Protein Alignment Uba1 and Uba2

DIOPT Version :9

• Sequence 1: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001094049.1
• Gene: Uba2 / 308508
• RGDID: 1312023
• Length: 639
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 170/639 - (26%)
• Similarity: 279/639 - (43%)
• Gaps: 149/639 - (23%)

  Fly   596 KKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQ 660
            ::..|.::..:..:||||.||||||||..:    ||...|.:.|:|.|:.|||||||||:...|.
  Rat     9 RELAEAVSGGRVLVVGAGGIGCELLKNLVL----TGFSHIDLIDLDTIDVSNLNRQFLFQKKHVG 69

  Fly   661 KPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSED----FFGKLDGVANALDNVDARIYMDR 721
            :.|:..|.:::.:.:|:.|:.|:.       :.:.:.|    ||.:...|.|||||..||.:::|
  Rat    70 RSKAQVAKESVLQFHPQANIEAHH-------DSIMNPDYNVEFFRQFILVMNALDNRAARNHVNR 127

  Fly   722 KCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDA 786
            .|:...:||:|:||.|.||.|..|....||.|.....|.:::.|.||::|.|:...|.:.||:..
  Rat   128 MCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYL 192

  Fly   787 FEGVFKQSAENAAQYI----ADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARL 847
            |..:|.:  |:|.|.:    |||:        ...:|.| .::..:|..:|.........|||:.
  Rat   193 FNQLFGE--EDADQEVSPDRADPE--------AAWEPTE-AEARARASNEDGDIKRISTKEWAKS 246

  Fly   848 YWEDQ-------YVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAAN 905
            ...|.       :.:.|:.||          :....|.  ||.|         |:.||:
  Rat   247 TGYDPVKLFTKLFKDDIRYLL----------TMDKLWR--KRKP---------PVPLDW------ 284

  Fly   906 LRAEVYGIEQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKII 970
              |||    |.:..|..|:       .:.:|:.|:|               |...||......:.
  Rat   285 --AEV----QSQGEEANAD-------QQSEPQLGLK---------------DQQVLDVKSYASLF 321

  Fly   971 SELLKN-----ADKSSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKII 1030
            |:.::.     |:|... ..|.::|||..  .|||:.:.:|||...:.:....|...|.:||.||
  Rat   322 SKSIETLRVRLAEKGDG-AELIWDKDDPP--AMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNII 383

  Fly  1031 PAIATTTSVLSGLAVLEVIKLIVGHRD------LVKFKNGFANLALP----------FMAFSEPL 1079
            ||||||.:|::||.|||.:|::.|..|      |.|..|....|.:|          ::..|:|
  Rat   384 PAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNTNCYVCASKP- 447

  Fly  1080 PAAKNTYYGKEWTLWDRFEVTGELSLQE--FLNYFEENEKLKITMLSQGV-------SMLYSFFM 1135
                              |||..|::.:  .|...::..|.|..|::..|       ::|.|  .
  Rat   448 ------------------EVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILIS--S 492

  Fly  1136 PKAKCSERLPLPMSEV-VRRVSKRRLEP--HERSLVFEICCNDVDGEDVEVPYV 1186
            .:.:.....|..:|:. :|..|:.:.:.  .:.:|:..|..::..|:|||...|
  Rat   493 EEGETEANNPKKLSDFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVV 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	170/639 (27%)
		Ube1_repeat1	199..574	CDD:238768
		E1_4HB	447..510	CDD:292809
		Ube1_repeat2	606..1144	CDD:238767	158/582 (27%)
Uba2	NP_001094049.1	ThiF	9..>175	CDD:279270	63/176 (36%)
		Uba2_SUMO	19..443	CDD:238766	145/503 (29%)
		UAE_UbL	451..537	CDD:291402	14/87 (16%)
		UBA2_C	548..634	CDD:292812

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810