DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and Uba6

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001100683.1	Gene:	Uba6 / 305268	RGDID:	1308324	Length:	1053	Species:	Rattus norvegicus

Alignment Length:	1079	Identity:	451/1079 - (41%)
Similarity:	650/1079 - (60%)	Gaps:	76/1079 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 IESQEASSSASATSNSNNNVSSSNNNSNNSTNNRQLEGSSNMAGNSAAAGGDIDESLYSRQLYVL 207
            :..:|||.|:.....::.|:.:....|        ||               ||:.|||||.|||
  Rat    10 LSCEEASCSSWGACGASKNLPTMTTES--------LE---------------IDDGLYSRQRYVL 51

  Fly   208 GHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADI--GK 270
            |..||::||.|.:.|||:||||:|||||::|.|:|::|:|||..|...||.:.|:|.|.|:  .:
  Rat    52 GDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQAWDLGTNFFLCEDDVVNER 116

  Fly   271 NRAEASCAQLAELNNYVRTVSHTGPLTE----EFLRKFRVVVLTNSDGEEQQRIAKFAHEN--GI 329
            |||||...::||||.||:..|.:.|..|    .||.|::.||||.:....|::|..|.|.:  .|
  Rat   117 NRAEAVLHRVAELNPYVQVSSSSAPFDETTDLSFLEKYQCVVLTETKLTLQKKINNFCHSHCPPI 181

  Fly   330 ALIIAETRGLFAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTCLDETRHGFNDGDYVT 394
            ..|..:..|:::::|||||:.|.:.|..|.:|....|::||....|:||||:...|....|.::|
  Rat   182 KFISTDVHGIWSRLFCDFGDEFEVSDTTGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLT 246

  Fly   395 FSEVQGMQELNGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQATEEPE 459
            |.|:.||..||| ...:|||:.|::||||||::...|..||:|.|||.||..:|:||....:.|:
  Rat   247 FREINGMAGLNG-SVQQITVISPFSFSIGDTTELDPYLHGGIAVQVKTPKIFNFEPLESQIKHPK 310

  Fly   460 FLISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFLEVVRASSNA-----EVDEK 519
            .||:||:|.::|..:|||..||..:::.:: ..|....::|::..|::....|..     ||:..
  Rat   311 CLIADFSKPEAPLQIHVAMLALDQFQENYS-RKPNIRCQQDSDELLKLTICISETLEEKPEVNAD 374

  Fly   520 LVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYF---DALECLPTEGVEEADAQ 581
            :|...:....|...||.|||||:.:||||||.:|||:|:.||||.   |.:|.|...|.||  ..
  Rat   375 IVHWLSWTAQGFLPPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADTVESLGNLGHEE--FL 437

  Fly   582 PVGSRYDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTG--NGQIFVTDMDLIE 644
            |.|.|||:..|..|....:||.:...|:||.||||||:||||.:||:|||  .|.:.|||.||||
  Rat   438 PRGDRYDAFRACIGNTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTGREKGMVTVTDPDLIE 502

  Fly   645 KSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANA 709
            |||||||||||||.:|||||.|||:|..::||::.:.|:..:|...||..:|::|:.|.|.|..|
  Rat   503 KSNLNRQFLFRPHHIQKPKSYTAAEATLKINPQLKIDAHLNKVCPATESTYSDEFYNKQDIVITA 567

  Fly   710 LDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPN 774
            ||||:||.|:|.:|:.|..||:::||:||.|:.::|||..||||:|.:||||:.||.||||:||.
  Rat   568 LDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEIIVPQLTESYNSHRDPPEEEIPFCTLKSFPA 632

  Fly   775 AIEHTLQWARDAFEGVF--KQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKS 837
            |:|||:|||||.||..|  |.|..|.. :.|.|...:.:.|:...|.||....:.| |:..:|:.
  Rat   633 AVEHTIQWARDKFESSFSHKPSLFNKF-WQAYPSAEDVLQKIQNGQSLEGCFQVIK-LLSRRPRM 695

  Fly   838 FAHCVEWARLYWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYA 902
            ::.|||.|||.:|..:.::..|||..||.|.....|..||..|||.|.|:.||:|:|:||.|:..
  Rat   696 WSQCVELARLKFEKYFNHKALQLLHCFPLDTRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQN 760

  Fly   903 AANLRAEVYGI---EQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFD----DGE 960
            ||.|.|.||.|   |:..:.:::.:::.:||:.||||.:.| ::|:|     :|...|    ..|
  Rat   761 AAKLYATVYCIPFSEKDLSVDSLMDILSEVKIQEFKPSNKV-VQTDE-----TARKPDHVPVSSE 819

  Fly   961 LDQDRVDKIISELLKN-ADKSS-KITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSK 1023
            .:::.|.::...|..| |.||. ::..|.||||||||.|:|||.|.|||||..|.|.||||.|:|
  Rat   820 DERNAVFQLEKALSSNKATKSDLQMAVLSFEKDDDSNGHIDFITAASNLRAKMYNIEPADRFKTK 884

  Fly  1024 LIAGKIIPAIATTTSVLSGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAAKNTY-Y 1087
            .|||||||||||:|:.:|||..||:|| :.|......:||.|.|||:|.:.|:|.....|... .
  Rat   885 RIAGKIIPAIATSTAAVSGLVALEMIK-VAGGYPFDAYKNCFLNLAIPIIVFTETSEVRKTEIRN 948

  Fly  1088 GKEWTLWDRFEVTG--ELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERLPLPMSE 1150
            |..:|:|||:.|.|  :.:|.:|:|..:|...::.||:.|||.|||...||..  ::||.|.|.:
  Rat   949 GISFTIWDRWTVHGKEDFTLSDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGH--AKRLKLTMHK 1011

  Fly  1151 VVRRVSKRRLEPHERSLVFEICCNDVDG-EDVEVPYVRY 1188
            :|:..::::..  :.::.|   ..|.|| ||:..|.|||
  Rat  1012 LVKPSTEKKYV--DLTVSF---APDADGDEDLPGPPVRY 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	441/1026 (43%)
		Ube1_repeat1	199..574	CDD:238768	161/390 (41%)
		E1_4HB	447..510	CDD:292809	18/62 (29%)
		Ube1_repeat2	606..1144	CDD:238767	253/553 (46%)
Uba6	NP_001100683.1	Ube1	38..1046	CDD:273603	444/1043 (43%)
		Ube1_repeat1	43..428	CDD:238768	160/386 (41%)
		E1_4HB	298..358	CDD:292809	18/60 (30%)
		Ube1_repeat2	462..1005	CDD:238767	253/553 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54221
OrthoDB	1	1.010	-	-		D139631at33208
OrthoFinder	1	1.000	-	-		FOG0001106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100444
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730