DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and Uba1

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001014102.1	Gene:	Uba1 / 314432	RGDID:	1359327	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	1045	Identity:	623/1045 - (59%)
Similarity:	778/1045 - (74%)	Gaps:	31/1045 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 SNNSTNNRQLEGSSNMAGNSAAAGG---DIDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGL 230
            ||.|:....|...|::..|..|..|   ||||||||||||||||:||:.:..|.:|:|||.|||:
  Rat    21 SNCSSAQSVLSEVSSVPTNGMAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGV 85

  Fly   231 EIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADIGKNRAEASCAQLAELNNYVRTVSHTGP 295
            |||||:||||||::||||..|....||||||||.|.||||||||.|..:|||||:||...::|||
  Rat    86 EIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGP 150

  Fly   296 LTEEFLRKFRVVVLTNSDGEEQQRIAKFAHENGIALIIAETRGLFAKVFCDFGESFTIYDQDGTQ 360
            |.|:||..|:|||||||..|||.|:.:|.|..||.|::|:|||||.::||||||...:.|.:|.|
  Rat   151 LVEDFLSGFQVVVLTNSPLEEQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQ 215

  Fly   361 PISTMIASITHDAQGVVTCLDETRHGFNDGDYVTFSEVQGMQELNGCQPLKITVLGPYTFSIGDT 425
            |:|.|::.:|.|..||||||||.||||..||:|:|||||||.:||||||::|.|||||||||.||
  Rat   216 PLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMVQLNGCQPIEIKVLGPYTFSICDT 280

  Fly   426 SKFGEYKSGGVATQVKMPKTISFKPLAQATEEPEFLISDFAKLDSPATLHVAFNALSCYRKAHNG 490
            |.|.:|..||:.:|||:||.||||.|..:..||:|:::||||...||.||:.|.||..:...||.
  Rat   281 SNFSDYIRGGIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQALHQFCAQHNR 345

  Fly   491 ALPRPWNEEDANSFLEVVRASSNA---------EVDEKLVLQFAKICSGNTCPLDAAVGGIVAQE 546
            . |||.|||||...:.:.:| .||         .|||.|:.:.|.:.:|:..|::|.:||:.|||
  Rat   346 P-PRPRNEEDATELVTLAQA-VNARSPPAVQQDNVDEDLIRKLAYVAAGDLAPINAFIGGLAAQE 408

  Fly   547 VLKACSGKFTPIYQWLYFDALECLP--TEGVEEADAQPVGSRYDSQIAIFGKKFQEKLADSKWFI 609
            |:|||||||.||.||||||||||||  .|.:.|....|..:|||.|:|:||...||||...|:|:
  Rat   409 VMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQNRYDGQVAVFGSDLQEKLGKQKYFL 473

  Fly   610 VGAGAIGCELLKNFGMLGLGTG-NGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKR 673
            ||||||||||||||.|:|||.| .|::.|||||.||||||||||||||.||.|.||.|||.|:::
  Rat   474 VGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQ 538

  Fly   674 MNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGT 738
            |||.:.||:::.|||.:||:::.:|||..||||||||||||||:||||:|::.|.||:|:|||||
  Rat   539 MNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGT 603

  Fly   739 LGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQSAENAAQYIA 803
            .|||||::||.||||||||||||||||||||||||||||||||||||.|||:|||.|||..||:.
  Rat   604 KGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLT 668

  Fly   804 DPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARLYWEDQYVNQIKQLLFNFPPDQ 868
            |.:|.||..:|.|.||||:|::::::|:..:|:::..||.||..:|..||.|.|:|||.||||||
  Rat   669 DSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQ 733

  Fly   869 ITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAANLRAEVYGIEQVRNRETIAELVQKVKVPE 933
            :||||.||||||||||.||.||||:.:|||::.|||||.|:.||:...::|..:|.|:|.|:|||
  Rat   734 LTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPE 798

  Fly   934 FKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKNADK--SSKITPLEFEKDDDSNL 996
            |.|:|||||..::....::..:.||..|::      :...|.:.||  ..|:.|::||||||||.
  Rat   799 FTPKSGVKIHVSDQELQSANASVDDSRLEE------LKATLPSPDKLPGFKMYPIDFEKDDDSNF 857

  Fly   997 HMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVLSGLAVLEVIKLIVGHRDLVKF 1061
            |||||||.|||||.||.|.||||||||||||||||||||||:.:.||..||:.|::.||:.|..:
  Rat   858 HMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSY 922

  Fly  1062 KNGFANLALPFMAFSEPLPAAKNTYYGKEWTLWDRFEVTG------ELSLQEFLNYFEENEKLKI 1120
            ||||.||||||..|||||.|.::.||.:||||||||||.|      |::|::||:||:...||:|
  Rat   923 KNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEI 987

  Fly  1121 TMLSQGVSMLYSFFMPKAKCSERLPLPMSEVVRRVSKRRLEPHERSLVFEICCNDVDGEDVEVPY 1185
            ||||||||||||||||.||..|||..||:|:|.|||||:|..|.|:||.|:||||..||||||||
  Rat   988 TMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPY 1052

  Fly  1186 VRYTL 1190
            ||||:
  Rat  1053 VRYTI 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	612/1013 (60%)
		Ube1_repeat1	199..574	CDD:238768	223/385 (58%)
		E1_4HB	447..510	CDD:292809	28/62 (45%)
		Ube1_repeat2	606..1144	CDD:238767	340/546 (62%)
Uba1	NP_001014102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		8/27 (30%)
		Ube1	49..1055	CDD:273603	612/1014 (60%)
		2 approximate repeats. /evidence=ECO:0000255	63..611		332/559 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	640	1.000	Domainoid score	I158
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22002
Inparanoid	1	1.050	1245	1.000	Inparanoid score	I165
OMA	1	1.010	-	-		QHG54221
OrthoDB	1	1.010	-	-		D139631at33208
OrthoFinder	1	1.000	-	-		FOG0001106
OrthoInspector	1	1.000	-	-		otm44707
orthoMCL	1	0.900	-	-		OOG6_100444
Panther	1	1.100	-	-	O	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1782
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840