Protein Alignment Uba1 and uba1

DIOPT Version :10

• Sequence 1: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_998227.1
• Gene: uba1 / 406335
• ZFINID: ZDB-GENE-040426-2009
• Length: 1058
• Species: Danio rerio
• Alignment Length: 1063
• Identity: 636/1063 - (59%)
• Similarity: 796/1063 - (74%)
• Gaps: 31/1063 - (2%)

  Fly   152 ASATSNSNNNVSSSNNNSN---NSTNNRQLEGSSNMAGNSAAAGGD--IDESLYSRQLYVLGHDA 211
            :|:..:....||.|...:.   :|:|:.:.|.|...|...|..|.|  |||.|||||||||||||
Zfish     2 SSSPLSKKRRVSGSETKTGSHCSSSNSVRTELSHTPANGMAKNGNDAEIDEGLYSRQLYVLGHDA 66

  Fly   212 MRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADIGKNRAEAS 276
            |:||.:|::|:|||.|||:|||||||||||||:||||.......||||||||.|.|:|||||:.|
Zfish    67 MKRMQSSNVLISGLRGLGVEIAKNVILGGVKSVTLHDQGVAEWKDLSSQFYLREEDLGKNRADVS 131

  Fly   277 CAQLAELNNYVRTVSHTGPLTEEFLRKFRVVVLTNSDGEEQQRIAKFAHENGIALIIAETRGLFA 341
            ..:|||||:||...|:||.||.|:|.||:|||||||..:||.||.:|.|.|||.||:|:|||||.
Zfish   132 QPRLAELNSYVPVTSYTGTLTNEYLTKFQVVVLTNSSLDEQTRIGEFCHSNGIKLIVADTRGLFG 196

  Fly   342 KVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTCLDETRHGFNDGDYVTFSEVQGMQELNG 406
            ::||||||...::|.:|.||:|.||:.||.|:.||||||||.||||..||||||:|||||.||||
Zfish   197 QLFCDFGEVMIVFDTNGEQPLSAMISMITKDSAGVVTCLDEARHGFESGDYVTFTEVQGMTELNG 261

  Fly   407 CQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQATEEPEFLISDFAKLDSP 471
            |.|::|..||||||||.|||.|.:|..||:.|||||||.|:||.|:.:..|||||::||||.|.|
Zfish   262 CDPVEIKTLGPYTFSICDTSSFSDYVRGGIVTQVKMPKKIAFKSLSSSMAEPEFLLTDFAKFDRP 326

  Fly   472 ATLHVAFNALSCYRKAHNGALPRPWNEEDANSFL---EVVRASSNA-----EVDEKLVLQFAKIC 528
            ..|||.|.||..:.|.|: .||:|||:.||:..:   |.|.|:...     |:|:.::.:.|.:.
Zfish   327 GQLHVGFQALHAFEKKHS-RLPKPWNQADADELMTLAEEVNAAQTGSAKQEELDQAVIKKLACVA 390

  Fly   529 SGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYFDALECLPTEG---VEEADAQPVGSRYDSQ 590
            :|:..|::|.:||:.||||:|||:|||.||.||||||||||||...   :.|.:..|...|||.|
Zfish   391 AGDLAPVNAFIGGLAAQEVMKACTGKFMPIMQWLYFDALECLPEPEEVILTEEECAPRNCRYDGQ 455

  Fly   591 IAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTGNGQIFVTDMDLIEKSNLNRQFLFR 655
            ||:||.|.||.||..::|:||||||||||||||.|:||.:|.|::.|||||.|||||||||||||
Zfish   456 IAVFGSKLQELLAKQRYFLVGAGAIGCELLKNFAMMGLASGEGEVIVTDMDTIEKSNLNRQFLFR 520

  Fly   656 PHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDARIYMD 720
            |.||.|.||.|||.|:|:|||.|.:|.::.|||.:||||:.:|||..||||||||||||||:|||
Zfish   521 PWDVTKMKSETAAAAVKQMNPSVRITGHQNRVGPDTEKVYDDDFFECLDGVANALDNVDARMYMD 585

  Fly   721 RKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARD 785
            |:|::.|.||:|:|||||.|||||::||.||||||||||||||||||||||||||||||||||||
Zfish   586 RRCVYYRKPLLESGTLGTKGNVQVVIPFITESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARD 650

  Fly   786 AFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARLYWE 850
            .|||:|||.||||.||:.|.:|.||..||||.||||:::|:.|:|:.|:|:::..||.|||.:|:
Zfish   651 EFEGLFKQPAENALQYLTDSKFMERTLKLPGAQPLEVVESVYKSLVTDRPRNWDDCVTWARNHWQ 715

  Fly   851 DQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAANLRAEVYGIEQ 915
            .||.|.|:|||.||||||:||||.||||||||||.||.|..|:.:|:|:|.|||||.|..||:..
Zfish   716 CQYNNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLEFSTNNDLHMDYILAAANLYALSYGLPS 780

  Fly   916 VRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKNADKS 980
            ..:|..:.:|:|.:|||||.|:|||||..::....::..:.||..|::      :..||.:.:.|
Zfish   781 CNDRSALTKLLQDIKVPEFTPKSGVKIHVSDQELQSANASVDDSRLEE------LKTLLPSLEAS 839

  Fly   981 S--KITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVLSGL 1043
            |  |:.|:|||||||:|.|||||||.|||||.||.||||||||||||||||||||||||:.:.||
Zfish   840 SQFKLCPIEFEKDDDTNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTAAVVGL 904

  Fly  1044 AVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAAKNTYYGKEWTLWDRFEVTG------E 1102
            ..||::|::.||:.|..:||||.||||||.|||||:.|.|:.||..:|||||||:|.|      |
Zfish   905 VCLELLKIVQGHKKLESYKNGFMNLALPFFAFSEPIAAPKHKYYEIDWTLWDRFKVKGIQPNGEE 969

  Fly  1103 LSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERLPLPMSEVVRRVSKRRLEPHERSL 1167
            ::|::||:||:...||:|||||||||||||||||.||..|||.|||:|:|.:|||::|..|.::|
Zfish   970 MTLRQFLDYFKNEHKLEITMLSQGVSMLYSFFMPAAKLKERLELPMTEIVTKVSKKKLGKHVKAL 1034

  Fly  1168 VFEICCNDVDGEDVEVPYVRYTL 1190
            |||:||||...|||||||||||:
Zfish  1035 VFELCCNDDTEEDVEVPYVRYTI 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	622/1014 (61%)
uba1	NP_998227.1	Ube1	49..1055	CDD:273603	621/1012 (61%)