DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba1 and uba5

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001004790.1	Gene:	uba5 / 448010	XenbaseID:	XB-GENE-955661	Length:	399	Species:	Xenopus tropicalis

Alignment Length:	429	Identity:	94/429 - (21%)
Similarity:	157/429 - (36%)	Gaps:	134/429 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 TEGVEEADAQPVGSRYDSQIAIFGKKF-----QEKLADSKWFIVGAGAIG---CELLKNFGMLGL 628
            |...|..|:.|    |...:|:  |:.     .||:......:||.|.:|   .|:|...|:
Frog    38 TMSAEVVDSNP----YSRLMAL--KRMGIVEDYEKIRTFTVAVVGVGGVGSVTAEMLTRCGI--- 93

  Fly   629 GTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEK 693
                |::.:.|.|.:|.:|:||.| |:||.....|...|...::.:||:|....:...:......
Frog    94 ----GKLLLFDYDKVEMANMNRLF-FQPHQAGLSKVEAAEHTLRNINPDVQFEVHNYNITTLDNF 153

  Fly   694 VFSEDFFGK--------LDGVANALDNVDARIYMDRKCIFNRIPLV--ETGTL--GTLGNVQVIV 746
            ....|...|        :|.|.:.:||.:||:.::..|  |.:..:  |:|..  ...|::|:|.
Frog   154 QHFMDRISKGGLKEGTPVDLVLSCVDNFEARMAINTAC--NELVQIWMESGVSENAVSGHIQLIK 216

  Fly   747 PFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQSAENAAQYIADPQFTERI 811
            |..|..::.:  ||        |....|..|.||:     .|||.                   .
Frog   217 PGETACFACA--PP--------LVVAANIDEKTLK-----REGVC-------------------A 247

  Fly   812 AKLP---GIQPLEILDSIKKALIDDKPKSFAHCVEWARLYWEDQYV--NQIKQLLFNFPPDQITS 871
            |.||   |:....::.::.|.|::....||              |:  |.::..   ||...:..
Frog   248 ASLPTTMGVVAGMLVQNVLKYLLNFGTVSF--------------YLGYNAMQDF---FPTMAMKP 295

  Fly   872 SGQPFWSGPKRC----------------PDPLVFDVNDPMHLDFIYAAANLRAEVYGIE---QVR 917
            :.|   .|.|.|                .:|:|....:.:|.|          ..:|||   :|.
Frog   296 NPQ---CGDKYCRKQQEEFKLKEAARPKQEPIVVKEEEIVHED----------NDWGIELVSEVS 347

  Fly   918 NRE------TIAELVQKVK----VPEFKPRSGVKIETNE 946
            ..|      .:.||.:.:|    ||..:|.||..:|.:|
Frog   348 EEELKAASGPVPELPEGIKVAYTVPITEPTSGFIVEDSE 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	94/429 (22%)
		Ube1_repeat1	199..574	CDD:238768	1/1 (100%)
		E1_4HB	447..510	CDD:292809
		Ube1_repeat2	606..1144	CDD:238767	85/390 (22%)
uba5	NP_001004790.1	ThiF_MoeB_HesA_family	48..293	CDD:238386	68/311 (22%)
uba5	NP_001004790.1	UFM1-interacting sequence (UIS). /evidence=ECO:0000250\|UniProtKB:Q9GZZ9	331..343		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910