DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba1 and Uba5

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_572722.2	Gene:	Uba5 / 32094	FlyBaseID:	FBgn0030305	Length:	404	Species:	Drosophila melanogaster

Alignment Length:	439	Identity:	95/439 - (21%)
Similarity:	163/439 - (37%)	Gaps:	127/439 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 LPTEGVEEADAQPVGSRYDSQIAIFGK----KFQEKLADSKWFIVGAGAIG---CELLKNFGMLG 627
            |..:.::...|:.|.|...|::....:    |..|::......|||.|.:|   .::|...|:
  Fly    35 LARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGGVGSVTADMLTRCGI-- 97

  Fly   628 LGTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETE 692
                 |::.:.|.|.:|.:|:||.| |.|......|...||..:..:||:|.:..:...:    .
  Fly    98 -----GKLILFDYDKVELANMNRLF-FTPDQAGLSKVAAAAATLSFINPDVEIETHNYNI----T 152

  Fly   693 KVFSEDFF-------GKLDG-----VANALDNVDARIYMDRKCIFNRIPLVETGTL--GTLGNVQ 743
            .|.:.|.|       |::.|     |.:.:||.:||:.::..|....:...|:|..  ...|::|
  Fly   153 TVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNERNLNWFESGVSENAVSGHIQ 217

  Fly   744 VIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQS------------AE 796
            .|.|..|..::.:  ||        |....|..|.||:     .|||...|            .:
  Fly   218 FIRPGDTACFACA--PP--------LVVAENIDEKTLK-----REGVCAASLPTTMGITAGFLVQ 267

  Fly   797 NAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPK-SFAHCVEWARLYWEDQYVNQIKQL 860
            ||.:|:.:  |.| ::...|...|.  |...|..:...|: ...:|:              ::|
  Fly   268 NALKYLLN--FGE-VSDYLGYNALS--DFFPKMTLKPNPQCDDRNCL--------------VRQ- 312

  Fly   861 LFNFPPDQITSSGQPFWSGPKRCPDPLVFD----VNDPMHLDFIYAAANLRAEVYGIEQV----- 916
                         :.|.:.||    |::.:    ..:|:|      |.|    .:|||.|
  Fly   313 -------------KEFQARPK----PVLIEEKAVSEEPLH------ATN----EWGIELVAEDAP 350

  Fly   917 RNRETIAE-------LVQKVKVPEFKPRSGVKIETNEAAAAASANNFDD 958
            .:..|.||       |....:.||   :|....|...:||.|...:.:|
  Fly   351 ESNTTPAETPVMGEGLRLAYEAPE---KSSETSEETVSAATADETSLED 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	95/439 (22%)
		Ube1_repeat1	199..574	CDD:238768	1/3 (33%)
		E1_4HB	447..510	CDD:292809
		Ube1_repeat2	606..1144	CDD:238767	88/399 (22%)
Uba5	NP_572722.2	ThiF_MoeB_HesA_family	52..297	CDD:238386	64/276 (23%)
Uba5	NP_572722.2	ThiF	53..310	CDD:279270	66/302 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446840
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840