DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and UBA5

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_079094.1	Gene:	UBA5 / 79876	HGNCID:	23230	Length:	404	Species:	Homo sapiens

Alignment Length:	430	Identity:	90/430 - (20%)
Similarity:	170/430 - (39%)	Gaps:	141/430 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 VEEADAQPVGSR-YDSQIAIFGKKF-----QEKLADSKWFIVGAGAIG---CELLKNFGMLGLGT 630
            :|:..::.|.|. |...:|:  |:.     .||:......|||.|.:|   .|:|...|:
Human    40 IEKMSSEVVDSNPYSRLMAL--KRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGI----- 97

  Fly   631 GNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEV-------NVTAYEL--- 685
              |::.:.|.|.:|.:|:||.| |:||.....|...|...::.:||:|       |:|..|.
Human    98 --GKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFQH 159

  Fly   686 ---RV---GAETEKVFSEDFFGKLDGVANALDNVDARIYMDRKCIFNRI--PLVETGTL--GTLG 740
               |:   |.|..|        .:|.|.:.:||.:||:.::..|  |.:  ..:|:|..  ...|
Human   160 FMDRISNGGLEEGK--------PVDLVLSCVDNFEARMTINTAC--NELGQTWMESGVSENAVSG 214

  Fly   741 NVQVIVPFATESYSSSQDPP--------EKSIP---ICTLKNFPNA--------IEHTLQWARDA 786
            ::|:|:|..:..::.:  ||        ||::.   :|. .:.|..        :::.|::..:
Human   215 HIQLIIPGESACFACA--PPLVVAANIDEKTLKREGVCA-ASLPTTMGVVAGILVQNVLKFLLN- 275

  Fly   787 FEGVFKQSAENAAQYI-------ADPQ------------FTERIAKLPGIQPLEILDSIKKALID 832
            |..|......||.|..       .:||            :.:::|.||   ..|::...::.:.:
Human   276 FGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQEEYKKKVAALP---KQEVIQEEEEIIHE 337

  Fly   833 DKPKSFAHCVEWARLYWEDQYVNQI-KQLLFNFP------PDQITSSGQPFWSGPKRCPDPLVFD 890
            |..             |..:.|::: ::.|.||.      |:.||.:    ::.||:..|
Human   338 DNE-------------WGIELVSEVSEEELKNFSGPVPDLPEGITVA----YTIPKKQED----- 380

  Fly   891 VNDPMHLDFIYAAANLRAEVYGIEQVRNRETIAELVQKVK 930
                       :...|..|..|       |::.:|:.|:|
Human   381 -----------SVTELTVEDSG-------ESLEDLMAKMK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	90/430 (21%)
		Ube1_repeat1	199..574	CDD:238768
		E1_4HB	447..510	CDD:292809
		Ube1_repeat2	606..1144	CDD:238767	82/393 (21%)
UBA5	NP_079094.1	ThiF_MoeB_HesA_family	52..297	CDD:238386	62/268 (23%)
UBA5	NP_079094.1	UFM1-interacting sequence (UIS). /evidence=ECO:0000269\|PubMed:26929408, ECO:0000269\|PubMed:27653677	334..346		2/24 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810