDDAAVIDDLIAK-IDQCRHNLSPDFRMKPIQFEKDDDTNYHMDVIAGLANMRARNYSI 906

  Fly  1015 PPADRHKSKLIAGKIIPAIATTTSVLSGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPL 1079
            |..|:.|:|.|||:|||||||:|::.:||..||:.|::.|...:..::|.|||||||..:.:|||
plant   907 PEVDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVLDGGHKVEAYRNTFANLALPLFSMAEPL 971

  Fly  1080 PAAKNTYYGKEWTLWDRFEVTGELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERL 1144
            |.....:....||:|||:.:.|..:|:|.|.:.|: :.|....:|.|..:|::....:.|  ||:
plant   972 PPKVVKHRDMAWTVWDRWVLKGNPTLREVLQWLED-KGLSAYSISCGSCLLFNSMFTRHK--ERM 1033

  Fly  1145 PLPMSEVVRRVSKRRLEPHERSLVFEICCNDVDGEDVEVPYV 1186
            ...:.::.|.|:|..|.|:...|...:.|.|.|..||::|.|
plant  1034 DKKVVDLARDVAKVELPPYRNHLDVVVACEDEDDNDVDIPLV 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	451/1012 (45%)
		Ube1_repeat1	199..574	CDD:238768	180/388 (46%)
		E1_4HB	447..510	CDD:292809	28/63 (44%)
		Ube1_repeat2	606..1144	CDD:238767	236/542 (44%)
UBA1	NP_565693.1	Ube1	72..1078	CDD:273603	451/1012 (45%)
		Ube1_repeat1	77..462	CDD:238768	180/388 (46%)
		E1_4HB	328..393	CDD:292809	29/65 (45%)
		Ube1_repeat2	494..1033	CDD:238767	236/542 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	459	1.000	Domainoid score	I93
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	854	1.000	Inparanoid score	I65
OMA	1	1.010	-	-		QHG54221
OrthoDB	1	1.010	-	-		D91748at2759
OrthoFinder	1	1.000	-	-		FOG0001106
OrthoInspector	1	1.000	-	-		otm3170
orthoMCL	1	0.900	-	-		OOG6_100444
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1782
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840